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Autor:
Yoshihiko Tagawa, Takahiro Kondo, Fumihiro Jinno, Toshiyuki Takeuchi, Satoru Asahi, Tomoo Itoh
Publikováno v:
Drug Metabolism and Disposition. 40:648-654
The pharmacokinetics of 4-amino-3-chlorophenyl hydrogen sulfate, M-III of resatorvid, in rats and dogs were investigated using radiolabeled M-III ([(14)C]M-III). The elimination half-life of (14)C in the plasma of rats was approximately 1/30 of that
Publikováno v:
Acta Pharmacologica et Toxicologica. 47:355-358
The fluoride sensitivity, determined as effect on protein synthesis (incorporation of 14C-leucine), of liver and kidney cells in suspension culture was explored. The cells were freshly prepared by collagenase perfusion from rats given drinking water
Autor:
Sadhna Srivastava, S.D. Gangolli, Michael A. Collins, Colin R. Stubberfield, John R. Foster, Brian G. Lake
Publikováno v:
Acta Pharmacologica et Toxicologica. 51:217-226
The oral administration of 500–2500 mg/kg/day dicyclohexyl phthalate (DCHP) to young male Sprague-Dawley rats for 7 days resulted in liver enlargement and induction of some parameters of hepatic xenobiotic metabolism. Additional studies indicated t
Autor:
Masataka Majima, Makoto Katori
Publikováno v:
Journal of Pharmacological Sciences, Vol 100, Iss 5, Pp 370-390 (2006)
It is widely accepted that a high sodium intake triggers blood pressure rise. However, only one-third of the normotensive subjects were reported to show salt-sensitivity in their blood pressure. Many factors have been proposed as causes of salt-sensi
Autor:
Noriko Yamabe, Takako Yokozawa, Naotoshi Shibahara, Hirozo Goto, Yutaka Shimada, Dong Young Rhyn, Takako Nakagawa
Publikováno v:
Journal of Pharmacy and Pharmacology. 57:1205-1212
Diabetes mellitus is now the most common cause of end-stage renal failure. In this study, the effects of Hachimi-jio-gan on diabetic kidney damage in spontaneously diabetic WBN/Kob rats were examined. Oral administration of Hachimi-jio-gan to WBN/Kob
Publikováno v:
European Journal of Pharmacology. 468:217-224
The immunosuppressant drug cyclosporine causes nephrotoxicity mainly via alterations of renovascular reactivity. This study investigated whether this effect of cyclosporine is modulated by the male gonadal hormone testosterone. The endothelium-depend
Publikováno v:
Fundamental and Clinical Pharmacology. 16:9-14
The aim of this study was to evaluate whether thromboxane A2-prostaglandin H2 (TP) receptor activation potentiates the renal vasoconstrictor effect of Angiotensin II (Ang II) in genetically hypertensive rats of the Lyon strain (LH). Concentration-res
Autor:
J H, de Wilt, E R, Manusama, B, van Etten, S T, van Tiel, A S, Jorna, A L, Seynhaeve, T L, ten Hagen, A M, Eggermont
Publikováno v:
British Journal of Cancer
Nitric oxide (NO) is an important molecule in regulating tumour blood flow and stimulating tumour angiogenesis. Inhibition of NO synthase by L-NAME might induce an anti-tumour effect by limiting nutrients and oxygen to reach tumour tissue or affectin
Publikováno v:
Journal of Cardiovascular Pharmacology. 33:440-450
In a previous study, we showed that caffeine (CAFF) increases basal renin secretion by blocking intrarenal adenosine receptors and, when sympathetic activity is increased, augments renin release in part by blockade of brain adenosine receptors, leadi
Autor:
Takayuki Funakoshi, Morio Kiyozumi, Shoji Kojima, Hideaki Shimada, Hideaki Hirukawa, Yosuke Sugimura
Publikováno v:
Toxicology and Applied Pharmacology. 116:24-29
N-Benzyl- d -glucamine dithiocarbamate (BGD), N-p-isopropylbenzyl- d -glucamine dithiocarbamate (PBGD), and diethyldithiocarbamate (D (DED) were compared for their protective effects against the testicular toxicity in rats induced by acute exposure t