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Publikováno v:
Research Journal of Pharmacy and Technology. :3905-3910
This research involved the conversion of sulfadiazine into compound 2-chloro-N-(4-(N-(pyrimidin-2-yl) sulfamoyl) phenyl) acetamide [A] through the reaction of sulfadiazine with chloroacetyl chloride in the presence of diethylamine in dimethylformamid
Publikováno v:
Research Journal of Pharmacy and Technology. :3689-3694
An increase in blood sugar levels is an indication of diabetes mellitus (DM). DM is a metabolic disease characterized by disorders of carbohydrate and fat metabolism due to impaired activity, insulin secretion or both. Alternatively, the body's inabi
Publikováno v:
Research Journal of Pharmacy and Technology. :3727-3732
Plant derived products play a vital role in preventing and treating various disease in humans. Tephrosia tinctoria is a plant belonging to the family Leguminosae, found to have antidiabetic and antioxidant activities. The study was aimed to investiga
Autor:
Amaal S. Sadiq, Entesar O. Al-Tamimi
Publikováno v:
Research Journal of Pharmacy and Technology. :3721-3726
The purpose of the study is to synthesize and characterize a new polytriazole derivative from polyacryloyl chloried, first reaction of polyacryloyl chloride with hydrazine hydrate in the presence of DMF as a solvent to obtained acid hydrazide (1) tha
Autor:
Teruhisa Tokunaga, Haruyuki Hongo, Kyoko Nakamura, Takako Nagao, Ichiro Koga, Tomomi Kitaichi, Akiko Fukuda, Yuko Maeno
Publikováno v:
Advances in Therapy
Introduction Dolutegravir (DTG), a novel HIV-integrase strand transfer inhibitor (INSTI), is usually used with multiple antiretrovirals (ARVs) for treatment of HIV. DTG is now approved as Tivicay tablets in over 120 countries and Triumeq combination
Autor:
Rachel F. Tyndale, Ahmed El-Boraie
Publikováno v:
Clinical Pharmacology & Therapeutics. 110:599-606
Smoking continues to be the leading preventable contributor to death worldwide. Twin studies have suggested a significant genetic contribution underlying most smoking behaviors (40-70% heritability estimates). Candidate gene studies of smoking phenot
Autor:
Jürgen Burhenne, Antje Blank, Gerd Mikus, Walter E. Haefeli, Kathrin I. Foerster, Mazyar Mahmoudi, Brit Silja Rohr
Publikováno v:
Clinical Pharmacokinetics
Background Factor Xa inhibitors (FXaIs) are increasingly used without having sufficient drug–drug interaction data. Using a microdosed cocktail methodology could support filling the knowledge gap quickly. Methods In a randomised crossover trial, we
Autor:
Chengwen Teng, Christopher R. Frei
Publikováno v:
Drugs - Real World Outcomes. 9:23-29
Ertapenem, cefepime, imipenem, ofloxacin, ceftazidime, clarithromycin, cefaclor, levofloxacin, linezolid, moxifloxacin, azithromycin, piperacillin–tazobactam, trimethoprim–sulfamethoxazole, metronidazole, ciprofloxacin, and cefuroxime are known t
Publikováno v:
Clinical Pharmacology in Drug Development
Pharmacokinetics, safety, and tolerability of abacavir 600 mg/dolutegravir 50 mg/lamivudine 300 mg were assessed in this phase 1, single‐arm, open‐label, single‐dose study in fasted healthy male (n = 4) and female (n = 8) participants of Japane
Publikováno v:
Hospital Pharmacy. 57:345-348
A 38-years-old female with an aortic valve replacement presented to an outside hospital (OSH) with fevers and malaise. Blood cultures revealed VRE which was resistant to linezolid, resistant to ampicillin, non-susceptible to daptomycin (MIC of 8 mcg/