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Published in:
Canadian Journal of Physiology and Pharmacology. 100:412-421
Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors including central obesity, hypertension, insulin resistance, dyslipidemia, and hyperglyemia. MetS is found to be a positive predictor of cardiovascular morbidity and mortality. The
Published in:
Canadian Journal of Physiology and Pharmacology. 100:379-385
This study investigated the effects of irisin on vascular smooth muscle contractility in rat thoracic aorta, and the hypothesis that mitogen-activated protein kinase kinase (MEK1/2) signaling pathway, voltage-gated potassium (KV) channels, small-cond
Published in:
Animal Bioscience. 35:631-637
Objective Surface disinfection is important in the proper running of livestock farms. Howev-er, disinfection of farm equipment and facilities is difficult because they are made of different materials, besides having large surface areas and complex st
Author/Creator:
Carlo Eduardo Medina-Solís, Gilberto Castañeda-Hernández, Mario I. Ortiz, Victor Manuel Muñoz Pérez, Raquel Cariño-Cortés
Published in:
Canadian Journal of Physiology and Pharmacology. 100:306-313
The objective of the present study was to scrutinize the effect of nitric oxide (NO), cyclic GMP (cGMP), potassium channel blockers, and metformin on the citral-produced peripheral antinociception. The rat paw 1% formalin test was used to assess noci
Author/Creator:
Ling Chen, Yuling Qin, Han Wang, Lai Mi, Yue-Su Zhou, Fang Lin, Lei Li, Peiran Li, Wei Zhang, Dan Wang
Published in:
Clinical Hemorheology and Microcirculation. 80:219-231
OBJECTIVE: This study aimed to explore the clinical detection and prognosis of coagulation function in patients with liver failure and sepsis. METHODS: The plasma fibrinogen (FIB), factor II, factor VII, factor V, factor IV, antithrombin III (ATIII),
Author/Creator:
Enrique F. Schisterman, Weihua Guan, Edwina Yeung, Alexandra C. Purdue-Smithe, Sonia L. Robinson, Sifang Kathy Zhao, Karen C. Schliep, Sunni L. Mumford, Robert M. Silver, Kristen Polinski
Published in:
Am J Clin Nutr
Background Epigenetic mechanisms may underlie associations between maternal caffeine consumption and adverse childhood metabolic outcomes. However, limited studies have examined neonate DNA methylation (DNAm) patterns in the context of preconception
Published in:
Nitric Oxide. 118:17-25
AIMS Patients with type 2 diabetes mellitus (T2DM) have reduced vasodilatory responses during exercise partially attributable to low nitric oxide (NO) levels. Low NO contributes to greater α-adrenergic mediated vasoconstriction in contracting skelet
Published in:
Bioactive Materials, Vol 7, Iss, Pp 227-241 (2022)
Bioactive Materials
Bioactive Materials
Obesity is a complex and incompletely understood disease, but current drug screening strategies mostly rely on immature in vitro adipose models which cannot recapitulate it properly. To address this issue, we developed a statistically validated high-
Author/Creator:
Roberto Laureano-Melo, Vivian de Assunção Nogueira Carvalho, Gabriela Mastrangelo Gonçalves, Thayane Ferreira da Costa Fernandes, Bruno Guimarães Marinho, Saulo Luis Capim, Joyce Mattos de Oliveira, Mário L. A. A. Vasconcellos, Gabriela de Carvalho Cid, Wellington da Silva Côrtes
Published in:
Clinical and Experimental Pharmacology and Physiology. 49:419-431
Pain is responsible for inducing physical and mental stress, interfering negatively in patients' quality of life. Classic analgesic drugs, such as opioids and non-steroidal anti-inflammatory drugs, are known for their wide range of adverse effects, m
Author/Creator:
Nadeem Sayyed, Imran Kazmi, Syed Sarim Imam, Waleed H. Almalki, Muhammad Nadeem, Mohammed M. Ghoneim, Fahad A. Al-Abbasi, Sultan Alshehri, Muhammad Afzal
Published in:
ACS Chemical Neuroscience. 12:4587-4597
The phytogenic flavanol component of the plant Rhusverniciflua Stokes is fustin which is implicated in various disease aliments and has promising therapeutic efficacy and a long history of its uses in the Indian medicinal system. The present study in