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Publikováno v:
Inflammation Research. 69:1039-1051
Mast cells are involved in not only inducing, but also maintaining neurogenic inflammation and neuropathic pain. In previous work, we have demonstrated that dehydroleucodine, xanthatin and 3-benzyloxymethyl-5H-furan-2-one inhibit rat peritoneal and h
Changes in choroidal structure following intravitreal aflibercept therapy for retinal vein occlusion
Autor:
Yoshinori Mitamura, Tserennadmid Enkhmaa, Taiji Sakamoto, Mariko Egawa, Fumiko Murao, Masanori Niki, Shozo Sonoda, Hiroki Sano
Publikováno v:
The British Journal of Ophthalmology
Aims To examine the choroidal change accompanying retinal vein occlusion (RVO) in detail, we measured changes in choroidal structure after intravitreal aflibercept (IVA) injections for RVO using binarisation of enhanced depth imaging optical coherenc
Publikováno v:
Journal of Biomedical Research & Environmental Sciences. 1:040-050
We suppose a hypothetical role of erythrocytes in COVID-19: Involvement of bone marrow; evidences of the presence of ferritins in the autoptic spleen; role of erythrocytes in the production of thrombosis; the reason of using chloroquine and heparin;
Publikováno v:
Brain, Behavior, and Immunity
Spiga, F, Zhao, Z & Lightman, S L 2020, ' Prolonged treatment with the synthetic glucocorticoid methylprednisolone affects adrenal steroidogenic function and response to inflammatory stress in the rat ', Brain, Behavior, and Immunity, vol. 87, pp. 703-714 . https://doi.org/10.1016/j.bbi.2020.03.001
Spiga, F, Zhao, Z & Lightman, S L 2020, ' Prolonged treatment with the synthetic glucocorticoid methylprednisolone affects adrenal steroidogenic function and response to inflammatory stress in the rat ', Brain, Behavior, and Immunity, vol. 87, pp. 703-714 . https://doi.org/10.1016/j.bbi.2020.03.001
Highlights • Prolonged MPRED treatment disrupts basal corticosterone ultradian rhythm. • Prolonged MPRED treatment decreases adrenal response to ACTH. • These effects are associated with decreased expression of steroidogenic proteins. • Prolo
Autor:
Shingo Nakayamada, Masanobu Ueno, Tong Zhang, Mingzeng Zhang, Maiko Hajime, Naoaki Ohkubo, Shigeru Iwata, Hiroko Miyata, Jie Fan, Kaoru Yamagata, Yasuyuki Todoroki, He Hao, Yoshiya Tanaka
Publikováno v:
Arthritis & Rheumatology. 72:1143-1153
Objective Plasmablasts play important roles in autoimmune diseases, including systemic lupus erythematosus (SLE). Activation of mechanistic target of rapamycin complex 1 (mTORC1) is regulated by amino acid levels. In patients with SLE, mTORC1 is acti
Publikováno v:
Inflammation. 43:1707-1715
Dexmedetomidine has been confirmed to have anti-inflammatory effect in numerous diseases. However, the detailed mechanism is still unknown. We explore the hypothesis that CD200R is related to the anti-inflammatory effect of dexmedetomidine. Primary m
Autor:
Andrew J. Henderson, Nicholas G. Martin, Busra Gok, Elliot C. Nelson, Masanao Yajima, John P. Cleary, Tanya T. Karagiannis, Christine S. Cheng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
Nature Communications
Chronic opioid usage not only causes addiction behavior through the central nervous system, but also modulates the peripheral immune system. However, how opioid impacts the immune system is still barely characterized systematically. In order to under
Autor:
Venkata G. Meka, Peter Barker, Stephanie Korn, James Zangrilli, Ubaldo J. Martin, Sameer K. Mathur, David A. Jackson
Publikováno v:
Drug Safety
Eosinophils play a pivotal role in the inflammatory pathology of asthma and have been the target of new biologic treatments for patients with eosinophilic asthma. Given the central role of interleukin (IL)-5 in the eosinophil lifecycle, several thera
Autor:
Rebecca Scherzer, Michelle M. Estrella, Kimberly A. Spaulding, Monica Gandhi, Robert M. Grant, Megha Mehrotra, Patricia Defechereux, Vasantha Jotwani, Simon B. Ascher, David V. Glidden, Judy K. Shigenaga, Michael G. Shlipak
Publikováno v:
AIDS
OBJECTIVE: To evaluate the effects of HIV pre-exposure prophylaxis (PrEP) with tenofovir disoproxial fumurate (TDF)/emtricitabine (FTC) on kidney function and kidney tubular health. DESIGN: The Iniciativa Profilaxis Pre-Exposicion open-label extensio
Publikováno v:
Allergology International, Vol 69, Iss 2, Pp 178-186 (2020)
IL-5 is the most potent activator of eosinophils and is produced by Th2 cells and ILC2s. A role for IL-5 in eosinophil extracellular trap cell death, i.e., a proinflammatory cell death, has also been reported. Mepolizumab and benralizumab are humaniz