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Autor:
Jie Qiao, Dongping Lin, Xiaoman Chen, Jing Sun, Lin Ye, Boren Jiang, Xiaofeng Tao, Qing Li, Chenfang Zhu, Ziyang Shao, Chunhua Sui, Yingli Lu, Ping Xiong, Hualing Zhai, Buatikamu Abudukerimu, Yubo Ma, Mengda Jiang, Bing Han, Ningjian Wang, Huifang Zhou, Qin Li
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 5, Pp 1734-1746 (2021)
Clinical and Translational Science
Clinical and Translational Science
Thyroid‐associated ophthalmopathy (TAO) is a serious, progressive, vision‐threatening and difficult‐to‐treat organ‐specific autoimmune disease. The course, therapeutic effects and prognosis of moderate to severe TAO vary greatly. High‐dos
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports
Scientific Reports
Nicotinic acetylcholine receptors (nAChRs) play a critical role in the neuropharmacology of learning and memory. As such, naturally occurring alkaloids that regulate nAChR activity have gained interest for understanding and potentially improving memo
Autor:
Masood A. Khan, Karen Brown, Michael A. Malfatti, Edwina N. Scott, William P. Steward, Emma Parrott, Robert G. Britton, Ted J. Ognibene, Hong Cai
Publikováno v:
The American Journal of Clinical Nutrition
Background The dietary polyphenol resveratrol prevents various malignancies in preclinical models, including prostate cancer. Despite attempts to translate findings to humans, gaps remain in understanding pharmacokinetic-pharmacodynamic relations and
Autor:
Sibel Laçinel Gürlevik, Bora Gülhan, Benan Bayrakci, Rezan Topaloglu, Yasemin Ozsurekci, Ali Bülent Cengiz, Pembe Derin Oygar, Seza Ozen, Selman Kesici, Eda Didem Kurt Şükür
Publikováno v:
Pediatric Nephrology (Berlin, Germany)
Background The rising number of infections due to Severe Acute Respiratory Syndrome Coronavirus-2 (popularly known as COVID-19) has brought to the fore new antiviral drugs as possible treatments, including favipiravir. However, there is currently no
Autor:
Eva-Lotte Lindstedt, Carl Amilon, Hans Ericsson, David Han, Maria Heijer, Carl Whatling, Karin Nelander, Li-Ming Gan, Erik Michaëlsson, Maria Lagerström-Fermér, Muir Russell, M Kjaer
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 3, Pp 812-819 (2021)
Clinical and Translational Science
Clinical and Translational Science
We evaluated safety, tolerability, pharmacokinetics (PKs), and pharmacodynamics of AZD4831, a novel oral myeloperoxidase (MPO) inhibitor, in a randomized, single-blind, placebo-controlled study, following once-daily multiple ascending dosing to stead
Autor:
Yuta Yokoyama, Yasuo Takeda, Norifumi Morikawa, Akari Shigemi, Tamao Ohshige, Kazuaki Matsumoto, Erika Watanabe, Kazuro Ikawa, Hideyuki Terazono, Yuki Enoki, Kayoko Matsubara
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:732-736
Ampicillin-sulbactam is a first-line therapy for pneumonia and is mainly excreted by the kidney. It is important to optimize the dose and dosing interval of ampicillin-sulbactam because in patients with decreased renal function and low skeletal muscl
Publikováno v:
NeuroToxicology. 84:208-217
Methamphetamine is used extensively around the world as a psychostimulant. The complications related to methamphetamine include methamphetamine-induced neurotoxicity, mainly involving intraneuronal processes, such as oxidative stress and excitotoxici
Publikováno v:
Endocrine, Metabolic & Immune Disorders - Drug Targets. 21:905-911
Objectives: 1,3,4-thiadiazole (A), 1,3,4-oxadiazole (B) and 1,2,4-triazole (C) derivatives have been known for their immense pharmacotherapeutic potential. The current research article attempts to further explore and understand the probable biochemic
Autor:
Krzysztof Palczewski, Alyaa Shmara, Timothy Ton, Cheng Cheng, Jesse D. Vargas, Marja Pitkänen, Virginia Kimonis, Lan Weiss, Teemu Turunen, Sama Saeid, Christopher L. Sander, Henri Leinonen, Lac Ta, Jianye Zhang, Ari Koskelainen
Publikováno v:
J Pharmacol Exp Ther
CB-5083 is an inhibitor of p97/valosin-containing protein (VCP), for which phase I trials for cancer were terminated because of adverse effects on vision, such as photophobia and dyschromatopsia. Lower dose CB-5083 could combat inclusion body myopath
Publikováno v:
Chemical Research in Toxicology. 34:1348-1354
Linezolid, the principal oxazolidinone antibiotic for therapy of Gram-positive infections, is limited by its myelosuppression and monoamine oxidase (MAO) inhibition, with the latter manifested as serotonergic neurotoxicity. The oral oxazolidinone con