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Publikováno v:
Pharmacology Biochemistry and Behavior. 152:90-96
Preclinical psychopharmacology research needs novel behavioral indices and improved animal models for both sexes. The forced swim test (FST) is the most popular test for screening antidepressant potential. Sex differences in FST behaviors, such as im
Publikováno v:
Alcoholism: Clinical and Experimental Research. 39:2022-2031
Background The P2X4 receptor (P2X4R) is thought to be involved in regulating alcohol-consuming behaviors, and ethanol (EtOH) has been reported to inhibit P2X4Rs. Ivermectin is an antiparasitic agent that acts as a positive allosteric modulator of the
Autor:
Braulio Rojas, Mario Herrera-Marschitz, David Vásquez, Diego Lagos, Mario Rivera-Meza, María Elena Quintanilla, Yedy Israel
Publikováno v:
Neuropharmacology. 146
A number of pre-clinical studies have shown that brain-generated acetaldehyde, the first metabolite of ethanol, exerts reinforcing effects that promote the acquisition of ethanol intake, while chronic intake maintenance appears to be mediated by alco
Publikováno v:
Biochemical Pharmacology. 86:1614-1620
The present study was aimed at assessing the influence of noradrenergic innervation of the paraventricular nucleus (PVN) and the arcuate nucleus (ARC) of the brain hypothalamus on cytochrome P450 expression in the liver. DSP-4, a neurotoxin specific
Publikováno v:
International Immunopharmacology. 17:576-584
Background The prevalence of food allergy has increased dramatically during the last three decades, but currently there was no effective therapy except avoidance of allergen. This study aimed to investigate the effect of a modified Chinese herbal for
Autor:
Philip J. Cowen, Sarah E. Gartside
Serotonin has a facilitatory role in the role of prolactin and adrenocorticotropin (ACTH) secretion. The serotonin precursor 5-hydroxy-L-tryptophan (5-HTP) dose dependently (30-100 mg/kg i.p.) increased plasma prolactin and ACTH in the male rat. Prol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83e0218062c2963aea6ec600950c4bc
https://doi.org/10.1016/0014-2999(90)90407-w
https://doi.org/10.1016/0014-2999(90)90407-w
The effects of nine central 5-HT antagonists on food intake in free feeding male rats were examined. The 5-HT2 antagonists ritanserin and ketanserin and the selective 5-HT3 antagonists ICS 205-930 and MDL 72222 had no effect on food intake. In contra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d4cbc977c12d67216b545bc0f70ec6
https://doi.org/10.1007/bf00443413
https://doi.org/10.1007/bf00443413
Rats were given continuous infusions of (+)-4-propyl-9-hydroxynaphthoxazine (PHNO, 5 micrograms/h), a dopamine D-2 receptor agonist, using subcutaneous implants of ALZET osmotic minipumps. It was observed that tolerance occurred to the motor stimulan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8bd8a97dabb6d04d7039f78f9a0262
https://doi.org/10.1016/0014-2999(88)90037-4
https://doi.org/10.1016/0014-2999(88)90037-4
Publikováno v:
Liebenberg, N, Harvey, B H, Brand, L, Wegener, G & Brink, C B 2012, ' Chronic treatment with the phosphodiesterase type 5 inhibitors sildenafil and tadalafil display anxiolytic effects in Flinders Sensitive Line rats ', Metabolic Brain Disease, vol. 27, no. 3, pp. 337-340 . https://doi.org/10.1007/s11011-012-9284-z
There are conflicting results from behavioural studies regarding whether the activation or inhibition of the cGMP-nitric oxide (NO) pathway induces anxiolyticlike behaviour. Sildenafil, an inhibitor of cGMP-selective phosphodiesterase-5, increases an
Autor:
Yoshihiko Tagawa, Takahiro Kondo, Fumihiro Jinno, Toshiyuki Takeuchi, Satoru Asahi, Tomoo Itoh
Publikováno v:
Drug Metabolism and Disposition. 40:648-654
The pharmacokinetics of 4-amino-3-chlorophenyl hydrogen sulfate, M-III of resatorvid, in rats and dogs were investigated using radiolabeled M-III ([(14)C]M-III). The elimination half-life of (14)C in the plasma of rats was approximately 1/30 of that