Zobrazeno 1 - 10
of 2 419
pro vyhledávání: ''
Autor:
Mingli Zuo, Yanfeng He, Yi Bao, Xiangyun Gai, Yongxin Liang, Pengcheng Lin, Dianxiang Lu, Gazang Zhaxi, Yuhua Ma, Cairang Nanjia, Zhanqiang Li, Xuehua Wu
Publikováno v:
Journal of Pharmacological Sciences, Vol 144, Iss 4, Pp 237-244 (2020)
Hypoxic pulmonary hypertension (HPH) is a progressive and irreversible disease that reduces survival. Echinacoside is a phenylethanoid glycoside from Tibetan herbs known for its vasorelaxant effect and for inhibiting the proliferation of rat pulmonar
Autor:
Shino Miyauchi-Wakuda, Yoshihiko Ito, Yuri Oonishi, Kazumasa Shinozuka, Yaoyue Liang, Satomi Kagota, Kana Maruyama, Shizuo Yamada
Publikováno v:
Biomedicine & Pharmacotherapy. 106:1210-1219
Aims Royal jelly (RJ) has a variety of reported biological activities, including vasorelaxation and blood pressure–lowering effects. Although functional foods are positively used for health, the effects of RJ on the cardiovascular system in healthy
Publikováno v:
American Journal of Physiology-Renal Physiology. 315:F123-F129
Glomerular hyperfiltration occurs during the early stage of diabetes. An acute glucose infusion increases glomerular filtration rate. The involvement of tubuloglomerular feedback response and direct effect of glucose on the afferent arterioles (Af-Ar
Publikováno v:
Cardiovascular Toxicology. 18:356-364
Phthalates are one of the main constituents of plastic, reaching up to 40% of the total plastic weight, and their main function is to impart flexibility/elasticity to polymers that would otherwise be rigid. Phthalates are known as endocrine disruptor
Autor:
Miodrag Janić, Mojca Lunder, Alenka France Štiglic, Aleš Jerin, Milan Skitek, Darko Černe, Janja Marc, Gorazd Drevenšek, Mišo Šabovič
Publikováno v:
Vascular Pharmacology. 99:45-52
Background Statins and sartans can, in therapeutic doses, induce pleiotropic cardiovascular effects. Similar has recently been shown also for sub-therapeutic doses. We thus explored and compared the cardiovascular pleiotropic efficacy of sub-therapeu
Autor:
Harry Z.E. Greenberg, Kazi S. Jahan, Anthony P. Albert, Alexander Zargaran, W-S Vanessa Ho, Dhanak M Khan, Simonette R E Carlton-Carew
Publikováno v:
Vascular Pharmacology
Stimulation of calcium-sensing receptors (CaSR) by increasing the external calcium concentration (Ca2 +]o) induces endothelium-dependent vasorelaxation through nitric oxide (NO) production and activation of intermediate Ca2 +-activated K+ currents (I
Publikováno v:
Metabolic Syndrome and Related Disorders. 15:233-239
Metabolic syndrome (MetS) facilitates the development of cardiovascular disease due to atherosclerosis, which is accelerated by defects of the vascular endothelium. Vascular dysfunction in response to nitric oxide (NO) occurs in the mesenteric arteri
Publikováno v:
Vascular Pharmacology. 91:36-41
Objective The balance between nitric oxide (NO)-sensitive and -insensitive forms of soluble guanylate cyclase (sGC) has been demonstrated to be disrupted in certain lifestyle-related diseases. However, it remains unclear whether type 2 diabetes resul
Autor:
Juliana Maria Navia-Pelaez, Gianne P. Campos-Mota, Jessica Cristina Araujo-Souza, Luciano S. A. Capettini, Nikolaos Stergiopulos
Publikováno v:
Atherosclerosis. 258:108-118
Background and aims: Lysophosphatidylcholine (LPC) - a main component of oxidized LDL -is involved in endothelial dysfunction that precedes atherosclerosis, with an increased superoxide anions and a reduced NO production via endothelial NO synthase (
Autor:
Chun Yang, Caroline A. Lee, Bradley Kerr, Shakti Valdez, Zancong Shen, David M. Wilson, Michael Gillen
Publikováno v:
Clinical Pharmacology in Drug Development. 6:363-376
Lesinurad is a selective uric acid reabsorption inhibitor approved for the treatment of hyperuricemia associated with gout in combination with xanthine oxidase inhibitors. In vitro assays indicate that lesinurad is an inducer of CYPs in the order CYP