Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Anna Mae Diehl"'
Gut-microbiome-inflammation interactions have been linked to neurodegeneration in Alzheimer’s disease (AD) and other disorders. We hypothesized that treatment with rifaximin, a minimally absorbed gut-specific antibiotic, may modify the neurodegener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d58ad9f91d26fec40bbc761a4d35564a
https://doi.org/10.1101/2021.11.22.21266123
https://doi.org/10.1101/2021.11.22.21266123
Autor:
Jun Zhang, Roger J. Davis, Meng Li, Christopher Q. Chen, Anna Mae Diehl, Mariam Aghajan, Ying Wang, Robert Win Maw Min, Tin Aung Than, Sanda Win, Neil Kaplowitz, Yibu Chen, Manal F. Abdelmalek, Filbert W.M. Aung, Ayako Suzuki
Publikováno v:
Journal of Clinical Investigation. 129:5278-5293
SH3 domain–binding protein that preferentially associates with Btk (SAB) is an outer-membrane docking protein for JNK-mediated impairment of mitochondrial function. Deletion of Sab in hepatocytes inhibits sustained JNK activation and cell death. Th
Autor:
Valentin Gogonea, George D. Dalton, Amanda L. Brown, Anna Mae Diehl, Seh-Hoon Oh, Stephanie Zhang, Preeti Pathak, Camelia Baleanu-Gogonea, Linda Tang, Venkateshwari Varadharajan, J. Mark Brown
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103089-(2021)
Summary: Cellular cholesterol is regulated by at least two transcriptional mechanisms involving sterol-regulatory-element-binding proteins (SREBPs) and liver X receptors (LXRs). Although SREBP and LXR pathways are the predominant mechanisms that sens
Autor:
Rajesh Kumar Dutta, Seh-Hoon Oh, Wen-Hsuan Yang, Jen-Tsan Ashley Chi, Kuo Du, Anna Mae Diehl, Tianai Sun
Publikováno v:
Liver Int
Background & aims The outcome of liver injury is dictated by factors that control the accumulation of myofibroblastic (activated) hepatic stellate cells (MF-HSCs) but therapies that specifically block this process have not been discovered. We evaluat
Autor:
Andrea G. Nackley, Wolfgang Liedtke, Anna Mae Diehl, Huiping Ding, Andreas E. Kremer, Johannes Morstein, Ana E. López-Romero, Qian Zeng, Zilong Wang, Ru-Rong Ji, Qiaojuan Zhang, Yong Chen, Xin Zhang, Piotr Milkiewicz, Tony E. Reeves, Sara L. Morales-Lázaro, Jennifer Y. Zhang, Marcin Krawczyk, Tamara Rosenbaum, Mei-Chuan Ko, Frank Lammert, Andrey V. Bortsov, Manal F. Abdelmalek, Michele Yeo, Huanghe Yang, Carlene Moore, Ying-Ai Jin
Publikováno v:
Gastroenterology. 161(1)
Background & Aims Limited understanding of pruritus mechanisms in cholestatic liver diseases hinders development of antipruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus. Meth
Autor:
Ying Wang, Cynthia D. Guy, Cynthia A. Moylan, Anna Mae Diehl, Catherine F. Howe, Manal F. Abdelmalek, Ricardo Henao, Kara Wegermann
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 5, Iss 4, Pp 608-617 (2021)
Hepatology Communications, Vol 5, Iss 4, Pp 608-617 (2021)
Identifying patients at higher risk for poor outcomes from nonalcoholic fatty liver disease (NAFLD) remains challenging. Metabolomics, the comprehensive measurement of small molecules in biological samples, has the potential to reveal novel noninvasi
Autor:
Jason Gibson, David S. Hsu, Jeongeun Hyun, Anna Mae Diehl, Simon G. Gregory, Richard T. Premont, Cynthia D. Guy, Mark L. Jewell, Kuo Du, Seh-Hoon Oh, Thomas J. Ribar
Publikováno v:
Am J Pathol
Fibrolamellar carcinoma (FLC) is characterized by in-frame fusion of DnaJ heat shock protein family (Hsp40) member B1 (DNAJB1) with protein kinase cAMP-activated catalytic subunit α (PRKACA) and by dense desmoplasia. Surgery is the only effective tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db7b8fb52946e0d6a93a78c380043659
https://europepmc.org/articles/PMC10069284/
https://europepmc.org/articles/PMC10069284/
Autor:
Rohit, Loomba, Brent A, Neuschwander-Tetri, Arun, Sanyal, Naga, Chalasani, Anna Mae, Diehl, Norah, Terrault, Kris, Kowdley, Srinivasan, Dasarathy, David, Kleiner, Cynthia, Behling, Joel, Lavine, Mark, Van Natta, Michael, Middleton, James, Tonascia, Claude, Sirlin, Tanya, Wolfson
Publikováno v:
Hepatology
BACKGROUND AND AIMS Emerging data from a single-center study suggests that a 30% relative reduction in liver fat content as assessed by magnetic resonance imaging-proton density fat fraction (MRI-PDFF) from baseline may be associated with histologic
Autor:
Franklin G. Berger, Balaraman Kalyanaraman, Anna Mae Diehl, Varun Chandrashekaran, Jacek Ziolenka, Diptadip Dattaroy, Firas Alhasson, James A. Carson, Ratanesh Seth, Saurabh Chatterjee
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 8-19 (2017)
Redox Biology
Redox Biology
Recent clinical studies found a strong association of colonic inflammation and Inflammatory bowel disease (IBD)-like phenotype with NonAlcoholic Fatty liver Disease (NAFLD) yet the mechanisms remain unknown. The present study identifies high mobility
Autor:
Rasha Younis, Zhiyong Mi, Anna Mae Diehl, Paul C. Kuo, Marzena Swiderska-Syn, Naoto Kitamura, D. Reid, Lee C. Claridge, Lars P. Bechmann, Kosha J. Mehta, Jason D. Coombes, Karine Gauthier, Paul Manka, G. Gerken, MA Briones, W.-K. Syn, F Flamant, Ali Canbay, Bertus Eksteen, Roger Williams
Publikováno v:
Zeitschrift für Gastroenterologie. 54:1343-1404
Thyroid hormone (TH) signaling is critical for tissue-organ development, growth, differentiation and metabolism, and in the liver, the most widely expressed TH receptor is TRβ. In a recent study of patients with nonalcoholic steatohepatitis (NASH),