Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Eun Joo Kim"'
Publikováno v:
Oncogene. 37(3)
Retinoic acid (RA) has broad clinical applications for the treatment of various cancers, particularly acute promyelocytic leukemia. However, RA-based therapy is limited by relapse in patients associated with RA resistance, the mechanism of which is p
Publikováno v:
Biochemical and Biophysical Research Communications. 444:605-610
Transcriptional activity of the retinoic acid receptor (RAR) is regulated by diverse binding partners, including classical corepressors and coactivators, in response to its ligand retinoic acid (RA). Recently, we identified a novel corepressor of RAR
Publikováno v:
Molecular Cell. 51(2):200-210
Despite the importance of retinoic acid (RA) signaling and histone monoubiquitination in determining cell fate, the underlying mechanism linking the two processes is poorly explored. We describe that additional sex comb-like 1 (ASXL1) represses RA re
Publikováno v:
Biochemical and Biophysical Research Communications. 427:41-46
Retinoic acid (RA) plays pleiotropic roles in cellular differentiation and animal development. RA responses are mediated by transcriptional activation by the retinoic acid receptor (RAR) and retinoid X receptor (RXR) in cooperation with various types
Publikováno v:
Biochemical and Biophysical Research Communications. 404:239-244
Retinoic acid (RA) plays a role in cancer therapy. However, its long-term treatment is hindered by the acquired resistance which is not fully understood. Our previous study indicated that the transcriptional activity of RA receptor (RAR) is enhanced
Autor:
Eun Seong Hwang, Eun-Joo Kim, Moo Rim Kang, Hyun Tae Kang, Sang-Wang Lee, Soo-Jong Um, Elisa Um
Publikováno v:
Nucleic Acids Research
Human sirtuin 1 (SIRT1) is a NAD(+)-dependent deacetylase that participates in cell death/survival, senescence and metabolism. Although its substrates are well characterized, no direct regulators have been defined. Here, we show that SIRT1 associates
Publikováno v:
The EMBO Journal. 26:3545-3557
We isolated MED25, which associates with retinoic acid (RA)-bound retinoic acid receptor (RAR) through the C-terminal nuclear hormone receptor (NR) box/LxxLL motif, and increases RAR/RXR-mediated transcription. When tethered to a promoter, MED25 show
Autor:
Hong-Sig Sin, Si-Ho Park, Youn-Ja Kwon, Young-Soy Rho, Eun-Joo Kim, Hye-Sook Han, Soo-Jong Um
Publikováno v:
International Journal of Cancer. 109:58-64
Fenretinide, 4-(N-hydroxyphenyl) retinamide (4-HPR), has demonstrated anticancer activity associated with a favorable toxicity profile and is now being investigated in several clinical trials. However, its plasma levels in patients have been far lowe
Publikováno v:
Cancer letters. 331(2)
Retinoids including all-trans retinoic acid (RA) have been widely used for cancer therapy. However, the major obstacle for RA therapy is the acquired resistance of which mechanism remained obscure thus far. Here, we first identified Zyxin that cooper
Publikováno v:
The Journal of biological chemistry. 285(44)
In most mammalian cells, the retinoic acid receptor (RAR) is nuclear rather than cytoplasmic, regardless of its cognate ligand, retinoic acid (RA). In testis Sertoli cells, however, RAR is retained in the cytoplasm and moves to the nucleus only when