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Autor:
Daniel Moj, Nicola Ammer, Babette Aicher, Jan-Georg Wojtyniak, Thorsten Lehr, Michael Teifel, Herbert Sindermann, Hannah Britz, Nina Hanke
Zoptarelin doxorubicin is a fusion molecule of the chemotherapeutic doxorubicin and a luteinizing hormone-releasing hormone receptor (LHRHR) agonist, designed for drug targeting to LHRHR positive tumors. The aim of this study was to establish a physi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c5e9a18956370d7aca5ee1061fd910
Autor:
Cintia V Cruz, Paula Schaiquevich, Carlos A Pérez Montilla, Gabriela Reyes Valenzuela, Paulo Cáceres Guido, Facundo García Bournissen, Roberto Caraballo
Background: Cannabidiol (CBD) is a nonpsychoactive natural product that has been increasingly used as a promising new drug for the management of neurological conditions such as refractory epilepsy. Development of rapid and sensitive methods to quanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6450fcd9997e851e4532077b12d00108
https://doi.org/10.1097/ftd.0000000000000846
https://doi.org/10.1097/ftd.0000000000000846
Autor:
Caroline Flora Samer, Camille Lenoir, Amine Niederer, Jules Alexandre Desmeules, Victoria Rollason, Youssef Daali
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 1, Pp 30-43 (2022)
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 1, Pp 30-43 (2022)
Xenobiotics can interact with cytochromes P450 (CYPs), resulting in drug–drug interactions, but CYPs can also contribute to drug–disease interactions, especially in the case of inflammation, which downregulates CYP activities through pretranscrip
Publikováno v:
Clinical Pharmacology in Drug Development. 11:220-234
LYT-100 (deupirfenidone) is a selectively deuterated form of pirfenidone under development for the treatment of inflammatory and fibrotic diseases, including interstitial lung disease. Adverse events associated with antifibrotics can be a barrier to
Autor:
Ali Unlu, Gulsum Abusoglu, Fatma Humeyra Yerlikaya, Dilek Tezcan, Duygu Eryavuz Onmaz, Sema Yilmaz, Mustafa Onmaz, Sedat Abusoglu
Publikováno v:
Inflammopharmacology
Hydroxychloroquine has attracted attention in the treatment of COVID-19. Many conflicting findings have been reported regarding the efficacy and safety of this drug, which has been used safely in the rheumatological diseases for years. However, these
Publikováno v:
British Journal of Clinical Pharmacology. 88:1885-1896
Aim: Metamizole (dipyrone) is a prodrug not detectable in serum or urine after oral ingestion. The primary metabolite is 4-methylaminoantipyrine (4-MAA), which can be N-demethylated to 4-aminoantipyrine (4-AA) or oxidized to 4-formylaminoantipyrine (
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Microdialysis coupled to an analytical system can be used to continuously monitor unbound protein analytes in any biological fluid, tissue, or organ of animals. To date, no application of microdialysis has been performed to simultan
Autor:
Senthil Packiasabapathy, Michael A. Heathman, Senthilkumar Sadhasivam, Blessed W Aruldhas, Sara K. Quinney, Andrea R. Masters, Hongyu Gao, Brian R. Overholser, Reynold C. Ly
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 10, Pp 1183-1194 (2021)
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 10, Pp 1183-1194 (2021)
Methadone is a synthetic opioid used as an analgesic and for the treatment of opioid abuse disorder. The analgesic dose in the pediatric population is not well‐defined. The pharmacokinetics (PKs) of methadone is highly variable due to the variabili
Autor:
Rocco C. Venuto, Kathleen M. Tornatore, Joseph D. Consiglio, Calvin J. Meaney, Louise M. Cooper, Daniel A. Brazeau, Gregory E. Wilding
Publikováno v:
J Clin Pharmacol
Mycophenolic acid exhibits significant interpatient pharmacokinetic variability attributed to factors including race, sex, concurrent medications, and enterohepatic circulation of the mycophenolic acid glucuronide metabolite to mycophenolic acid. Thi
Autor:
Jacqueline Lovett, Ruin Moaddel, Irving W. Wainer, William Denk, Clinton G. Lauritsen, Eric S. Schwenk, Marc C. Torjman, Daniel Katz, Stephen D. Silberstein
Publikováno v:
J Clin Pharmacol
Patients with refractory chronic migraine have substantial disability and have failed many acute and preventive medications. When aggressive intravenous therapy is indicated, both lidocaine and (R,S)-ketamine infusions have been used successfully to