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Autor:
Daniel Moj, Nicola Ammer, Babette Aicher, Jan-Georg Wojtyniak, Thorsten Lehr, Michael Teifel, Herbert Sindermann, Hannah Britz, Nina Hanke
Zoptarelin doxorubicin is a fusion molecule of the chemotherapeutic doxorubicin and a luteinizing hormone-releasing hormone receptor (LHRHR) agonist, designed for drug targeting to LHRHR positive tumors. The aim of this study was to establish a physi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c5e9a18956370d7aca5ee1061fd910
Publikováno v:
Alcohol. 99:70-81
In male rats, physical contexts that are associated with alcohol can amplify the response to a discrete, alcohol-predictive conditioned stimulus (CS), and amplify prime-induced reinstatement. Here, we examined these effects as a function of biologica
Publikováno v:
Alcohol. 98:19-24
This research investigated variations in alcohol consumption by socioeconomic factors and hypertensive status in South Korean adults, aged ≥19 years. This is a secondary data analysis using the Korea National Health and Nutrition Examination Survey
Publikováno v:
Alcohol. 98:9-17
The involvement of immune checkpoint regulators (ICs) in alcohol-associated liver diseases (ALDs) is still largely unknown. Here, we analyzed the levels of 16 soluble ICs (sICs) in male patients with ALD to determine their clinical significance. The
Social dominance in monkeys: Lack of effect on ethanol self-administration during schedule induction
Autor:
Phillip M. Epperly, April T. Davenport, Paul W. Czoty, B.T. Stinson, Lindsey K. Galbo, James B. Daunais
Publikováno v:
Alcohol
Nonhuman primate models of alcohol use disorder (AUD) frequently utilize schedule-induced polydipsia to initiate ethanol drinking. Previous research has demonstrated that specific characteristics of drinking during the final phase of induction, in wh
Publikováno v:
NeuroToxicology. 88:168-177
Neuroinflammation has an essential role in various neurodegenerative diseases including Parkinson's disease (PD). Microglial activation as a result of neuroinflammation exacerbates the pathological consequences of the disease. The toxic effect of 1-m
Publikováno v:
Toxicology Letters. 354:56-64
The ototoxic mechanisms of cisplatin on the organ of Corti and spiral ganglion neurons have been extensively studied, while few studies have been focused on the stria vascularis (SV). Herein, we verified the functional and morphological impairment in
Autor:
Nicolas Elie, Christelle Delalande, Kieiv Resende Sousa de Moura, Hemily Batista-Silva, Fátima Regina Mena Barreto Silva, Keyla Rodrigues, Glen Van Der Kraak
Publikováno v:
Reproductive Toxicology. 107:10-21
This study investigated the in vitro and short-term in vivo effects of Bisphenol A (BPA) on testicular energy metabolism and morphology in the zebrafish (Danio rerio). Testes were incubated in vitro for 1 h or fish were exposed in vivo to BPA in the
Publikováno v:
NeuroToxicology. 88:1-13
Cognitive impairment or "chemobrain" is a troublesome adverse effect which had been increasingly reported by cancer patients after doxorubicin (DOX) chemotherapy. Notably, Hypertension, a very common comorbidity in cancer patients, could pose a great
Autor:
Rongxin Liao, Yingjie Wei, Guoquan You, Ling Ye, Zhongqiu Liu, Cong Xie, Zhijie Zheng, Ruopeng Yang, Lili Gan, Wanyu Hu
Publikováno v:
Toxicology Letters. 353:34-42
Gelsemine (GA), the principal alkaloid in Gelsemium elegans Benth, exhibits potent and specific antinociception in chronic pain without the induction of apparent tolerance. However, GA also exerts neurotoxicity and hepatotoxicity when overdosed, and