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Autor:
Hayk Ghukasyan, Thuy Le, Cecilia M. Shikuma, Nath Limpruttdham, Trieu Ly Vo, Lishomwa C. Ndhlovu, Louie Mar A Gangcuangco, Glen M. Chew, Thomas A. Premeaux, Robert H. Paul, Thao Vu Phuong, Dominic C. Chow, Van Vinh Chau Nguyen, Chathura Siriwardhana
Publikováno v:
AIDS Res Hum Retroviruses
The impact of HIV antiretroviral therapy (ART) on immune dysregulation associated with hepatitis C virus (HCV)/HIV coinfection is incompletely understood. We serially assessed monocyte activation (neopterin, sCD14, and sCD163) and T cell activation (
Autor:
Tracy Kellermann, Monica Gandhi, Eric H Decloedt, Gert U. van Zyl, Matthew A Spinelli, Zukiswa Nkantsu, Marije van Schalkwyk, Dolphina Cogill, Catherine Orrell, Lauren Jennings
Publikováno v:
AIDS Res Hum Retroviruses
Introduction The high cost of viral load (VL) testing limits its use for antiretroviral treatment (ART) adherence support. A low-cost lateral flow urine tenofovir (TFV) rapid assay predicts PrEP breakthroughs but has not yet been investigated in HIV
Publikováno v:
Virology Journal, Vol 18, Iss 1, Pp 1-10 (2021)
Virology Journal
Virology Journal
Background Different species of human rhinovirus (HRV) can induce varied antiviral and inflammatory responses in human blood macrophages and lower airway epithelium. Although human nasal epithelial cells (HNECs) are a primary infection route of HRV,
Autor:
Srikanth Tripathy, Shripad A. Patil, Partha Sarathi Mohanty, Tej Pal Singh, Avi Kumar Bansal, Sheetal Tomar, Srikanta Jena, Luke Elizabeth Hanna, Ramesh Karunaianantham, Rekha Tandon, Sushanta Kumar Barik, Sathyamoorthy Pattabiraman, Keshar Kunja Mohanty
Publikováno v:
AIDS Research and Human Retroviruses. 37:796-805
We aim to characterize the drug resistance mutations in reverse transcriptase gene of HIV-1 subtype C-infected North Indian population in those who are failing first-line antiretroviral therapy (ART) and if these mutations are associated with mortali
Autor:
Alinda G. Vos, Wdf Venter
Publikováno v:
Current Opinion in HIV and AIDS. 16:286-291
PURPOSE OF REVIEW HIV treatment has evolved since the introduction of antiretroviral therapy (ART) in the 1990s. Earlier treatment strategies, and the introduction of integrase inhibitors in preferred first-line ART have fundamentally changed cardiov
Publikováno v:
Current Opinion in HIV and AIDS. 16:279-285
Purpose of review To date, more than 30 antiretroviral drugs have been approved by the Food and Drug Administration for the treatment of HIV infection. As new drugs with better efficacy and safety profile become available for clinical practice, older
Autor:
Dongxin Liu, Wencong He, Jiale Fan, Chunfa Liu, Ping He, Yanlin Zhao, Yuanchun Li, Aijing Ma, Jingjing Bao, Qian Cheng, Yimeng Song, Bing Zhao
Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 26, Iss, Pp 241-248 (2021)
Objectives The new antituberculous drugs delamanid and bedaquiline form the last line of defence against drug-resistant tuberculosis (TB). Understanding the background prevalence of resistance to new drugs can help predict the lifetime of these drugs
Autor:
Francesca Lombardi, Davide Moschese, Anna D'Angelillo, Simona Di Giambenedetto, Arianna Emiliozzi, Alberto Borghetti, Chiara Picarelli, Damiano Farinacci, Alex Dusina, Arturo Ciccullo, Gianmaria Baldin
Publikováno v:
AIDS Research and Human Retroviruses. 37:429-432
We tried to investigate and compare the safety of a dual therapy (DT) with dolutegravir+lamivudine (DTG +3TC) versus bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF). We performed a retrospective analysis in a cohort of virologically sup
Autor:
Taisho Yamada, Hirofumi Sawa, Seiichi Sato, Akinori Takaoka, Yuki Sotoyama, Michihito Sasaki, Hajime Yamauchi, Yasuko Orba
Publikováno v:
Nature Immunology. 22:820-828
Efficient immune responses against viral infection are determined by sufficient activation of nucleic acid sensor-mediated innate immunity1,2. Coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a
Publikováno v:
J Virol
Viral antagonism of innate immune pathways is a common mechanism by which viruses evade immune surveillance. Infection of host cells with reovirus leads to the blockade of NF-{kappa}B, a key transcriptional regulator of the hosts innate immune respon