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Autor:
Pedro Eduardo Fröehlich, Flavio Pechanksy, Graciela Carlos, Fabiano Barreto, Renata Pereira Limberger, Eloisa Comiran
Publikováno v:
Biopharmaceutics & Drug Disposition. 42:3-11
Lisdexamfetamine (LDX) is a long-acting prodrug stimulant indicated for the treatment of attention-deficit/hyperactivity disorder (ADHD) and binge-eating disorder (BED) symptoms. In vivo hydrolysis of the LDX amide bond releases the therapeutically a
Publikováno v:
Therapeutic Drug Monitoring. 42:548-553
BACKGROUND The alkylating agent cyclophosphamide is used in chemotherapy regimens for various type of cancer. However, cyclophosphamide may lead to toxic side effects on the bladder, namely hemorrhagic cystitis, which can cause hematuria, and, potent
Autor:
Chen Siying, Lu Yuan, Xiaoqing Zhu, Yongjun Li, Yueting Li, Chuang Cao, Jie Pan, Liu Chunhua, Sun Jia, Liu Ting, Jing Huang, Shuai Zhang, Wang Yonglin
Publikováno v:
BMC Pharmacology & Toxicology
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-8 (2021)
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-8 (2021)
Background Aidi Injection (ADI), a Chinese herbal preparation with anti-cancer activity, is used for the treatment of hepatocellular carcinoma (HCC). Several clinical studies have shown that co-administration of ADI with doxorubicin (DOX) is associat
Autor:
Christina Kinast, Uwe Liebchen, Michael Zoller, Michael Paal, Florian M Arend, Sophie Rakete, Michael Vogeser, Christina Scharf, Ulf Schönermarck
Publikováno v:
Antibiotics, Vol 10, Iss 715, p 715 (2021)
Antibiotics
Volume 10
Issue 6
Antibiotics
Volume 10
Issue 6
Several studies have addressed the poor stability of meropenem in aqueous solutions, though not considering the main degradation product, the open-ring metabolite (ORM) form. In the present work, we elucidate the metabolic fate of meropenem and ORM f
Publikováno v:
Journal of Antimicrobial Chemotherapy
The Journal of antimicrobial chemotherapy, vol 76, iss 7
The Journal of antimicrobial chemotherapy, vol 76, iss 7
Background As global confirmed cases and deaths from coronavirus disease 2019 (COVID-19) surpass 100 and 2.2 million, respectively, quantifying the effects of the widespread treatment of remdesivir (GS-5734, Veklury) and the steroid dexamethasone is
Autor:
Gaoxiang Ai, Ziwei Huang, Juanjuan Cheng, Jianhui Xie, Huifang Zeng, Yuhong Liu, Yucui Li, Xiaoqi Huang, Jiannan Chen, Ziren Su
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Coptisine (COP) is a bioactive isoquinoline alkaloid derived from Coptis Chinemsis Franch, which is traditionally applied for the management of colitis. However, the blood concentration of COP was extremely low, and its gut microbiota-mediated metabo
Autor:
Neelesh Dewan, Vibha Shukla, Timothy J. Garrett, Miguel A. Perez-Pinzon, Kunjan R. Dave, Ashish K. Rehni, Holly M. Stradecki-Cohan, Tatjana Rundek, Kyle D Klingbeil, Kevin B. Koronowski
Publikováno v:
CNS Neuroscience & Therapeutics
Aims Exposure to recurrent hypoglycemia (RH) is common in diabetic patients receiving glucose‐lowering therapies and is implicated in causing cognitive impairments. Despite the significant effect of RH on hippocampal function, the underlying mechan
Autor:
Michael H. Baumann, Karolina E. Kolaczynska, Dino Luethi, Melanie Walter, Marius C. Hoener, Matthias E. Liechti, Bruce E. Blough, Masaki Suzuki, Kenner C. Rice
Publikováno v:
J Psychopharmacol
BACKGROUND: Amphetamine analogs with a 3,4-methylenedioxy ring-substitution are among the most popular illicit drugs of abuse, exerting stimulant and entactogenic effects. Enzymatic N-demethylation or opening of the 3,4-methylenedioxy ring via O-deme
Publikováno v:
Journal of Dietary Supplements. 17:53-66
This study evaluates the anti-hyperlipidaemic and antioxidant activities of hydro-ethanolic fruits extract of Capsicum frutescens in hyperlipidemia rats. The secondary volatile metabolite constitue...
Autor:
Gideon St.Helen, Delia A. Dempsey, Rachel F. Tyndale, Kathryn C Edwards, Neal L. Benowitz, Natalie Nardone, Evangelia Liakoni
Publikováno v:
Clin Pharmacol Ther
This study investigated the influence of the rate of nicotine metabolism, as indicated by the nicotine metabolite ratio (NMR), on tobacco dependence. We stratified 136 smokers on the basis of saliva NMR as fast (n = 65) and slow (n = 71) metabolizers