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Autor:
Martti Vorne, M. Alavaikko
Publikováno v:
Acta Pharmacologica et Toxicologica. 29:402-416
Rats were given 2 ml carbon tetrachloride per kg body weight subcutaneously 3 times a week. The development of liver changes was observed from histological specimens, and changes in the functional capacity of the liver were determined by measuring th
Autor:
Kaija Pyykkö
Publikováno v:
Acta Pharmacologica et Toxicologica. 53:401-409
In the liver microsomes of toluene-treated and control Sprague-Dawley rats (n=148, males and females aged 13–93 days), the contents of cytochrome P-450 and b5 and the activities of NADPH – cytochrome c reductase and four monooxygenases were studi
Autor:
Sadhna Srivastava, S.D. Gangolli, Michael A. Collins, Colin R. Stubberfield, John R. Foster, Brian G. Lake
Publikováno v:
Acta Pharmacologica et Toxicologica. 51:217-226
The oral administration of 500–2500 mg/kg/day dicyclohexyl phthalate (DCHP) to young male Sprague-Dawley rats for 7 days resulted in liver enlargement and induction of some parameters of hepatic xenobiotic metabolism. Additional studies indicated t
Autor:
Osamu Takahashi, Kogo Hiraga
Publikováno v:
Acta Pharmacologica et Toxicologica. 56:6-13
Rats and mice were fed a diet containing aspirin at levels of 0, 0.3, 0.6 and 1.2% for 1 and 4 weeks. Haemorrhagic death and/or haemorrhagic anaemia occurred in rats in a dose-dependent manner. Prothrombin and kaolin-activated partial thromboplastin
Publikováno v:
Environmental Toxicology. 23:169-183
In a combined repeated dose toxicity study with reproduction/developmental toxicity screening test, Crj:CD(SD)IGS rats were dosed with dinoseb, 2-sec-butyl-4,6-dinitrophenol, by gavage at 0 (vehicle), 0.78, 2.33, or 7.0 mg/kg bw/day. Six males per gr
Publikováno v:
Toxicology Letters. 163:121-129
The Organization for Economic Co-operation and Development (OECD) has initiated the development of new guidelines for the screening and testing of potential endocrine disrupters. The Hershberger assay is one of the assays selected for validation base
Autor:
Annie Pfohl-Leszkowicz, Michel Dubois, I. Gaou, D. Parent-Massin, S. de Jouffrey, Christian Coste
Publikováno v:
Food Additives and Contaminants. 22:1113-1119
The Oxygreen process is a new treatment approved by The French Food Safety Authority (AFSSA) as a processing aid for flour quality improvement, based on treatment by ozone, in a closed sequential batch reactor. This treatment takes place in the class
Autor:
Charles H. Turner, Sarah Weissing, Lucinda G. Carr, Alexander G. Robling, Lawrence Lumeng, Imranul Alam
Publikováno v:
Alcoholism: Clinical and Experimental Research. 29:1769-1776
Background: The association between moderate alcohol intake and elevated bone mineral density observed in several epidemiologic studies might result from common genetic pathway regulating both phenotypes. In this study, we determined whether there is
Autor:
Satoko Sakamoto, Mineo Takatsuki, Susumu Tateyama, Kanji Yamasaki, Shuji Noda, Ryoji Yamaguchi, Saori Takakura, Takako Muroi
Publikováno v:
Archives of Toxicology. 79:627-635
In vivo screening methods for detection of thyroid function modulators are now under development in many research laboratories. We assessed the applicability of the Hershberger assay protocol to screen for thyroid function modulators. In experiment 1
Autor:
Dong Gyu Kim, Hwan Goo Kang, Sang Hee Jeong, Joon Hyoung Cho, Jong Myung Park, Myung-Haing Cho
Publikováno v:
Toxicology. 199:219-230
Chlorpyrifos-methyl (CPM), an organophosphate insecticide, widely used for grain storage and agriculture, has been suspected as endocrine disrupter by a few in vitro studies. This study was performed to investigate the (anti-) estrogenicity and (anti