Zobrazeno 1 - 10
of 180
pro vyhledávání: '"Majer A"'
Autor:
Pavel Majer, Rana Rais, Kathryn M. Lemberg, Ying Wu, Lukáš Tenora, Barbara S. Slusher, Sadakatali S Gori, Vijayabhaskar Veeravalli, Ranjeet Prasad Dash, Qi Sun, Arindom Pal, Jesse Alt, Joanna Marie H. Aguilar
Publikováno v:
Curr Drug Metab
Background: Metabolomic analyses from our group and others have shown that tumors treated with glutamine antagonists (GA) exhibit robust accumulation of formylglycinamide ribonucleotide (FGAR), an intermediate in the de novo purine synthesis pathway.
Autor:
Dan Su, Kyle M. Lancaster, Sean H. Majer, Rachael E. Coleman, Michael K. Fenwick, Brian R. Crane, Siddarth Chandrasekaran, Jack H. Freed, Boris Dzikovski, Hening Lin, Yugang Zhang
Publikováno v:
Journal of the American Chemical Society
All radical S-adenosylmethionine (radical-SAM) enzymes, including the noncanonical radical-SAM enzyme diphthamide biosynthetic enzyme Dph1–Dph2, require at least one [4Fe–4S](Cys)3 cluster for activity. It is well-known in the radical-SAM enzyme
Autor:
Jiří Brynda, Ullrich Jahn, Milan Potáček, Anna Hlavačková, Vlastimil Král, M. Kugler, Pavlína Řezáčová, Jiří Schimer, Milan Dejmek, Pavel Šácha, Jan Tykvart, Jan Konvalinka, Lukáš Tenora, Václav Navrátil, Jitka Zemanova, Pavel Majer
Publikováno v:
SLAS Discovery. 25:1026-1037
The DNA-linked inhibitor antibody assay (DIANA) has been recently validated for ultrasensitive enzyme detection and for quantitative evaluation of enzyme inhibitor potency. Here we present its adaptation for high-throughput screening of human carboni
Autor:
W. David Church, Dennis Wegener, Tim J. Wigle, Arne Brendes, Kevin Wayne Kuntz, Demet Aybar, Paul Chang, Melissa Vasbinder, Claudia Beck, Martin Prahm, Kerren Kalai Swinger, Laurie B. Schenkel, Christina R. Majer
Publikováno v:
Slas Discovery
Mono(ADP-ribosylation) (MARylation) and poly(ADP-ribosylation) (PARylation) are posttranslational modifications found on multiple amino acids. There are 12 enzymatically active mono(ADP-ribose) polymerase (monoPARP) enzymes and 4 enzymatically active
Autor:
Martin Dračínský, Aleš Machara, Milan Kožíšek, Pavel Majer, Robert Reiberger, Jiří Brynda, Václav Zima, Kateřina Radilová, Michal Kráľ, Jan Konvalinka
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7735, p 7735 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 14
International Journal of Molecular Sciences
Volume 22
Issue 14
The part of the influenza polymerase PA subunit featuring endonuclease activity is a target for anti-influenza therapies, including the FDA-approved drug Xofluza. A general feature of endonuclease inhibitors is their ability to chelate Mg2+ or Mn2+ i
Autor:
Tereza Ormsby, Pavel Majer, Natan Sidej, Jiří Brynda, Lenka Poštová Slavětínská, Adéla Šimková, Jana Beranová, Pavel Šácha, Jan Konvalinka
Publikováno v:
European journal of medicinal chemistry. 224
Peptidomimetic inhibitors of fibroblast activation protein (FAP) are regarded as promising tools for tumor targeting in vivo. Even though several peptidomimetic compounds with nanomolar potency have been described, broad chemical space for further mo
Publikováno v:
Chemical Science. 10:3756-3764
Ammonia oxidizing bacteria (AOB) use the cytotoxic, energetic molecule hydroxylamine (NH2OH) as a source of reducing equivalents for cellular respiration. Despite disproportionation or violent decomposition being typical outcomes of reactions of NH2O
Autor:
Ivan Snajdr, Pavel Majer, Zsofia Kutil, Barbora Havlinova, Cyril Barinka, Zora Novakova, Martin Hadzima, David Rauh, Lubica Skultetyova, Marat Meleshin, Mike Schutkowski, Jana Mikešová, Jiri Pavlicek, Petra Baranova
Publikováno v:
The FASEB Journal. 33:4035-4045
Histone deacetylase 6 (HDAC6) is a multidomain cytosolic hydrolase acting mostly on nonhistone protein substrates. Investigations of the substrate specificity of HDAC6 are confounded by the presence of 2 catalytically active deacetylase domains (DD1
Publikováno v:
Journal of Geochemical Exploration. 191:1-21
Mining in the former Novator coal and uranium mine ceased in 1957 and a part of the wastes underwent spontaneous ignition in 1959–1970. Since the 1970s, the waste heap has been exposed to continuous weathering. The objective of this study was to as
Autor:
Jakub Majer, Łukasz Bojarski, Katarzyna Bazydlo, Filip Stefaniak, Maciej Wieczorek, Damian Smuga, Rafał Moszczyński-Pętkowski, Malgorzata Borkowska, Sylwia Janowska, Krzysztof Dubiel, Mikołaj Matłoka
Publikováno v:
European Journal of Medicinal Chemistry. 155:96-116
New compounds containing [1,2,4]triazolo [1,5-a]pyridine (I), pyrazolo [1,5-a]pyridine (II), 1H-1,3-benzodiazole (III) and imidazo [1,2-a]pyrimidine (IV) backbones were designed and synthesized for PDE10A interaction. Among these compounds, 1H-1,3-be