Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Dean W. Felsher"'
Autor:
Beatrice Dankworth, Ming Jiang, Michael Howell, Dean W. Felsher, Arvin M. Gouw, Becky Saunders, Barrie Peck, Julian Downward, Mathias T. Rosenfeldt, Werner Schmitz, Heike Miess, Almut Schulze
Publikováno v:
Oncogene. 37:5435-5450
Metabolic reprogramming is a prominent feature of clear cell renal cell carcinoma (ccRCC). Here we investigated metabolic dependencies in a panel of ccRCC cell lines using nutrient depletion, functional RNAi screening and inhibitor treatment. We foun
Autor:
Richard N. Zare, Delaney K. Sullivan, Ling Tong, Livia S. Eberlin, Dean W. Felsher, Arvin M. Gouw, Georgia G. Toal, Katherine Margulis
Publikováno v:
Proceedings of the National Academy of Sciences. 114:4300-4305
KRAS gene mutation causes lung adenocarcinoma. KRAS activation has been associated with altered glucose and glutamine metabolism. Here, we show that KRAS activates lipogenesis, and this activation results in distinct proteomic and lipid signatures. B
Autor:
Delaney K. Sullivan, Anthony A. Mancuso, Georgia G. Toal, Annie L. Hsieh, Brian J. Altman, Arvin M. Gouw, Dean W. Felsher, Adriane Mosley, Natalie S. Liu, Sudha Janaki Raman, Katherine Margulis, Chi V. Dang, Almut Schulze, Ling Tong, Zachary E. Stine, Richard N. Zare
Publikováno v:
Cell Metab
Summary Lipid metabolism is frequently perturbed in cancers, but the underlying mechanism is unclear. We present comprehensive evidence that oncogene MYC, in collaboration with transcription factor sterol-regulated element-binding protein (SREBP1), r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd548a92d32738f13cc9c5329d137517
https://europepmc.org/articles/PMC6911354/
https://europepmc.org/articles/PMC6911354/
Autor:
Zhimin Lu, David H. Hawke, Goutham Narla, Xiaoping Ding, Patrea Rhea, Jibin Ding, Richard T. Lee, Peiying Yang, Yong Pan, Yan Jiang, Dean W. Felsher
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Mistletoe (Viscum album) is a type of parasitic plant reported to have anticancer activity including in hepatocellular carcinoma (HCC). However, the mechanism of mistletoe’s anticancer activity, and its effectiveness in treating HCC are not fully u
Autor:
Nicholas B. Struntz, Amedeo Vetere, Mattheus H.E. Wildschut, Maricela A. Ramirez, Scott E. Malstrom, Francisco Caballero, Helen L. Evans, Robert M. Wilson, Kristen R. Frombach, Hanna Tseng, Sandrine Muller, Andrew Chen, Timothy A. Lewis, Anja Deutzmann, Sarah Elmiligy, Dean W. Felsher, Tong Liang, Charles Y. Lin, Angela N. Koehler, Brice Harrison Curtin, Clementine Feau, Jiyoung A. Hong, Vincent L. Butty, Eric Stefan, Stuart S. Levine, David B. Freeman, Paul A. Clemons, Benjamin L. Ebert, Dylan V. Neel, Marius S. Pop, Marie McConkey
Publikováno v:
Andrew Chen
The transcription factor Max is a basic-helix-loop-helix leucine zipper (bHLHLZ) protein that forms homodimers or interacts with other bHLHLZ proteins, including Myc and Mxd proteins. Among this dynamic network of interactions, the Myc/Max heterodime
Autor:
Katriana Nugent, James E. Verdone, Hailun Wang, Phuoc T. Tran, Mustafa A. Barbhuiya, Takumi Shiraishi, Bin Zhang, Russell Williams, Barry D. Nelkin, Natasha E. Zachara, Roger Henry, Kekoa Taparra, Reem Malek, Kenneth J. Pienta, Audrey Lafargue, Ken Kang Hsin Wang, John Wong, Matthew Ballew, Jennifer Groves, Gokben Yildirir, Dean W. Felsher, Brian W. Simons, Xing Wang
Publikováno v:
The Journal of clinical investigation. 128(11)
Mutant KRAS drives glycolytic flux in lung cancer, potentially impacting aberrant protein glycosylation. Recent evidence suggests aberrant KRAS drives flux of glucose into the hexosamine biosynthetic pathway (HBP). HBP is required for various glycosy
Autor:
Lars Zender, Tamar Kapanadze, Michael P. Manns, Chi Ma, Carmen Ka-Man Chan, Fei Zhao, Firouzeh Korangy, Stephen M. Hewitt, Veena Kapoor, Tim F. Greten, Jaba Gamrekelashvili, Dean W. Felsher
Publikováno v:
Journal of Hepatology. 59:1007-1013
Background & Aims Myeloid derived suppressor cells (MDSC) are immature myeloid cells with immunosuppressive activity. They accumulate in tumor-bearing mice and humans with different types of cancer, including hepatocellular carcinoma (HCC). The aim o
Autor:
Alan Bilsland, Amedeo Amedei, Hiromasa Fujii, Sophie Chen, Gunjan Guha, Katia Aquilano, Neetu Singh, Kanya Honoki, Sid P. Kerkar, Xujuan Yang, William G. Helferich, Petr Heneberg, Dorota Halicka, H.P. Vasantha Rupasinghe, Wamidh H. Talib, Vasundara Venkateswaran, Stephanie C. Casey, Elena Niccolai, Maria Rosa Ciriolo, Somaira Nowsheen, Richard L. Whelan, W. Nicol Keith, Sarah Crawford, Dipita Bhakta, Fabian Benencia, Asfar S. Azmi, Sulma I. Mohammed, Alexandros G. Georgakilas, Abbas Samadi, Chandra S. Boosani, Dean W. Felsher
Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve dynamically through indirect and direct cellular interactions, eliciting multisc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b8077e15b1062f706b901cca7c6db2
https://eprints.gla.ac.uk/114305/1/114305.pdf
https://eprints.gla.ac.uk/114305/1/114305.pdf
Autor:
Patrick Whang, Beverly S. Mitchell, Daniel A. Pollyea, Min Huang, Jayanth V. Chodaparambil, Brenda Kusler, Dean W. Felsher, Liwen Xu
Publikováno v:
Journal of Biological Chemistry. 286:11035-11046
Nucleostemin (NS) is a nucleolar-nucleoplasmic shuttle protein that regulates cell proliferation, binds p53 and Mdm2, and is highly expressed in tumor cells. We have identified NS as a target of oxidative regulation in transformed hematopoietic cells
Autor:
Phuoc T. Tran, G. Yildirir, Brian W. Simons, Katriana Nugent, J. Groves, Natasha E. Zachara, Dean W. Felsher, Hao Wang, Kekoa Taparra, Reem Malek
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 96:S54-S55