Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
John W. Tobias, Mario Andres Blanco, Snahlata Singh, Sushil Kumar, Alana L. Welm, Christopher J. Lengner, Rumela Chakrabarti, Yibin Kang, Christian W. Siebel, Andres J. Klein-Szanto, Ajeya Nandi, Rohan Regulapati, Ning Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Development of chemoresistance in breast cancer patients greatly increases mortality. Thus, understanding mechanisms underlying breast cancer resistance to chemotherapy is of paramount importance to overcome this clinical challenge. Although activate
Publikováno v:
Biochemical Pharmacology. 164:336-341
Hypercholesterolemia represents a leading cause in the development of atherosclerotic plaques, increasing the risk for ACVS. It actually counts as a major cause of cardiovascular disease etiopathogenesis. The causes of hypercholesterolemia are multif
Autor:
Jennifer R. Pyle, V. Craig Jordan, Andres J. Klein-Szanto, Helen Kim, Joan S. Lewis-Wambi, Chris Wambi, Roshani R. Patel
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-3 (2018)
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Introduction Estrogen deprivation using aromatase inhibitors is one of the standard treatments for postmenopausal women with estrogen receptor (ER)-positive breast cancer. However, one of the consequences of prolonged estrogen suppression is acquired
Publikováno v:
Molecular Carcinogenesis. 54:1122-1131
PACE4 (PCSK6) is a proprotein convertase (PC) capable of processing numerous substrates involved in tumor growth, invasion, and metastasis. Because of the human relevancy of the tobacco-associated carcinogen benzo[a]pyrene (B(a)P) we investigated whe
Autor:
Joseph R. Testa, Jacqueline Talarchek, Erin Neumann-Domer, Deborah A. Altomare, Yue Wu, Craig W. Menges, Guang-Hui Xiao, Vihren N. Kolev, Yuwaraj Kadariya, Irina M. Shapiro, Jonathan A. Pachter, Andres J. Klein-Szanto
Publikováno v:
Cancer Research. 74:1261-1271
Malignant mesothelioma is a highly aggressive, asbestos-related cancer frequently marked by mutations of both NF2 and CDKN2A. We demonstrate that germline knockout of one allele of each of these genes causes accelerated onset and progression of asbes
Autor:
Miriam N. Lango, Brian L. Egleston, Carolyn Y. Fang, Jamie L. Studts, Margret B. Einarson, Dana H. Bovbjerg, John A. Ridge, Andres J. Klein-Szanto, Barbara Burtness
Publikováno v:
Head & Neck. 36:1113-1119
Background Psychosocial functioning is associated with vascular endothelial growth factor (VEGF) in various patient populations. This study examined whether psychosocial functioning in patients with head and neck squamous cell carcinoma (HNSCC) is as
Autor:
Lionel Larue, Florian Rambow, Marisa S. Bartolomei, Tiziana Bruno, Dominique Kobi, Salvatore Cortellino, Christophe Alberti, Alfonso Bellacosa, Irwin Davidson, Jinfei Xu, Yoshihiro Matsumoto, Antonio Cigliano, Mara Sannai, Maurizio Fanciulli, Lara K. Abramowitz, Andy Wessels, Dianne Robert Soprano, Karthik Devarajan, Andres J. Klein-Szanto, Elena Caretti, Madeleine Le Coz, Catherine Renner, Robert Moore, Maria Rosaria Bassi
Publikováno v:
Cell. 146:67-79
SummaryDNA methylation is a major epigenetic mechanism for gene silencing. Whereas methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions in mammalian genomes are protected from de novo methylation and whether an a
Autor:
Heiner Westphal, Zhe-Sheng Chen, Alex Grinberg, Timothy Churchill, Emmanuelle Nicolas, Chelsy Paulose, Andres J. Klein-Szanto, Elizabeth Hopper-Borge, Yehong Kuang, Gary D. Kruh, Martin G. Belinsky, Joely D. Jacobs, Olivia Ngo
Publikováno v:
Cancer Research. 71:3649-3657
Recently, we reported that the ATP-binding cassette transporter 10 (ABCC10), also known as multidrug resistance protein 7 (MRP7), is able to confer resistance to a variety of anticancer agents, including taxanes. However, the in vivo functions of the
Autor:
Masami Hayashi, Deborah A. Altomare, Kimihiko Ito, Kenjiro Sawada, Yoshito Terai, Joseph R. Testa, Robert A. Burger, Chiaki Kawase, Andres J. Klein-Szanto, Tadashi Kimura, Yukihiro Nishio, Seiji Mabuchi, Masahide Ohmichi, Ken-ichirou Morishige
Publikováno v:
Molecular Cancer Therapeutics. 9:2411-2422
This study examines the role of vascular endothelial growth factor (VEGF) as a therapeutic target in clear cell carcinoma (CCC) of the ovary, which has been regarded as a chemoresistant histologic subtype. Immunohistochemical analysis using tissue mi
Autor:
Takeo Hara, Kelly A. Whelan, Takashi Kijima, Tomoki Makino, Prasanna M. Chandramouleeswaran, Haruna Furukawa, Andres J. Klein-Szanto, Shoji Natsugoe, Hiroshi Nakagawa, Yuta Kasagi, Yuichiro Doki, Makoto Yamasaki, Koji Tanaka, Masataka Shimonosono, Masaki Mori
Publikováno v:
Cancer Research. 78:5026-5026
Introduction: Esophageal squamous cell carcinoma (ESCC) is the deadliest of all human cancers with alcohol (EtOH) as a major risk factor. Malignant properties of ESCC have been attributed to ESCC cells with high CD44 expression (CD44H) and autophagy;