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Autor:
Mingli Zuo, Yanfeng He, Yi Bao, Xiangyun Gai, Yongxin Liang, Pengcheng Lin, Dianxiang Lu, Gazang Zhaxi, Yuhua Ma, Cairang Nanjia, Zhanqiang Li, Xuehua Wu
Publikováno v:
Journal of Pharmacological Sciences, Vol 144, Iss 4, Pp 237-244 (2020)
Hypoxic pulmonary hypertension (HPH) is a progressive and irreversible disease that reduces survival. Echinacoside is a phenylethanoid glycoside from Tibetan herbs known for its vasorelaxant effect and for inhibiting the proliferation of rat pulmonar
Autor:
Peter B. Senese, Eric Zanelli, Kristian Agmund Haanes, Joseph Kovalchin, Ad J.J.C. Bogers, Antoinette MaassenVanDenBrink, Carlos M. Villalón, Alejandro Labastida-Ramírez, Antoon J. van den Bogaerdt, Kirk W. Johnson, Laurent Meeus, Eloísa Rubio-Beltrán, Michael R Gralinski, A.H. Jan Danser
Publikováno v:
British Journal of Pharmacology
British Journal of Pharmacology, 176(24), 4681-4695. Wiley-Blackwell
British Journal of Pharmacology, 176(24), 4681-4695. Wiley-Blackwell
Background and Purpose: Triptans are 5-HT1B/1D receptor agonists (that also display 5-HT1F receptor affinity) with antimigraine action, contraindicated in patients with coronary artery disease due to their vasoconstrictor properties. Conversely, lasm
Autor:
Juliana Maria Navia-Pelaez, Gianne P. Campos-Mota, Jessica Cristina Araujo-Souza, Luciano S. A. Capettini, Nikolaos Stergiopulos
Publikováno v:
Atherosclerosis. 258:108-118
Background and aims: Lysophosphatidylcholine (LPC) - a main component of oxidized LDL -is involved in endothelial dysfunction that precedes atherosclerosis, with an increased superoxide anions and a reduced NO production via endothelial NO synthase (
Publikováno v:
Journal of Pharmacological Sciences, Vol 140, Iss 1, Pp 48-53 (2019)
Nobiletin is a one of the polymethoxyflavones contained in the peel of citrus fruits, such as Citrus depressa. In this study, the effect of nobiletin-induced relaxation on phenylephrine (PE)-induced contraction of endothelium-denuded rat aorta was in
Publikováno v:
Journal of Vascular Surgery. 62:721-733
Venous function is underappreciated in its role in blood pressure determination, a physiologic parameter normally ascribed to changes in arterial function. Significant evidence points to the hormone endothelin-1 (ET-1) as being important to venous co
Autor:
Mun Fei Yam, Yung Sing Ch’ng, Chu Shan Tan, Mariam Ahmad, Mohd Zaini Asmawi, Yean Chun Loh, Wan Maznah Wan Omar
Publikováno v:
Journal of medicinal food. 21(3)
The seeds of Swietenia macrophylla King (SM) (Meliaceae) are used as a folk medicine for the treatment of hypertension in Malaysia. However, the antihypertensive and vasorelaxant effects of SM seeds are still not widely studied. Thus, this study was
Publikováno v:
Vascular pharmacology. 108
We aimed to determine the influence of nitrergic innervation function on the decreased mesenteric arterial tone induced by high levels of triiodothyronine (T3), as a model of acute thyroiditis, as well as the mechanism/s implicated. We analysed in me
Publikováno v:
Acta Physiologica Hungarica. 101:448-460
The present study was undertaken in order to examine transduction mechanism involved in the single application of 100 μM homocysteine (Hcy) on isolated rat femoral artery (RFA) rings equilibrated on the basal tone; to establish if a single applicati
Publikováno v:
Journal of Cardiovascular Pharmacology. 64:151-163
This study was aimed to offer a possible pharmacological basis regarding the remedial utilization of Wrightia tinctoria in hypertension and dyslipidemia in certain South Asian traditional systems of medicine, using in vivo and in vitro assays. The aq
Autor:
Maria Cristina Breschi, Lara Testai, Francesca G. Bellagambi, Alma Martelli, Silvia Ghimenti, Vincenzo Calderone, Valentina Citi, Alice Marino
Publikováno v:
Vascular pharmacology, Vol. 60, no.1, p. 32-41 (2014)
Hydrogen sulfide (H₂S) is an endogenous gasotransmitter, which mediates important physiological effects in the cardiovascular system. Accordingly, an impaired production of endogenous H₂S contributes to the pathogenesis of important cardiovascula