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Autor:
Geraldine Cambridge, David A. Isenberg, Loren Kell, Samuel J Taylor, Maria J. Leandro, Kavina Shah, Ruth J Pepper, Venkat Reddy, Mark S. Cragg, Scott R. Henderson, Christian Klein
Publikováno v:
Rheumatology. 61:2894-2904
Objectives To investigate key factors that may contribute to the variability of rituximab-mediated peripheral and renal B cell depletion (BCD) in SLE. Methods We analysed: (i) CD19+ B cell counts in patients with SLE before and 1, 2, 3 and 6 months a
Autor:
V. I. Mazurov, M. A. Korolev, A. M. Prystrom, E. V. Kunder, N. F. Soroka, A. A. Kastanayan, T. V. Povarova, T. V. Plaksina, O. V. Antipova, D. G. Kretchikova, S. A. Smakotina, O. A. Tciupa, E. V. Puntus, T. A. Raskina, L. N. Shilova, T. V. Kropotina, O. B. Nesmeyanova, T. A. Popova, I. B. Vinogradova, Yu. N. Linkova, E. A. Dokukina, A. V. Plotnikova, P. S. Pukhtinskaia, A. V. Zinkina-Orikhan, A. V. Eremeeva, A. A. Lutckii
Publikováno v:
Современная ревматология, Vol 15, Iss 4, Pp 13-23 (2021)
Levilimab is anti-interleukin-6 receptor (IL6R) monoclonal antibody. The article presents data obtained during 24 weeks of the SOLAR phase III study.Objective: to confirm efficacy and safety of levilimab in combination with methotrexate (MTX) in pati
Publikováno v:
Inflammopharmacology. 29:1157-1168
STZ is a glucosamine-nitrosourea compound, causes dysfunctioning of insulin receptors in the brain and disrupts glucose metabolism, produces cognitive decline and AD-like symptoms. ICV injection of STZ causes accumulation of Aβ and cognitive dysfunc
Publikováno v:
Advances in Clinical and Experimental Medicine. 30:673-679
BACKGROUND Allergic rhinitis (AR) is a type I allergic reaction mediated by serum immunoglobulin E (IgE). OBJECTIVES This study aimed to investigate the basophil activation rate and serum expression of inflammatory factors in AR patients and rats. Th
A Milestone in Multiple Sclerosis Therapy: Monoclonal Antibodies Against CD20—Yet Progress Continues
Publikováno v:
Neurotherapeutics
Multiple sclerosis (MS), which is a chronic inflammatory disease of the central nervous system, still represents one of the most common causes of persisting disability with an early disease onset. Growing evidence suggests B cells to play a crucial r
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 15, Iss, Pp 1-8 (2021)
International Journal for Parasitology: Drugs and Drug Resistance, Vol 15, Iss, Pp 1-8 (2021)
Despite being considered one of the most pathogenic helminth infections of companion animals, members of macrocyclic lactone class are the only drugs available for the prevention of heartworm disease caused by Dirofilaria immitis. Alarmingly, heartwo
Publikováno v:
Современная ревматология, Vol 15, Iss 1S, Pp 1-62 (2021)
In systemic sclerosis (SSc), interstitial lung disease (ILD) is common (>80%) and worsens the prognosis of the disease, but severe progressive damage develops only in 8–10% of cases. Interstitial changes in the lungs occur early (within the first 3
Autor:
Venkata G. Meka, Peter Barker, Stephanie Korn, James Zangrilli, Ubaldo J. Martin, Sameer K. Mathur, David A. Jackson
Publikováno v:
Drug Safety
Eosinophils play a pivotal role in the inflammatory pathology of asthma and have been the target of new biologic treatments for patients with eosinophilic asthma. Given the central role of interleukin (IL)-5 in the eosinophil lifecycle, several thera
Autor:
Yufei Feng, Zhixin Yang, Zhong-xu Jing, Yanhong Wang, Shaowa Lv, Rui Wang, Yan-yan Zhang, Qingxia Guan
Publikováno v:
Chinese Herbal Medicines. 11:332-336
Objective Though especially efficient for cardiovascular and cerebrovascular diseases treatment, many serious anaphylactic diseases could be induced by Ciwujia Injection (CWJI). However, study of the mechanism and detection of allergies have been inv
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 35:235-244
Purpose: To investigate retinal gene expression of tetramethylpyrazine (TMP) eye drop-treated endotoxin-induced uveitis (EIU) in mice and to explore the mechanisms. Methods: The inflammato...