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Publikováno v:
British Journal of Clinical Pharmacology. 88:166-177
Aims The aims of this work were to build a semi-mechanistic tumor growth inhibition (TGI) model for metastatic colorectal cancer (mCRC) patients receiving either cetuximab+chemotherapy or chemotherapy alone and to identify early predictors of overall
Publikováno v:
Indonesian Journal of Pharmacy, Pp 193-200 (2021)
Diabetes Type 2 can cause oxidative stress leading to the accumulation of reactive oxygen species. Soyferment-Tempeh, a fermented soybean product with aerobic and anaerobic R. oligosporus incubation has a high antioxidant content of isoflavones that
Publikováno v:
Tropical Journal of Pharmaceutical Research. 19:2591-2595
Purpose: To study the influence of N-acetylcysteine (NAC) on systemic lupus erythematosus (SLE) mice, and the mechanism(s) involved. Methods: Fourteen MRL/lpr SLE mice aged 5 weeks (mean weight = 20.35 ± 2.12 g) were divided into two 7-mouse groups:
Publikováno v:
Tropical Journal of Pharmaceutical Research. 19:1465-1471
Purpose: To study the possible mitigating effect of erdosteine (ERD) against methotrexate (MTX)-induced liver toxicity.Methods: Male albino Sprague-Dawley rats were randomly assigned to four groups of 8 rats each, viz, vehicle control, MTX (20 mg/kg
Publikováno v:
Tropical Journal of Pharmaceutical Research. 19:1249-1254
Purpose: To determine the anti-diabetic effect of a monoamine oxidase inhibitor (tranylcypromine) in sulphonyl urea-refractory rats with poorly-controlled blood glucose levels.Methods: Alloxan-induced diabetic Wistar rats were assigned to two groups
Autor:
Majd M Masadeh, Bashar Al-Taani, Zainah O Aburashed, Nasr Alrabadi, Karem H. Alzoubi, Majed M Masadeh
Publikováno v:
Clinical Pharmacology: Advances and Applications. 12:171-176
Background Ciprofloxacin is an antimicrobial that is commonly used to treat several types of infections. It exerts its antimicrobial activity through interfering with bacterial DNA replication and transcription, leading to increase oxidative stress a
Publikováno v:
Infection and Drug Resistance. 13:3145-3152
Purpose Iron is a necessary element for the growth of bacteria; however, there are limited iron sources known for these microorganisms yet. Intracellular iron is stored as ferritin from, which releases iron in a gradual and controlled manner. The pre
Autor:
Tiffany R Keepers, Suzannah M. Schmidt-Malan, Robin Patel, Alisa W Serio, Melissa J. Karau, Bobbi S. Pritt, Surya Chitra, Scott A. Cunningham, Jayawant N. Mandrekar
Publikováno v:
Antimicrobial Agents and Chemotherapy
Omadacycline, vancomycin, and rifampin, as well as rifampin combination therapies, were evaluated in an experimental rat model of methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis. All treatment groups had less MRSA recovered than sali
Initially adopted as a mucolytic about 60 years ago, the cysteine prodrug N-acetylcysteine (NAC) is the standard of care to treat paracetamol intoxication, and is included on the World Health Organization's list of essential medicines. Additionally,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ddff910eb914fa821f6fb47c44532a
https://doi.org/10.1016/j.pharmthera.2021.107916
https://doi.org/10.1016/j.pharmthera.2021.107916
Publikováno v:
Iraqi Journal of Pharmaceutical Sciences, Vol 29, Iss 1, Pp 260-267 (2020)
Both methotrexate and vitamin D3 are used in combination for the treatment of various diseases. The aim of this study is to highlight the effect of vitamin D3 on methotrexate-induced jejunum damage using biochemical and histopathological studies. Sev