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Autor:
Jun Li, Hong Zhou, Yan Yao, Junfa Yang, Ying Hu, Shuang Hu, Tao Xu, Shu-xian Wang, Jing-Li Min, Chen-chen Yang, Ze-Yuan Wei, Yin-Cui Wu, Liang-yun Li
Publikováno v:
Acta Pharmacol Sin
Acetaminophen (APAP) is one of the major causes of drug-induced acute liver injury, and ethanol may aggravate APAP-induced liver injury. The problem of ethanol- and APAP-induced liver injury becomes increasingly prominent, but the mechanism of ethano
Autor:
Adeoti F Mansour, Jover Bernard, Djohan Ferdinand, Niamkey Germaine, Camara-Cisse Massara, Reynaud Fabrice, Cristol Jean Paul, Dere Luc, Monde Aké Absalome, Koffi Konan Gervais, Badia Eric, Chantal Gauze
Publikováno v:
African Journal of Biochemistry Research. 15:49-59
Palm oil has long been incriminated in obesity, and this obesity would be responsible for the development of cardiac fibrosis, several authors have evoked the role of free radicals in the pathophysiological mechanism of the fibrotic response linked t
Autor:
Akihito Tsuji, Dai Manaka, Masato Kataoka, Masashi Fujii, Masahiro Takeuchi, Takanori Watanabe, Masato Nakamura, Wataru Ichikawa, Hiroshi Matsuoka
Publikováno v:
Targeted Oncology. 16:753-760
Regorafenib and trifluridine/tipiracil are standard third-line chemotherapies for colorectal cancer patients, but their efficacy is limited. Anti-epidermal growth factor receptor antibody rechallenge has been reported to be promising for patients who
Autor:
Thomas P. Lodise, Monique R Bidell
Publikováno v:
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 41:915-931
Oral tetracyclines have been used in clinical practice for over 60 years. One of the most common indications for use of oral tetracyclines is for treatment of adult outpatients with skin and soft infections (SSTIs), including acute bacterial skin and
Autor:
Karidia Diallo, Kogieleum Naidoo, Pravi Moodley, Benjamin Chimukangara, Rochelle Nicola Adams, Richard J Lessells, Nesri Padayatchi, Linda Dlamini, Halima Dawood, Melissa B. Hagen, Lavanya Singh, Sheldon Chetty, Mary Mogashoa, Indra Grigalionyte, Nonhlanhla Yende-Zuma, Wayne A Duffus, Sibonisile Buthelezi, Tulio de Oliveira, Jennifer Giandhari
Publikováno v:
AIDS Research and Therapy, Vol 18, Iss 1, Pp 1-8 (2021)
AIDS Research and Therapy
AIDS Research and Therapy
Background Introduction of tenofovir (TDF) plus lamivudine (3TC) and dolutegravir (DTG) in first- and second-line HIV treatment regimens in South Africa warrants characterization of acquired HIV-1 drug resistance (ADR) mutations that could impact DTG
Autor:
Chuan Li, Changan Sun, Guicheng Wu, Guozhong Gong, Yuexin Zhang, Jia Shang, Zhiliang Gao, Lihua Zhong, Enqiang Chen, Qinglong Jin, Xiaofeng Wen, Ling Xiao, Huafa Yin, Lvfeng Yao, Qiong Wu, Jinlin Hou, Daokun Yang, Yan Huang, Zhihong Liu, Shide Lin, Fengmei Wang, Qing Mao, Huanyu Gong, Junqi Niu, Peng Hu
Publikováno v:
Alimentary Pharmacology & Therapeutics. 54:1134-1149
BACKGROUND Tenofovir amibufenamide (TMF) can provide more efficient delivery than tenofovir disoproxil fumarate (TDF). AIM To compare the efficacy and safety of TMF and TDF for 48 weeks in patients with chronic hepatitis B (CHB). METHODS We performed
Publikováno v:
Journal of Antimicrobial Chemotherapy. 77:38-48
Objectives Increasing spread of resistance could jeopardize the use of antifolates against MRSA infections. Methods We compared the prevalence of phenotypic trimethoprim/sulfamethoxazole resistance in 20 534 clinical Staphylococcus aureus isolates (1
Publikováno v:
Clinical Drug Investigation. 41:885-894
Methicillin-resistant Staphylococcus aureus bloodstream infections (MRSAB) cause significant mortality, and often require extended antibiotic therapy. Vancomycin, the most common initial MRSAB treatment, carries significant monitoring burden and neph
Publikováno v:
J Acquir Immune Defic Syndr
Journal of acquired immune deficiency syndromes (1999), vol 88, iss 1
Journal of acquired immune deficiency syndromes (1999), vol 88, iss 1
BACKGROUND Tenofovir alafenamide (TAF) is increasingly used in HIV treatment, with or without agents that require pharmacologic boosters such as ritonavir/cobicistat. Boosters increase TAF levels, so the TAF dose is lowered in single-pill combination
Autor:
Abdulhakim Abubakar, Ezzeldin Mukthar Abdurahman, Yusuf Tanko, Abdullahi Balarabe Nazifi, Joseph Akpojo Anuka, Idris Mohammed Maje
Publikováno v:
Drug Metabolism and Personalized Therapy. 37:69-80
Objectives Chlorophytum alismifolium (C. alismifolium) tubers are used in the management of diabetes. This research evaluated the effect of ethylacetate extract of C. alismifolium (EACA) on microvascular complications and the possible association of