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pro vyhledávání: '"William Y. Kim"'
Autor:
William G. Kaelin, William Y. Kim
Publikováno v:
Seminars in Oncology. 33:588-595
The VHL tumor-suppressor gene is mutated or silenced in most clear cell renal carcinomas (RCCs). pVHL loss results in the stabilization of the heterodimeric transcription factor hypoxia-inducible factor (HIF) and enhanced transactivation of HIF targe
Autor:
Jennifer Valiando, Keiichi Kondo, Mircea Ivan, Adrian Salic, Haifeng Yang, John M. Asara, William G. Kaelin, Michael Ohh, William Y. Kim, William S. Lane
Publikováno v:
Science. 292:464-468
HIF (hypoxia-inducible factor) is a transcription factor that plays a pivotal role in cellular adaptation to changes in oxygen availability. In the presence of oxygen, HIF is targeted for destruction by an E3 ubiquitin ligase containing the von Hippe
Autor:
Mark A. Socinski, Christine M. Walko, Michael Chiu, Stephen A. Bernard, Anastasia Ivanova, Nirav Dhruva, Layla R. Hilbun, Kimberly Keller, Janine M. Davies, Thomas E. Stinchcombe, William Y. Kim, E. Claire Dees, D. Neil Hayes
Sorafenib has demonstrated single agent activity in non-small cell (NSCLC) and small cell lung cancer (SCLC). Carboplatin/pemetrexed (CbP) and cisplatin/etoposide (PE) are commonly used in the treatment of these diseases.A phase I trial escalating do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05a11cb762a5fded0073d956ba2c2dc
Autor:
William G. Kaelin, William Y. Kim, Aria F. Olumi, Susanne Schlisio, Qin Yan, Xiaoping Zhang, Liang Zhang, Yoji Andrew Minamishima, Haifeng Yang, Benjamin L. Ebert
Publikováno v:
Molecular cell. 28(1)
The VHL tumor suppressor protein (pVHL) is part of an E3 ubiquitin ligase that targets HIF for destruction. pVHL-defective renal carcinoma cells exhibit increased NF-kappaB activity but the mechanism is unclear. NF-kappaB affects tumorigenesis and th
Autor:
William G. Kaelin, William Y. Kim
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 22(24)
Germline inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene causes the von Hippel-Lindau hereditary cancer syndrome, and somatic mutations of this gene have been linked to the development of sporadic hemangioblastomas and clear-cell re