Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Pan Deng"'
Autor:
Jessie B. Hoffman, Bernhard Hennig, Maria P. Kraemer, Andrew J. Morris, Pan Deng, Xu-Sheng Li, Chunyan Wang, Michael C. Petriello
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 1, Pp 45-53 (2020)
J Lipid Res
J Lipid Res
Elevated circulating levels of ceramides (Cers) are associated with increased risk of cardiometabolic diseases, and Cers may play a causative role in metabolic dysfunction that precedes cardiac events, such as mortality as a result of coronary artery
Publikováno v:
Drug Metabolism and Disposition. 47:238-248
Nitrile group biotransformation is an unusual or minor metabolic pathway for most nitrile-containing drugs. However, for some cyanopyrrolidine dipeptidyl peptidase 4 (DPP-4) inhibitors (vildagliptin, anagliptin, and besigliptin, but not saxagliptin),
Autor:
Pan Deng, Yanan Cao, B. Mark Evers, Andrew J. Morris, Side Liu, Qing Ye, Chi Wang, Zhaohe Zhou, Yekaterina Y. Zaytseva, Qing-Bai She, Eun Y. Lee, Yubin Guo, Daheng He, Charles E. Schwartz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Dysregulation of polyamine metabolism has been linked to the development of colorectal cancer (CRC), but the underlying mechanism is incompletely characterized. Here, we report that spermine synthase (SMS), a polyamine biosynthetic enzyme, is overexp
Autor:
Michael C. Petriello, Jessie B. Hoffman, Chunyan Wang, Yipeng Sui, Changcheng Zhou, Andrew J. Morris, Bernhard Hennig, Pan Deng, M. Abdul Mottaleb
Publikováno v:
Environ Pollut
Exposure to some environmental pollutants increases the risk of developing inflammatory disorders such as steatosis and cardiometabolic diseases. Diets high in fermentable fibers such as inulin can modulate the gut microbiota and lessen the severity
Publikováno v:
Toxicol Appl Pharmacol
Polychlorinated biphenyl (PCB)126 and perfluorooctane sulfonic acid (PFOS) are halogenated organic pollutants of high concern. Exposure to these chemicals is ubiquitous, and can lead to potential synergistic adverse effects in individuals exposed to
Autor:
Timothy L. Scott, Anh-Thu Le, Teresa W.-M. Fan, Qiushi Sun, Ramon C. Sun, Pan Deng, Richard M. Higashi, Andrew N. Lane, Ye Yang, Marc O. Warmoes
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications
Nature Communications
Delivering isotopic tracers for metabolic studies in rodents without overt stress is challenging. Current methods achieve low label enrichment in proteins and lipids. Here, we report noninvasive introduction of 13C6-glucose via a stress-free, ad libi
Publikováno v:
Insect biochemistry and molecular biology. 94
Hormone receptor 4 (HR4) is involved in the regulation of 20-hydroxyecdysone (20E) biosynthesis and the mediation of 20E signaling during larval-pupal transition in a holometabolan Drosophila melanogaster , whereas it acts as a repressor in 20E-respo
Publikováno v:
Insect biochemistry and molecular biology. 85
Drosophila cap ‘n’ collar isoform C (CncC) and Kelch-like ECH associated protein 1 (Keap1) regulate metamorphosis by transcriptional control of a subset of genes involved in ecdysteroidogenesis, 20-hydroxyecdysone (20E) signaling, and juvenile ho
Publikováno v:
Drug Metabolism and Disposition. 41:430-444
3-n-Butylphthalide (NBP) is a cardiovascular drug currently used for the treatment of cerebral ischemia. The present study aims to investigate the metabolism, pharmacokinetics, and excretion of NBP in humans and identify the enzymes responsible for t
Publikováno v:
Drug Metabolism and Disposition. 39:1058-1069
Amiodarone is recognized as an effective drug in the treatment of arrhythmias. Previous experiments demonstrated that mono-N-desethylamiodarone (MDEA) was the major circulating metabolite in humans. In addition, dealkylation, hydroxylation, and deami