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Publikováno v:
Pharmacology Biochemistry and Behavior. 152:90-96
Preclinical psychopharmacology research needs novel behavioral indices and improved animal models for both sexes. The forced swim test (FST) is the most popular test for screening antidepressant potential. Sex differences in FST behaviors, such as im
Publikováno v:
Alcoholism: Clinical and Experimental Research. 40:1100-1110
Background Increased levels of impulsivity are associated with increased illicit drug use and alcoholism. Previous research in our laboratory has shown that increased levels of delay discounting (a decision-making form of impulsivity) are related to
Publikováno v:
Alcoholism: Clinical and Experimental Research. 39:2022-2031
Background The P2X4 receptor (P2X4R) is thought to be involved in regulating alcohol-consuming behaviors, and ethanol (EtOH) has been reported to inhibit P2X4Rs. Ivermectin is an antiparasitic agent that acts as a positive allosteric modulator of the
Autor:
James M. Reno, Neha Thakore, Rueben A. Gonzales, Christine L. Duvauchelle, W. Todd Maddox, Timothy J Schallert, Richard L. Bell
Publikováno v:
Alcoholism: Clinical and Experimental Research. 39:843-852
Background Emotional states are often thought to drive excessive alcohol intake and influence the development of alcohol use disorders. To gain insight into affective properties associated with excessive alcohol intake, we utilized ultrasonic vocaliz
Autor:
Judy E. Richards, Allen D. Ledbetter, William O. Ward, Urmila P. Kodavanti, Ronald Thomas, Daniel L. Costa, Mette C. Schladweiler
Publikováno v:
Inhalation Toxicology. 27:39-53
The molecular bases for variability in air pollutant-induced pulmonary injury due to underlying cardiovascular (CVD) and/or metabolic diseases are unknown. We hypothesized that healthy and genetic CVD-prone rat models will exhibit exacerbated respons
Publikováno v:
Alcoholism: Clinical and Experimental Research. 38:2607-2614
Background Increased levels of delay discounting have been associated with alcoholism and problematic levels of drinking. Attempts to assess the directionality of this relationship by studying individuals with a family history of alcoholism as well a
Autor:
Yi-Hsun Chen, Chien-Chao Chiu, Yi-Chih Chang, Wen-Ching Huang, Shao-Wen Hung, Hsiao-Li Chuang, Yu-Chih Wang, Yen-Te Huang
Publikováno v:
Toxins; Volume 9; Issue 7; Pages: 224
Toxins, Vol 9, Iss 7, p 224 (2017)
Toxins
Toxins, Vol 9, Iss 7, p 224 (2017)
Toxins
Pseudomonas aeruginosa exotoxin A (PEA) causes severe hepatotoxicity in experimental animals and is useful in investigations of immune-mediated liver injury. However, strain differences in the sensitivity to PEA-induced hepatotoxicity in rats remains
Autor:
James M. Reno, W. Todd Maddox, Neha Thakore, Nitish Mittal, Christine L. Duvauchelle, Richard L. Bell, Timothy J Schallert
Publikováno v:
Alcohol (Fayetteville, N.Y.). 68
Ultrasonic vocalizations (USVs) are mediated through specific dopaminergic and cholinergic neural pathways and serve as real-time measures of positive and negative emotional status in rodents. Although most USV studies focus primarily on USV counts,
Autor:
Howard J. Edenberg, William J. McBride, Zheng-Ming Ding, Zachary A. Rodd, Jeanette N. McClintick, Richard L. Bell, Mark W. Kimpel, Sheketha R. Hauser
Publikováno v:
Alcohol. 47:367-380
The objective of this study was to detect changes in gene expression in the ventral tegmental area (VTA) following repeated excessive binge-like (‘loss-of-control') alcohol drinking by alcohol-preferring (P) rats. Adult female P rats ( n = 7) were
Publikováno v:
Experimental and Toxicologic Pathology. 65:211-217
We examined the sequential histopathological changes in the placenta from rats exposed to cisplatin. Cisplatin was intraperitoneally administered at 2 mg/kg/day during GDs 11-12 (GD11,12-treated group), or GDs 13-14 (GD13,14-treated group), and the p