Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Stephen Lee"'
Autor:
Jun Yang, Kin Sing Stephen Lee, Bruce D. Hammock, Sean D. Kodani, Christophe Morisseau, Shizuo G. Kamita
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4993, p 4993 (2021)
International journal of molecular sciences, vol 22, iss 9
International Journal of Molecular Sciences
Volume 22
Issue 9
International journal of molecular sciences, vol 22, iss 9
International Journal of Molecular Sciences
Volume 22
Issue 9
Epoxy-fatty acids (EpFAs) are endogenous lipid mediators that have a large breadth of biological activities, including the regulation of blood pressure, inflammation, angiogenesis, and pain perception. For the past 20 years, soluble epoxide hydrolase
Autor:
Benjamin Kessler, Seyedehelham Pourmand, Devon Dattmore, Jamie Alan, Morteza Sarparastzardroudi, Fan Zhang, Kin Sing Stephen Lee
Publikováno v:
The FASEB Journal. 35
Publikováno v:
Nutrients, Vol 12, Iss 3523, p 3523 (2020)
Nutrients
Nutrients
Due to the aging population in the world, neurodegenerative diseases have become a serious public health issue that greatly impacts patients’ quality of life and adds a huge economic burden. Even after decades of research, there is no effective cur
Autor:
Bruce D. Hammock, Sung-Hee Hwang, Kin Sing Stephen Lee, Karen Wagner, Jun Yang, Jen C. Ng, Christophe Morisseau
Publikováno v:
Bioorg Med Chem
Bioorganic & medicinal chemistry, vol 28, iss 22
Bioorganic & medicinal chemistry, vol 28, iss 22
Soluble epoxide hydrolase (sEH), a novel therapeutic target for neuropathic pain, is a largely cytosolic enzyme that degrades epoxy-fatty acids (EpFAs), an important class of lipid signaling molecules. Many inhibitors of sEH have been reported, and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e78f87d163f7634b0173f449cbace7
https://europepmc.org/articles/PMC7914304/
https://europepmc.org/articles/PMC7914304/
Publikováno v:
J Pharmacol Exp Ther
The Journal of pharmacology and experimental therapeutics, vol 374, iss 1
The Journal of pharmacology and experimental therapeutics, vol 374, iss 1
1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea (TPPU) and 1-(4-trifluoro-methoxy-phenyl)-3-(1-cyclopropanecarbonyl-piperidin-4-yl)-urea (TCPU) are potent inhibitors of soluble epoxide hydrolase (sEH) that have much better efficacy i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a34a8ccea1c33ecf380feccff869971
https://europepmc.org/articles/PMC7318792/
https://europepmc.org/articles/PMC7318792/
Autor:
Christophe Morisseau, Briana Hamamoto, Vengai Mavangira, Bruce D. Hammock, Todd R. Harris, Diyala S. Shihadih, Alonso G. P. Guedes, Sean D. Kodani, Sung Hee Hwang, Kin Sing Stephen Lee
Publikováno v:
Frontiers in Veterinary Science
Frontiers in Veterinary Science, Vol 7 (2020)
Frontiers in Veterinary Science, Vol 7 (2020)
The veterinary pharmacopeia available to treat pain and inflammation is limited in number, target of action and efficacy. Inhibitors of soluble epoxide hydrolase (sEH) are a new class of anti-inflammatory, pro-resolving and analgesic drugs being test
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO1-8
Publikováno v:
Composites Communications. 27:100864
In the present work, dry fibre placement (DFP) of co-polyamide based carbon fibre spreadtow bindered tape for fabrication of thermoplastic acrylic resin composites was explored. The DFP followed by vacuum assisted liquid resin infusion (LRI) is expec
Autor:
Trajen Head, Mark L. Gonzalgo, Timothy E. Audas, Miling Wang, Arun Malhotra, Laura Trinkle-Mulcahy, Caroline Gardiner, J.J. David Ho, J. Kishan Perera, Danielle E. Audas, Clay A. Bennett, Merce Jorda, Oleksandr N. Kryvenko, Sylvia Daunert, Stephen Lee, Mireille Khacho, Mathieu D. Jacob
Publikováno v:
Developmental Cell. 39:155-168
The amyloid state of protein organization is typically associated with debilitating human neuropathies and is seldom observed in physiology. Here, we uncover a systemic program that leverages the amyloidogenic propensity of proteins to regulate cell
Autor:
Matthew L. Edin, Kin Sing Stephen Lee, John Paul SanGiovanni, Zhongxiao Wang, Darryl C. Zeldin, Elizabeth P Moran, Nicholas Saba, Ann Hellström, Chi-Hsiu Liu, Thomas Fredrick, Bruce D. Hammock, Steven Meng, Fred B. Lih, Zhongjie Fu, Peyton Morss, Samuel B. Burnim, Yan Gong, Zhuo Shao, Lois E.H. Smith
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology, vol 36, iss 9
Objective— Pathological ocular neovascularization is a major cause of blindness. Increased dietary intake of ω-3 long-chain polyunsaturated fatty acids (LCPUFA) reduces retinal neovascularization and choroidal neovascularization (CNV), but ω-3 LC