Zobrazeno 1 - 4
of 4
pro vyhledávání: '"David L. Huso"'
Autor:
Ming Zhao, David L. Huso, Zhe Zhang, Anirban Maitra, Yong Soon Chun, Takahiro Yoshida, Dipankar Pramanik, Vered Stearns, Michelle A. Rudek, Saraswati Sukumar, Venugopal Chenna, Seung-Mo Hong, Savita Bisht, Roeland F. de Wilde
Publikováno v:
Carcinogenesis. 33:2242-2249
Multiple lines of evidence support a role for curcumin in cancer chemoprevention. Nonetheless, despite its reported efficacy and safety profile, clinical translation of curcumin has been hampered by low oral bioavailability, requiring infeasible ‘m
A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome
Autor:
Hamid Ehsan, Mark J. Caulfield, Oliver Squires, Nick Huso, Djahida Bedja, Nicole K Wilson, Jefferson J. Doyle, Jennifer P Habashi, Florian Schoenhoff, Mark E. Lindsay, David L. Huso, Benjamin Rusholme, Craig J. Thomas, Suha Bachir, Daniel P. Judge, Alexander J Doyle, Loretha Myers, Ryan Whitworth, Harry C. Dietz, Jennifer E. Van Eyk
Publikováno v:
eLife
eLife, Vol 4 (2015)
Elife, 4
Doyle, Jefferson J; Doyle, Alexander J; Wilson, Nicole K; Habashi, Jennifer P; Bedja, Djahida; Whitworth, Ryan E; Lindsay, Mark E; Schönhoff, Florian; Myers, Loretha; Huso, Nick; Bachir, Suha; Squires, Oliver; Rusholme, Benjamin; Ehsan, Hamid; Huso, David; Thomas, Craig J; Caulfield, Mark J; Van Eyk, Jennifer E; Judge, Daniel P and Dietz, Harry C (2015). A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome. eLife, 4 eLife Sciences Publications 10.7554/eLife.08648
eLife, Vol 4 (2015)
Elife, 4
Doyle, Jefferson J; Doyle, Alexander J; Wilson, Nicole K; Habashi, Jennifer P; Bedja, Djahida; Whitworth, Ryan E; Lindsay, Mark E; Schönhoff, Florian; Myers, Loretha; Huso, Nick; Bachir, Suha; Squires, Oliver; Rusholme, Benjamin; Ehsan, Hamid; Huso, David; Thomas, Craig J; Caulfield, Mark J; Van Eyk, Jennifer E; Judge, Daniel P and Dietz, Harry C (2015). A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome. eLife, 4 eLife Sciences Publications 10.7554/eLife.08648
Calcium channel blockers (CCBs) are prescribed to patients with Marfan syndrome for prophylaxis against aortic aneurysm progression, despite limited evidence for their efficacy and safety in the disorder. Unexpectedly, Marfan mice treated with CCBs s
Autor:
James S.K. Sham, Terri H. Beaty, Gregg L. Semenza, Xing Sun, Aimee Y. Yu, Rita McWilliams, Larissa A. Shimoda, Charles M. Wiener, J. T. Sylvester, David L. Huso, Narayan V. Iyer
Publikováno v:
Journal of Clinical Investigation. 103:691-696
Chronic hypoxia induces polycythemia, pulmonary hypertension, right ventricular hypertrophy, and weight loss. Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding proteins that mediate adaptive responses to hypoxia, including
Autor:
Edward Gabrielson, Zhe Zhang, Lisa K. Jacobs, Vered Stearns, Stacie Jeter, Nagi F. Khouri, Scott L. Kominsky, Saraswati Sukumar, Theodore N. Tsangaris, Takahiro Yoshida, Michelle A. Rudek, David L. Huso, Karineh Tarpinian, Penny Powers, Regina J. Brown, Tsuyoshi Mori, Julie R. Lange
Publikováno v:
Science Translational Medicine. 3
Most breast cancers originate in the epithelial cells lining the breast ducts. Intraductal administration of cancer therapeutics would lead to high drug exposure to ductal cells and eliminate preinvasive neoplasms while limiting systemic exposure. We