Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Irene M. Ghobrial"'
Autor:
Philippe Armand, Damian R. Handisides, Irene M. Ghobrial, Jacalyn Rosenblatt, Kenneth C. Anderson, Jacquelyn Hedlund, Paul G. Richardson, Henry Dumke, Bradley Rivotto, Stacey Chuma, Robert L. Schlossman, Kenneth H. Shain, Stew Kroll, Patrick Henrick, Chia Jen Liu, Noopur Raje, Michael Gary Martin, Alexandra Savell, Andrew Yee, Craig Reynolds, Kalvis Hornburg, Laura Stampleman, Jacob P. Laubach, Ira Zackon
Publikováno v:
Clinical Cancer Research. 25:478-486
Purpose: The presence of hypoxia in the diseased bone marrow presents a new therapeutic target for multiple myeloma. Evofosfamide (formerly TH-302) is a 2-nitroimidazole prodrug of the DNA alkylator, bromo-isophosphoramide mustard, which is selective
Autor:
Ofer Shpilberg, Irene M. Ghobrial, Moshe Mittelman, Ashraf Badros, Ivan Spicka, Arnon Nagler, Kenneth C. Anderson, Richard Leblanc, Jacob P. Laubach, Kihyun Kim, Teru Hideshima, Peter Sportelli, Paul Blake, Paul G. Richardson, Moshe E. Gatt, Merav Leiba, Sung-Soo Yoon, Michael Chen, Kathleen Colson, Roman Hájek, Hakan Kaya, Joaquin Martinez-Lopez, Parameswaran Hari, Dina Ben-Yehuda
Publikováno v:
EJHaem. 1(1)
Perifosine, an investigational, oral, synthetic alkylphospholipid, inhibits signal transduction pathways of relevance in multiple myeloma (MM) including PI3K/Akt. Perifosine demonstrated anti-MM activity in preclinical studies and encouraging early-p
Autor:
Omar Nadeem, Alexandra Distaso, Kelly Masone, Sarah Patches, Vaishali Sanchorawala, Paul G. Richardson, Giada Bianchi, Trevor J. Bayliss, Jacob P. Laubach, Isabella Hou, Robert A. Redd, Mary McKenney, Kenneth C. Anderson, Irene M. Ghobrial, Lindsay Issokson, Nikhil C. Munshi, Anna Barrell, Clifton C. Mo, Virginia Dalton, Peter Barth, Adam S. Sperling, Leyla Shune
Publikováno v:
Blood. 138:1650-1650
Introduction: Ixazomib is an oral proteasome inhibitor (PI) that is currently approved to be administered once weekly in combination with lenalidomide (LEN) and dexamethasone in RRMM (Moreau et al N Eng J Med 2016; 374:1621-1634). As most patients ar
Autor:
Sandra Kanan, Lian Xu, Christopher J. Patterson, Christina K. Tripsas, Irene M. Ghobrial, Jorge J. Castillo, Zachary R. Hunter, Patricia Sheehy, Barry Turnbull, Xia Liu, Kirsten Meid, Diane Warren, Stacey Chuma, Steven P. Treon, Guang Yang, Yang Cao
Publikováno v:
Blood. 124:503-510
Bortezomib frequently produces severe treatment-related peripheral neuropathy (PN) in Waldenström's macroglobulinemia (WM). Carfilzomib is a neuropathy-sparing proteasome inhibitor. We examined carfilzomib, rituximab, and dexamethasone (CaRD) in sym
Autor:
Peter Sabbatini, Stacey Chuma, Alexandra Savell, Patrick Henrick, Irene M. Ghobrial, Kenneth C. Anderson, Jacob P. Laubach, Chia Jen Liu, Kaitlen Reyes, Raymond P. Perez, Paul G. Richardson, Pamela S. Becker, Kalvis Hornburg
Publikováno v:
Blood. 132:3263-3263
Background : CXCR4 is a chemokine receptor over-expressed on > 75% of cancers, including malignant plasma cells. Ulocuplumab (BMS- 936564) is a first in class, fully human IgG4 monoclonal anti-CXCR4 antibody which inhibits the binding of CXCR4 to CXC
Autor:
L. Gardner, Amrita Krishnan, Robert L. Schlossman, Jeff Allerton, Jacob P. Laubach, David Irwin, Sagar Lonial, Kathleen Colson, John J. Densmore, Noopur Raje, Peter Sportelli, Jeff Zonder, Enrique Poradosu, Jeff Wolf, Andrzej Jakubowiak, Kenneth C. Anderson, Michael Bar, Paul G. Richardson, Irene M. Ghobrial, Teru Hideshima, Thomas Martin, Nikhil C. Munshi
Publikováno v:
Journal of Clinical Oncology. 29:4243-4249
Purpose Novel agents have improved patient outcome in relapsed or relapsed/refractory multiple myeloma (MM). Preclinical data show that the novel signal transduction modulator, perifosine, enhances the cytotoxicity of dexamethasone and bortezomib. Cl
Autor:
Pierfrancesco Tassone, Merav Leiba, Kenneth C. Anderson, Mariateresa Fulciniti, Klaus Podar, Xian Feng Li, Matthew Rumizen, Dharminder Chauhan, Nikhil C. Munshi, Peter Burger, Aileen Morrison, Yu-Tzu Tai, Teru Hideshima, Weihua Song, Irene M. Ghobrial, Paul G. Richardson
Publikováno v:
Blood. 110:1656-1663
Activation of the extracellular signal-regulated kinase1/2 (ERK1/2) signaling cascade mediates human multiple myeloma (MM) growth and survival triggered by cytokines and adhesion to bone marrow stromal cells (BMSCs). Here, we examined the effect of A
Autor:
Nikhil C. Munshi, Robert J. Soiffer, Mary Doyle, Gary Bradwin, Irene M. Ghobrial, Constantine S. Mitsiades, Fangxin Hong, Edie Weller, Leslie Lockridge, Diane Warren, Brendan Connell, Paul G. Richardson, Kenneth C. Anderson, Deanna Tocco, Rachel P. Rosovsky, Robert L. Schlossman
Publikováno v:
British journal of haematology. 160(3)
In this prospective study of patients with relapsed or relapsed and refractory multiple myeloma (MM) treated with lenalidomide and dexamethasone, relationships between markers of endothelial stress and drug administration and incidence of venous thro
Autor:
Xavier Leleu, Domenico Russo, Steven P. Treon, Bryan Ciccarelli, Lian Xu, Xiaoying Jia, Irene M. Ghobrial, Aldo M. Roccaro, Christopher J. Patterson, Anne-Sophie Moreau, Kenneth C. Anderson, Hai T. Ngo, Evdoxia Hatjiharissi, Antonio Sacco, Franco Dammacco, Angelo Vacca
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 14(6)
Purpose: Resveratrol (3,4',5-tri-hydroxy-trans-stilbene) is an antioxidant constituent of a wide variety of plant species including grapes. It has gained considerable attention because of its anticancer properties, as shown in solid and hematologic m
Autor:
Jacalyn Rosenblatt, Michael Gary Martin, Robert L. Schlossman, Philippe Armand, Kenneth C. Anderson, Stew Kroll, Rebecca Liguori, Craig H. Reynolds, Stacey Chuma, Damian Handisides, J. A. Hedlund, Paul G. Richardson, Noopur Raje, Erica N Boswell, Irene M. Ghobrial, Ira Zackon, Kenneth H. Shain, Andrew Yee, Laura Stampleman, Jacob P. Laubach
Publikováno v:
Journal of Clinical Oncology. 33:8579-8579
8579 Background: The presence of hypoxia in the diseased bone marrow presents a new therapeutic target for multiple myeloma (MM) (Colla, Leukemia 2010). Evofosfamide (EVO; formerly TH-302) is a nov...