Zobrazeno 1 - 6
of 6
pro vyhledávání: '"David L. Huso"'
Autor:
Ming Zhao, David L. Huso, Zhe Zhang, Anirban Maitra, Yong Soon Chun, Takahiro Yoshida, Dipankar Pramanik, Vered Stearns, Michelle A. Rudek, Saraswati Sukumar, Venugopal Chenna, Seung-Mo Hong, Savita Bisht, Roeland F. de Wilde
Publikováno v:
Carcinogenesis. 33:2242-2249
Multiple lines of evidence support a role for curcumin in cancer chemoprevention. Nonetheless, despite its reported efficacy and safety profile, clinical translation of curcumin has been hampered by low oral bioavailability, requiring infeasible ‘m
Autor:
Amy Hacker-Prietz, Robert A. Casero, David L. Huso, Shervin Rabizadeh, Patrick M. Woster, Cynthia L. Sears, Andrew C. Goodwin, Xin Qun Wu, Christina E. DeStefano Shields, Shaoguang Wu, Tracy Murray-Stewart
Publikováno v:
Proceedings of the National Academy of Sciences. 108:15354-15359
It is estimated that the etiology of 20–30% of epithelial cancers is directly associated with inflammation, although the direct molecular events linking inflammation and carcinogenesis are poorly defined. In the context of gastrointestinal disease,
Autor:
Hongni Fan, Cynthia L. Sears, Christine M. Dejea, Shaoguang Wu, Benjamin B. Finard, Abby L. Geis, Xinqun Wu, Christina E. DeStefano Shields, David L. Huso, Elizabeth C. Wick, Kai Fu, June L. Chan, Ada J. Tam, Sara W. Van Meerbeke, Liam Chung, Fengyi Wan, Florencia McAllister, Erik Thiele Orberg, Payam Fathi, Andriana Lebid, Franck Housseau, Drew M. Pardoll, Jie Chen, Paul Metz, Sudipto Ganguly
Publikováno v:
Cell host & microbe, vol 23, iss 2
Summary Pro-carcinogenic bacteria have the potential to initiate and/or promote colon cancer, in part via immune mechanisms that are incompletely understood. Using Apc Min mice colonized with the human pathobiont enterotoxigenic Bacteroides fragilis
Autor:
Patrick M. Dolan, William O. Osburn, Thomas W. Kensler, Baktiar O. Karim, David L. Huso, Masayuki Yamamoto, Guosheng Liu
Publikováno v:
International Journal of Cancer. 121:1883-1891
Chronic inflammation has been associated with increased risk of developing cancer. The transcription factor NF-E2-related factor 2 (Nrf2) controls the expression of numerous antioxidative enzymes that have been shown to attenuate acute inflammation.
Publikováno v:
Nature cell biology. 7(7)
Telomeres protect chromosome ends from fusion, degradation and recombination. Loss of telomere function has opposite effects on tumorigenesis: apoptosis, which inhibits tumour growth, and genomic instability, which accelerates tumour formation. Here
Publikováno v:
Cancer Research. 72:3039-3039
Our research is directed at elucidating key transcriptional networks and underlying cellular pathways regulated by the high mobility group A1 (HMGA1) gene in refractory malignancies. Work from our group and others has shown that blocking HMGA1 interf