Zobrazeno 1 - 10
of 23
pro vyhledávání: '"David L. Huso"'
Autor:
Liangfeng Han, Helen Sadik, Yolanda M.N. Foster, Duojia Pan, Angela Brodie, Zhe Zhang, Syed Z. Ali, Peter Ordentlich, David L. Huso, Christina Adams, Roisin M. Connolly, Soonweng Cho, Vered Stearns, Nguyen Nguyen, Preethi Korangath, Kideok Jin, Saraswati Sukumar, Xian C. Zhou, Qian Chen, Vanessa F. Merino
Publikováno v:
Cancer Research. 76:2013-2024
Efforts to induce the differentiation of cancer stem cells through treatment with all-trans retinoic acid (ATRA) have yielded limited success, partially due to the epigenetic silencing of the retinoic acid receptor (RAR)-β. The histone deacetylase i
Autor:
Herbert H. Hill, Linda Resar, David L. Huso, Lingling Xian, Leslie Cope, Michael Williams, Raymond Reeves, David R. Gang, Tait Huso, Jeong-Jin Park, William F. Siems
Publikováno v:
Journal of proteome research. 15(12)
Because colorectal cancer (CRC) remains a leading cause of cancer mortality worldwide, more accessible screening tests are urgently needed to identify early stage lesions. We hypothesized that highly sensitive, metabolic profile analysis of stool sam
Autor:
Ming Zhao, David L. Huso, Zhe Zhang, Anirban Maitra, Yong Soon Chun, Takahiro Yoshida, Dipankar Pramanik, Vered Stearns, Michelle A. Rudek, Saraswati Sukumar, Venugopal Chenna, Seung-Mo Hong, Savita Bisht, Roeland F. de Wilde
Publikováno v:
Carcinogenesis. 33:2242-2249
Multiple lines of evidence support a role for curcumin in cancer chemoprevention. Nonetheless, despite its reported efficacy and safety profile, clinical translation of curcumin has been hampered by low oral bioavailability, requiring infeasible ‘m
Autor:
David L. Huso, George Sgouros, Stephen J. Meltzer, Rachana Agarwal, Ronnie C. Mease, Gilbert Green, Yulan Cheng, Srinivasan Senthamizhchelvan, Martin G. Pomper, John M. Abraham
Publikováno v:
Cell Cycle. 11:1878-1882
The search for new therapeutic agents that are effective against cancer has been difficult and expensive. The activity of anticancer candidate agents against human cancer-derived cell lines in immunocompromised mice is an important tool in this searc
A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome
Autor:
Hamid Ehsan, Mark J. Caulfield, Oliver Squires, Nick Huso, Djahida Bedja, Nicole K Wilson, Jefferson J. Doyle, Jennifer P Habashi, Florian Schoenhoff, Mark E. Lindsay, David L. Huso, Benjamin Rusholme, Craig J. Thomas, Suha Bachir, Daniel P. Judge, Alexander J Doyle, Loretha Myers, Ryan Whitworth, Harry C. Dietz, Jennifer E. Van Eyk
Publikováno v:
eLife
eLife, Vol 4 (2015)
Elife, 4
Doyle, Jefferson J; Doyle, Alexander J; Wilson, Nicole K; Habashi, Jennifer P; Bedja, Djahida; Whitworth, Ryan E; Lindsay, Mark E; Schönhoff, Florian; Myers, Loretha; Huso, Nick; Bachir, Suha; Squires, Oliver; Rusholme, Benjamin; Ehsan, Hamid; Huso, David; Thomas, Craig J; Caulfield, Mark J; Van Eyk, Jennifer E; Judge, Daniel P and Dietz, Harry C (2015). A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome. eLife, 4 eLife Sciences Publications 10.7554/eLife.08648
eLife, Vol 4 (2015)
Elife, 4
Doyle, Jefferson J; Doyle, Alexander J; Wilson, Nicole K; Habashi, Jennifer P; Bedja, Djahida; Whitworth, Ryan E; Lindsay, Mark E; Schönhoff, Florian; Myers, Loretha; Huso, Nick; Bachir, Suha; Squires, Oliver; Rusholme, Benjamin; Ehsan, Hamid; Huso, David; Thomas, Craig J; Caulfield, Mark J; Van Eyk, Jennifer E; Judge, Daniel P and Dietz, Harry C (2015). A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome. eLife, 4 eLife Sciences Publications 10.7554/eLife.08648
Calcium channel blockers (CCBs) are prescribed to patients with Marfan syndrome for prophylaxis against aortic aneurysm progression, despite limited evidence for their efficacy and safety in the disorder. Unexpectedly, Marfan mice treated with CCBs s
Autor:
Amy Hacker-Prietz, Robert A. Casero, David L. Huso, Shervin Rabizadeh, Patrick M. Woster, Cynthia L. Sears, Andrew C. Goodwin, Xin Qun Wu, Christina E. DeStefano Shields, Shaoguang Wu, Tracy Murray-Stewart
Publikováno v:
Proceedings of the National Academy of Sciences. 108:15354-15359
It is estimated that the etiology of 20–30% of epithelial cancers is directly associated with inflammation, although the direct molecular events linking inflammation and carcinogenesis are poorly defined. In the context of gastrointestinal disease,
Autor:
David L. Huso, Clare Bao, Baktiar O. Karim, Ralph H. Hruban, Munekazu Yamakuchi, Joshua T. Mendell, Charles J. Lowenstein, Craig Lotterman
Publikováno v:
Proceedings of the National Academy of Sciences. 107:6334-6339
The pathway involving the tumor suppressor gene TP53 can regulate tumor angiogenesis by unclear mechanisms. Here we show that p53 regulates hypoxic signaling through the transcriptional regulation of microRNA-107 (miR-107). We found that miR-107 is a
Autor:
Hongni Fan, Cynthia L. Sears, Christine M. Dejea, Shaoguang Wu, Benjamin B. Finard, Abby L. Geis, Xinqun Wu, Christina E. DeStefano Shields, David L. Huso, Elizabeth C. Wick, Kai Fu, June L. Chan, Ada J. Tam, Sara W. Van Meerbeke, Liam Chung, Fengyi Wan, Florencia McAllister, Erik Thiele Orberg, Payam Fathi, Andriana Lebid, Franck Housseau, Drew M. Pardoll, Jie Chen, Paul Metz, Sudipto Ganguly
Publikováno v:
Cell host & microbe, vol 23, iss 2
Summary Pro-carcinogenic bacteria have the potential to initiate and/or promote colon cancer, in part via immune mechanisms that are incompletely understood. Using Apc Min mice colonized with the human pathobiont enterotoxigenic Bacteroides fragilis
Autor:
Rebeca Mejias, Saskia Biskup, Lichuan Yang, Ted M. Dawson, Rebecca Banerjee, Guosheng Liu, Masayuki Sasaki, M. Flint Beal, Eva Andres-Mateos, Xiaojie Li, Brian M. Lin, Bobby Thomas, David L. Huso, Valina L. Dawson, Li Zhang
Publikováno v:
The Journal of Neuroscience. 29:15846-15850
Mutations in theleucine-rich repeat kinase 2(LRRK2) gene are the most common known cause of Parkinson's disease (PD). Whether loss of LRRK2 function accounts for neurodegeneration of dopamine neurons in PD is not known, nor is it known whether LRRK2
Autor:
Jian Zhi Hu, Richard P. Phipps, Qibin Zhang, Mark K. Murphy, Donald N. Rommereim, John F. Dicello, David L. Huso
Publikováno v:
Radiation Research. 172:607-616
Herein we demonstrate that high-resolution magic angle spinning (MAS) 1H NMR can be used to profile the pathology of bone marrow rapidly and with minimal sample preparation. The spectral resolution obtained allows several metabolites to be analyzed q