Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Irene M. Ghobrial"'
Autor:
Judith Runnels, Kenneth C. Anderson, Yazan Alsayed, Teru Hideshima, Irene M. Ghobrial, Aldo M. Roccaro, Alissa Huston, David Roodman, Yu Tsu Tai, Nikhil C. Munshi, Peter Sportelli, Xavier Leleu, Judy Anderson, Paul G. Richardson, Anne Moreau, Xiaoying Jia, Evdoxia Hatjiharissi, Sonia Vallet, Hai T. Ngo
Publikováno v:
Clinical Cancer Research. 14:865-874
Purpose: We hypothesized that targeting both Akt and heat shock protein (HSP) 90 would induce cytotoxic activity against multiple myeloma (MM) cells and target the bone marrow (BM) microenvironment to inhibit angiogenesis, osteoclast formation, as we
Autor:
Irene M. Ghobrial, Anne-Sophie Moreau, Judith Runnels, Antonio Sacco, Xavier Leleu, Feda Azab, Phong Quang, Molly R. Melhem, Mena Farag, Hai Ngo, Aldo M. Roccaro, Emanuel N. Husu, Nicholas Burwick, Xiaoying Jia, Abdel Kareem Azab
Within the past few years, major advances in the preclinical and clinical testing of novel therapeutic agents have occurred in Waldenstrom's macroglobulinemia (WM). These include agents that target the PI3K/Akt/mTOR pathway, PKC pathways, NF-kB signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c5b05345c43f07a54c9f0fc22812e4
https://europepmc.org/articles/PMC3133646/
https://europepmc.org/articles/PMC3133646/
Autor:
Xavier Leleu, Domenico Russo, Steven P. Treon, Bryan Ciccarelli, Lian Xu, Xiaoying Jia, Irene M. Ghobrial, Aldo M. Roccaro, Christopher J. Patterson, Anne-Sophie Moreau, Kenneth C. Anderson, Hai T. Ngo, Evdoxia Hatjiharissi, Antonio Sacco, Franco Dammacco, Angelo Vacca
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 14(6)
Purpose: Resveratrol (3,4',5-tri-hydroxy-trans-stilbene) is an antioxidant constituent of a wide variety of plant species including grapes. It has gained considerable attention because of its anticancer properties, as shown in solid and hematologic m
Autor:
Irene M. Ghobrial, Mena Farag, Evdoxia Hatjiharissi, Xavier Leleu, Feda Azab, Aldo M. Roccaro, Jérôme Eeckhoute, Judith Runnels, Antonio Sacco, Thomas E. Witzig, Abdel Kareem Azab, Hai T. Ngo, Kenneth C. Anderson, Xiaoying Jia, Myles Brown, Zachary R. Hunter, Teru Hideshima, Molly R. Melhem, Anne Moreau, Daniel R. Carrasco, Nicolas Burwick, Steven P. Treon
Publikováno v:
Blood. 111(10)
The nuclear factor-κB (NF-κB) path-way has been implicated in tumor B-cell survival, growth, and resistance to therapy. Because tumor cells overcome single-agent antitumor activity, we hypothesized that combination of agents that target differentia
Autor:
Irene M. Ghobrial, Douglas W. McMillin, Charles P. Lin, Aldo M. Roccaro, Garrett O’Sullivan, Mena Farag, Xiaoying Jia, Ruben D. Carrasco, Xavier Leleu, Daisy Moreno, Anne-Sophie Moreau, Tanyel Kiziltepe, Kenneth C. Anderson, Costas Pitsillides, Hai T. Ngo, Teru Hideshima, Joel A. Spencer, Steven P. Treon, Judith Runnels, Evdoxia Hatjiharissi
Waldenstrom macroglobulinemia (WM) is an incurable low-grade lymphoplasmacytic lymphoma. We demonstrate up-regulated Akt activity in WM, and that Akt down-regulation by Akt knockdown and the inhibitor perifosine leads to significant inhibition of pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6235a244709a333cb081b89cc949b4e
https://europepmc.org/articles/PMC2234792/
https://europepmc.org/articles/PMC2234792/
Autor:
Phong Quang, Kenneth C. Anderson, Irene M. Ghobrial, Judith Runnels, Antonio Sacco, Aldo M. Roccaro, Nicolas Burwick, Abdel Kareem Azab, Mena Farag, Molly R. Melhem, Xiaoying Jia, Hai T. Ngo, Xavier Leleu, Feda Azab, Yu-Tzu Tai
Publikováno v:
Blood. 112:2615-2615
BACKGROUND: Tyrosine phosphorylation is a central event in the regulation of a variety of biological processes such as cell proliferation, migration, adhesion, and survival. Waldenström Macroglobulinemia (WM) is an incurable lymphoplasmacytic lymph
Autor:
Marybeth Nelson, Renee Leduc, Irene M. Ghobrial, Peter Sportelli, Paul G. Richardson, Steven P. Treon, KC Anderson, Xavier Leleu, Stacey Chuma, Nancy Rubin
Publikováno v:
Journal of Clinical Oncology. 26:8546-8546
8546 Background: Perifosine is an oral, synthetic alkylphospholipid, with multiple effects including inhibition of Akt. We previously showed that perifosine induces significant growth inhibition in...
Resveratrol Exerts Antiproliferative Effect and Induces Apoptosis in Waldenstrom’s Macroglobulinemia
Autor:
Steven P. Treon, Anne-Sophie Moreau, Bryan Ciccarelli, Kenneth C. Anderson, Irene M. Ghobrial, Xavier Leleu, Antonio Sacco, Angelo Vacca, Aldo M. Roccaro, Franco Dammacco, Christopher J. Patterson, Lian Xu, Evdoxia Hatjiharissi, Sophia Adamia, Domenico Russo
Publikováno v:
Blood. 110:1383-1383
Background: Resveratrol is a polyphenolic natural product, synthesized by a wide variety of plant species including grapes. It has gained considerable attention because of its anti-cancer properties, as demonstrated in solid and haematological malign
Autor:
Irene M. Ghobrial, Aldo M. Roccaro, Xiaoying Jia, Anne-Sophie Moreau, Zachary R. Hunter, Kenneth C. Anderson, Teru Hideshima, Evdoxia Hatjiharissi, Judith Runnels, Antonio Sacco, Xavier Leleu, Feda Azab, Eeckhoute Jerome, Hai T. Ngo, Mena Farag, Peter Sportelli, Steven P. Treon, Abdel Kareem Azab
Publikováno v:
Blood. 110:2512-2512
Background: The NF-kB pathway has been implicated in tumor survival and growth, and to induce resistance to conventional agents. Because of the natural ability of tumor cells to overcome single agent antitumor activity, we hypothesized that targeting
Autor:
Xavier Leleu, Ruben D. Carrasco, Judith Runnels, Kenneth C. Anderson, Yu-Tsu Tai, Anne-Sophie Moreau, Evdoxia Hatjiharisi, Teru Hideshima, Xiaoying Jia, Hai Ngo, Garrett O’Sullivan, Steven P. Treon, Irene M. Ghobrial
Publikováno v:
Blood. 108:2416-2416
Background: We have previously demonstrated activity of the new Akt inhibitor perifosine (NSC 639966; Keryx, NY) in Waldenstrom’s Macroglobulinemia (WM). Perifosine induced complete inhibition of Akt phosphorylation along with induction of apoptosi