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Publikováno v:
Cochrane Database Syst Rev
The Cochrane Library
The Cochrane Library
Inhaled antibiotics are commonly used to treat persistent airway infection with Pseudomonas aeruginosa that contributes to lung damage in people with cystic fibrosis. Current guidelines recommend inhaled tobramycin for individuals with cystic fibrosi
Autor:
Lorinda Simms, Shehkar Patil, David R. Gandara, Anders Mellemgaard, Raghunadharao Digumarti, Bonne Biesma, Johan Vansteenkiste, Mauro Zukin, Joachim von Pawel, Katherine P. Sugarman, Keunchil Park, Christian Manegold, Filippo de Marinis, Tuncay Göksel, Janusz Rolski, Piotr Serwatowski, Jin S. Lee, Giorgio V. Scagliotti, Ulrich Gatzemeier, Purvish M. Parikh
Publikováno v:
Journal of Clinical Oncology. 41:2458-2466
PURPOSE Cisplatin plus gemcitabine is a standard regimen for first-line treatment of advanced non–small-cell lung cancer (NSCLC). Phase II studies of pemetrexed plus platinum compounds have also shown activity in this setting. PATIENTS AND METHODS
Autor:
Chiara Finocchiaro, Simona Toscano, Salvatore Lo Fermo, Francesco Patti, Enrico Millefiorini, Eleonora Sgarlata, Clara Grazia Chisari
Publikováno v:
Current Neuropharmacology. 20:1978-1987
Background: Progressive Multifocal Leukoencephalopathy (PML) is an opportunistic infection caused by John Cunningham virus (JCV) reactivation, potentially associated with natalizumab (NTZ) treatment for Multiple Sclerosis (MS). The anti-JCV antibodie
Publikováno v:
Exp Clin Psychopharmacol
Experimental and clinical psychopharmacology, vol 30, iss 3
Experimental and clinical psychopharmacology, vol 30, iss 3
Research on nicotine metabolism has primarily focused on white adults. This study examined associations between nicotine metabolism, tobacco use, and demographic characteristics among Alaska Native adults who smoke cigarettes. Participants (N = 244)
Autor:
Daniel Moj, Nicola Ammer, Babette Aicher, Jan-Georg Wojtyniak, Thorsten Lehr, Michael Teifel, Herbert Sindermann, Hannah Britz, Nina Hanke
Zoptarelin doxorubicin is a fusion molecule of the chemotherapeutic doxorubicin and a luteinizing hormone-releasing hormone receptor (LHRHR) agonist, designed for drug targeting to LHRHR positive tumors. The aim of this study was to establish a physi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c5e9a18956370d7aca5ee1061fd910
Autor:
Elizabeth R. Gerstner, Julian He, Bruce R. Rosen, Michael Wenke, Pratik Talati, Eva-Maria Ratai, Tracy T. Batchelor, Melanie Fu, Anna Vaynrub, Ovidiu C. Andronesi, Isabel Arrillaga-Romany, Otto Rapalino, R. Gilberto Gonzalez, Mark Vangel, Mohamed El-Abtah, Akila Weerasekera, Daniel Kim, Jorg Dietrich, Yi-Fen Yen, Deborah Forst
Publikováno v:
Radiology
BACKGROUND: Patients with recurrent glioblastoma (GBM) are often treated with antiangiogenic agents, such as bevacizumab (BEV). Despite therapeutic promise, conventional MRI methods fail to help determine which patients may not benefit from this trea
Autor:
Rajendra P. Singh, Kimberly K. Adkison, Mark Baker, Ridhi Parasrampuria, Allen Wolstenholme, Mark Davies, Nicola Sewell, Cindy Brothers, Ann M. Buchanan
Publikováno v:
Pediatric Infectious Disease Journal. 41:230-237
BACKGROUND The World Health Organization (WHO) 2019 antiretroviral treatment guidelines recommend use of optimal treatment regimens in all populations. Dolutegravir-based regimens are the preferred first-line and second-line treatment in infants and
Autor:
Enrique F. Schisterman, Weihua Guan, Edwina Yeung, Alexandra C. Purdue-Smithe, Sonia L. Robinson, Sifang Kathy Zhao, Karen C. Schliep, Sunni L. Mumford, Robert M. Silver, Kristen Polinski
Publikováno v:
Am J Clin Nutr
Background Epigenetic mechanisms may underlie associations between maternal caffeine consumption and adverse childhood metabolic outcomes. However, limited studies have examined neonate DNA methylation (DNAm) patterns in the context of preconception
Autor:
Jeff P. Sharman, Peter Trask, Yeung-Chul Mun, Anthony Masaquel, Habte A. Yimer, Alexey V. Danilov, John M. Burke, Sunil Babu, Jia Li, Michael Boxer
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 22:121-128
Introduction: Longitudinal changes in health-related quality of life (HRQoL) are important in patients with chronic lymphocytic leukemia (CLL). GIBB (NCT02320487) is an open-label, single-arm phase II study of obinutuzumab (GA101; G) in combination w
Autor:
Julie Means-Powell, Luis Del Valle, Vandana G. Abramson, Claudia Sorrentino, Melinda Sanders, Ingrid A. Mayer, Debra A. Tonetti, Roohi Ismail-Khan, Samarpan Majumder, Richard M Lush, Lucio Miele
Publikováno v:
Clin Breast Cancer
Preclinical studies have demonstrated a complex cross-talk between Notch and estrogen signaling in ERα-positive breast cancer. Gamma-secretase inhibitors (GSIs) are investigational agents that block the cleavage and activation of Notch receptors. In