Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Andrew J. Gifford"'
Autor:
Laura D. Gamble, Ricky W. Johnstone, Klaartje Somers, Rachael L. Terry, Glenn M. Marshall, Andrei V. Gudkov, Sophie Allan, Georgina L. Eden, Jamie I. Fletcher, Frances K. Kusuma, Stephanie Alfred, Mawar Karsa, Adam Kearns, Michelle J. Henderson, Michelle Haber, Angelika Bongers, Katerina Gurova, Lin Xiao, Anahid Ehteda, Lei Zhai, Erin Mosmann, Katerina I. Leonova, Natalia Issaeva, Pooja Venkat, Aisling O'Connor, Alvin Kamili, David S. Ziegler, Ruby Pandher, Daniel R. Carter, Hazel Quek, Andrew J. Gifford, Jayne Murray, Chelsea Mayoh, Jessica A. Pettitt, Murray D. Norris, Jennifer Brand, Emma Ronca, Anthony J. Cesare
Publikováno v:
Clin Cancer Res
Purpose: We investigated whether targeting chromatin stability through a combination of the curaxin CBL0137 with the histone deacetylase (HDAC) inhibitor, panobinostat, constitutes an effective multimodal treatment for high-risk neuroblastoma. Experi
Autor:
Amanda J. Russell, Giovanni Perini, Stefania Purgato, André Oberthuer, Bing Liu, Federico M. Giorgi, Georgina L. Eden, Denise M. T. Yu, Sara Sarraf, Murray D. Norris, Michelle Haber, Emanuele Valli, Giorgio Milazzo, Claudia Flemming, Belamy B. Cheung, Simone Di Giacomo, Laura D. Gamble, Jamie I. Fletcher, David S. Ziegler, Toby Trahair, Sophie Allan, Glenn M. Marshall, Lin Xiao, Wendy B. London, Matthias Fischer, Michael D. Hogarty, Andrew J. Gifford, Jayne Murray, Daniel R. Carter, Alvin Kamili, Kimberley M. Hanssen, Chelsea Mayoh, Mark R. Burns
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Amplification of the MYCN oncogene is associated with an aggressive phenotype and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb20b9e495505924dcea7e7bf9a99d5
https://hdl.handle.net/10453/135528
https://hdl.handle.net/10453/135528
Autor:
William Stevenson, Anthony J. Gill, Oliver Giles Best, Grace Gifford, Sara Gabrielli, Qian Chen, Yandong Shen, Andrew J. Gifford
Publikováno v:
Leukemialymphoma. 61(8)
Fatty acid synthesis is crucial in supporting the survival and proliferation of multiple forms of cancer. The high metabolic demands of fatty acid synthesis are regulated by the AMP-activated kinase and activity of the fatty acid synthase enzyme. In
Autor:
Tim Failes, Meera Warby, Marie Wong, Emily Mould, Andrew J. Gifford, Jayne Murray, Carmela De Santo, Klaartje Somers, Olga B. Chernova, Toby Trahair, Jamie I. Fletcher, Andrei V. Gudkov, Tracey A. O'Brien, Katerina Gurova, Michelle J. Henderson, Laura D. Gamble, Lin Xiao, Murray D. Norris, Maria Tsoli, Glenn M. Marshall, Kathryn Evans, Loretta Lau, Lioubov G. Korotchkina, Ruby Pandher, Richard B. Lock, Denise Yu, Anthony J. Cesare, Mark J. Cowley, Paul G Ekert, Laura Franshaw, Anahid Ehteda, Greg M. Arndt, Marie-Emilie A. Gauthier, Jinhan Xie, Katherine M. Tucker, Paulette Barahona, Sumanth Nagabushan, Aisling O'Connor, Paul Cheng, Amit Kumar, Dylan Grebert-Wade, Aaminah Khan, Alexandra Sherstyuk, Patrick Strong, Chelsea Mayoh, Noemi Fuentes Bolanos, David S. Ziegler, Michelle Haber, Mark R. Burns, David Thomas, Dong Anh Khuong Quang, Francis Mussai, Alvin Kamili, Vanessa Tyrrell
Publikováno v:
Cancer Research. 80:IA13-IA13
Despite the increase in overall child cancer survival rates, pediatric malignancies such as high-risk neuroblastoma, high-risk leukemias (including MLL-translocated infant ALL), and aggressive brain tumors (including DIPG) remain refractory to curren
Autor:
Nagore G. Olaciregui, Tammy Hennika, Oren J. Becher, Angel M. Carcaboso, Kelly L. Barton, Maria Tsoli, David S. Ziegler, Arjanna Chitranjan, Anahid Ehteda, Andrew J. Gifford, Guo Hu, Cecilia Chang
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169485 (2017)
PLoS ONE
PLoS ONE
Background Diffuse intrinsic pontine glioma (DIPG), or high-grade brainstem glioma (BSG), is one of the major causes of brain tumor-related deaths in children. Its prognosis has remained poor despite numerous efforts to improve survival. Panobinostat
Autor:
Norris, Larry H. Matherly, Teah L. Witt, Jeffrey W. Taub, Andrew J. Gifford, Whetstine, Michelle Haber
Publikováno v:
Leukemia. 16:2379-2387
Resistance to the antifolate methotrexate (MTX) can cause treatment failure in childhood acute lymphoblastic leukemia (ALL). This may result from defective MTX accumulation due to alterations in the human reduced folate carrier (hRFC) gene. We have i
Autor:
Maria Kavallaris, Michelle Haber, Janice Madafiglio, Bernard W. Stewart, Murray D. Norris, Larry H. Matherly, Andrew J. Gifford
Publikováno v:
International Journal of Cancer. 78:176-181
We have previously described a series of methotrexate (MTX)-selected CCRF-CEM sublines (CEM/MTX R1–3) displaying increased resistance to drugs associated with the multidrug resistance phenotype and have provided evidence that MDR1 P-glycoprotein co