Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Reinaldo N. Takahashi"'
Publikováno v:
Behavioural Pharmacology. 29:199-210
The factors that trigger the pathophysiology of Parkinson's disease (PD) are unknown. However, it is suggested that environmental factors, such as exposure to pesticides, play an important role, in addition to genetic predisposition and aging. Early
Publikováno v:
Pharmacology Biochemistry and Behavior. 136:82-86
The combination of alcohol with an energy drink (ED) is believed to contribute to risky alcohol-drinking behaviors, such as binge drinking. However, the long-term effects on cognition and reward function that are caused by the repeated binge-like ing
Autor:
Jesús Giraldo, Francisco Ciruela, James A. R. Dalton, Paulo A. de Oliveira, Adrià Ricarte, Reinaldo N. Takahashi, Víctor Fernández-Dueñas, Xavier Morató, Andréia S. Cunha, Christa E. Müller, Rui Daniel Prediger, Filipe C. Matheus, Marc López-Cano
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Tardive dyskinesia (TD) is a serious motor side effect that may appear after long-term treatment with neuroleptics and mostly mediated by dopamine D2 receptors (D2Rs). Striatal D2R functioning may be finely regulated by either adenosine A2A receptor
Publikováno v:
Journal of Psychopharmacology. 26:7-22
The study of endocannabinoid pharmacology has proceeded from the discovery of Δ9-tetrahydrocannabinol, the main psychoactive compound in Cannabis sativa, to the identification of an endogenous endocannabinoid system that is essential for physiologic
Autor:
Rui Daniel Prediger, Pablo Pandolfo, Daniel Fernandes, Vanessa Aranega Pires, Fabrício A. Pamplona, Reinaldo N. Takahashi
Publikováno v:
Behavioural Pharmacology. 20:134-145
The strain of spontaneously hypertensive rats (SHR) is considered a genetic model for the study of attention-deficit hyperactivity disorder (ADHD), as it displays hyperactivity, impulsivity and poorly sustained attention. Recently, we have shown the
Publikováno v:
Life Sciences. 77:693-706
The purpose of the present study was to investigate whether Lewis (LEW) and spontaneously hypertensive rats (SHR), characterized in numerous behavioral tests as strains with high-anxiety and low-anxiety, respectively, could differ in their sensitivit
Publikováno v:
European Journal of Pharmacology. 499:147-154
The anxiolytic property of ethanol is generally accepted to be an important motivational factor for its consumption and the development of alcohol dependence. Recent studies suggest that adenosine receptors mediate important actions of ethanol, such
Publikováno v:
European Journal of Pharmacology. 462:115-123
Some human and animal studies have demonstrated enhancement of memory processes when ethanol was administered immediately after training and subjects were later tested in the drug-free state. The aim of this study was to evaluate the effect of acute
Publikováno v:
Brain Research Bulletin. 55:101-106
The present study was carried out to test the possible effects of caffeine in improving the memory deficits observed in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP)-lesioned rats, an animal model of early stage Parkinson’s disease. Caffeine
Autor:
Fabricio A, Pamplona, Juliano, Ferreira, Octávio, Menezes de Lima, Filipe Silveira, Duarte, Allisson Freire, Bento, Stefânia, Forner, Jardel G, Villarinho, Luigi, Bellocchio, Luigi, Bellochio, Carsten T, Wotjak, Raissa, Lerner, Krisztina, Monory, Beat, Lutz, Claudio, Canetti, Isabelle, Matias, João Batista, Calixto, Giovanni, Marsicano, Marilia Z P, Guimarães, Reinaldo N, Takahashi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 109(51)
Allosteric modulation of G-protein–coupled receptors represents a key goal of current pharmacology. In particular, endogenous allosteric modulators might represent important targets of interventions aimed at maximizing therapeutic efficacy and redu