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Publikováno v:
Journal of Antimicrobial Chemotherapy. 76:1215-1220
Background Neisseria gonorrhoeae has developed resistance to all antimicrobials used to treat gonorrhoea, with even ceftriaxone being undermined. It is therefore important to examine any potential to redeploy older antimicrobials routinely used for o
Publikováno v:
Journal of Oncology Pharmacy Practice. 27:954-961
Colorectal cancer is one of the commonest malignancies worldwide. The estimated lifetime risk of the disease is about 5% with an incidence of one million new cases and 600,000 deaths worldwide every year. It is estimated that in 2019, approximately 1
Autor:
Shoko Hirose, Misako Ohkusu, Kyohei Shimoyama, Naruhiko Ishiwada, Hiromichi Hamada, Kumi Yasukawa, Nozomu Oshima, Jun-ichi Takanashi, Takafumi Honda, Makoto Fujimori
Publikováno v:
Journal of Infection and Chemotherapy. 27:103-106
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has become a pathogen of major importance in pediatric patients. CA-MRSA can cause skin and soft tissue infection in children and young active adults with no predisposing factor
Publikováno v:
Infection and Drug Resistance. 14:315-327
Yanbin Chang,* Daiqin Zhang,* Siqiang Niu, Qian Chen, Qiuxia Lin, Xiaobing Zhang Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China*These authors contributed equal
Autor:
Ariya Chindamporn, Saowaluck Yasri, Thira Sirisanthana, Romanee Chaiwarith, Tim R. Cressey, Navaporn Worasilchai, Quanhathai Kaewpoowat
Publikováno v:
Journal of Antimicrobial Chemotherapy. 76:1041-1045
ObjectivesTo assess the pharmacokinetic of itraconazole capsule formulation and its active metabolite, hydroxyitraconazole, in adults with HIV diagnosed with talaromycosis in an endemic area, and to evaluate the drug–drug interaction between itraco
Autor:
Xiao Han, Zhi-Ren Zhang, Xiao Yan, Qiu-Shi Wang, Chen Liang, Zhi-Chao Dong, Ming-Ming Wu, Yun-Long Zhang, Lei-Xin Zou, Chen Chen, Bo Zhang
Publikováno v:
Acta Pharmacol Sin
Aflibercept, as a soluble decoy vascular endothelial growth factor receptor, Which has been used as a first-line monotherapy for cancers. Aflibercept often causes cardiovascular toxicities including hypertension, but the mechanisms underlying afliber
Autor:
Nirmal Singh, Pankaj Bhatia
Publikováno v:
Fundamental & Clinical Pharmacology. 35:650-666
The present study investigates the effect of ozagrel, a selective thromboxane A2 (TXA2) inhibitor, in rat model of hyperhomocysteinemia (HHcy)-induced vascular cognitive impairment and dementia (VCID). Wistar rats were administered L-Methionine (1.7g
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-11 (2020)
Trials
Trials
Background Postherpetic neuralgia (PHN) is the most common complication attributed to herpes zoster, which involves the reactivation of residual varicella zoster virus. It has been reported previously that pre-emptive amitriptyline following acute he
Publikováno v:
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-13 (2020)
BMC Pharmacology & Toxicology
BMC Pharmacology & Toxicology
Background Hypertension is the the primary cause of diastolic heart failure. Oxidative stress plays an important role in cardiac diastolic dysfunction caused by hypertension. The occurrence of oxidative stress is related to the level of nitric oxide
Publikováno v:
OncoTargets and therapy
Most patients diagnosed with hepatocellular carcinoma (HCC) have advanced diseases, and many are not eligible for curative therapies. There is growing evidence suggesting that the combination treatment of PD-1/PD-L1 inhibitors and tyrosine kinase inh