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Autor:
Braulio Rojas, Mario Herrera-Marschitz, David Vásquez, Diego Lagos, Mario Rivera-Meza, María Elena Quintanilla, Yedy Israel
Publikováno v:
Neuropharmacology. 146
A number of pre-clinical studies have shown that brain-generated acetaldehyde, the first metabolite of ethanol, exerts reinforcing effects that promote the acquisition of ethanol intake, while chronic intake maintenance appears to be mediated by alco
Publikováno v:
Biochemical Pharmacology. 86:1614-1620
The present study was aimed at assessing the influence of noradrenergic innervation of the paraventricular nucleus (PVN) and the arcuate nucleus (ARC) of the brain hypothalamus on cytochrome P450 expression in the liver. DSP-4, a neurotoxin specific
Autor:
Yoshihiko Tagawa, Takahiro Kondo, Fumihiro Jinno, Toshiyuki Takeuchi, Satoru Asahi, Tomoo Itoh
Publikováno v:
Drug Metabolism and Disposition. 40:648-654
The pharmacokinetics of 4-amino-3-chlorophenyl hydrogen sulfate, M-III of resatorvid, in rats and dogs were investigated using radiolabeled M-III ([(14)C]M-III). The elimination half-life of (14)C in the plasma of rats was approximately 1/30 of that
Autor:
Harald Olsen
Publikováno v:
Acta Pharmacologica et Toxicologica. 50:67-74
The actylation of sulfanilamide and procainamide in suspensions of isolated rat parenchymal cells was studied in absence and presence of ethanol (33 mM), acetate (0.5–5 mM), citrate (4 mM), pyruvate (4 mM), and L(minus;)carnitine (2 mM). Ethanol tr
Publikováno v:
Acta Pharmacologica et Toxicologica. 47:355-358
The fluoride sensitivity, determined as effect on protein synthesis (incorporation of 14C-leucine), of liver and kidney cells in suspension culture was explored. The cells were freshly prepared by collagenase perfusion from rats given drinking water
Autor:
Martti Vorne, M. Alavaikko
Publikováno v:
Acta Pharmacologica et Toxicologica. 29:402-416
Rats were given 2 ml carbon tetrachloride per kg body weight subcutaneously 3 times a week. The development of liver changes was observed from histological specimens, and changes in the functional capacity of the liver were determined by measuring th
Autor:
Kaija Pyykkö
Publikováno v:
Acta Pharmacologica et Toxicologica. 53:401-409
In the liver microsomes of toluene-treated and control Sprague-Dawley rats (n=148, males and females aged 13–93 days), the contents of cytochrome P-450 and b5 and the activities of NADPH – cytochrome c reductase and four monooxygenases were studi
Publikováno v:
Acta Pharmacologica et Toxicologica. 57:279-284
An experimental long–term hepatotoxicity study of cyanamide in Sprague–Dawley and Wistar rats has been carried out. After six months oral administration of cyanamide (2,7 and 25 mg/kg/day) no significant histological changes have been observed in
Autor:
O Jalling, Christian Olsen
Publikováno v:
Acta Pharmacologica et Toxicologica. 54:327-332
The metabolic effects of metformin were compared to the effects of phenformin on isolated parenchymal liver cells from fed and fasted rats with ethanol or glycerol as the only substrate. Both biguanides caused a fall in the hepatic oxygen-consumption
Autor:
Sadhna Srivastava, S.D. Gangolli, Michael A. Collins, Colin R. Stubberfield, John R. Foster, Brian G. Lake
Publikováno v:
Acta Pharmacologica et Toxicologica. 51:217-226
The oral administration of 500–2500 mg/kg/day dicyclohexyl phthalate (DCHP) to young male Sprague-Dawley rats for 7 days resulted in liver enlargement and induction of some parameters of hepatic xenobiotic metabolism. Additional studies indicated t