Zobrazeno 1 - 3
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pro vyhledávání: '"Hiromasa, Yoshioka"'
Autor:
Ngee Kiat Chua, Yuichi Hashimoto, Kenji Ohgane, Hudson W. Coates, Andrew J. Brown, Hiromasa Yoshioka
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance Cholesterol is an essential component of cell membranes and a precursor for steroid hormones and bile acids. Squalene monooxygenase (SM) is a rate-limiting enzyme in the cholesterol biosynthetic pathway and has been demonstrated to be po
Publikováno v:
Bioorganicmedicinal chemistry. 28(3)
HMG-CoA reductase (HMGCR) is the rate-limiting enzyme in the cholesterol biosynthetic pathway, and is the target of cholesterol-lowering drugs, statins. Previous studies have demonstrated that the enzyme activity is regulated by sterol-induced degrad
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115576
HMG-CoA reductase (HMGCR) is a rate-limiting enzyme in the cholesterol biosynthetic pathway, and its catalytic domain is the well-known target of cholesterol-lowering drugs, statins. HMGCR is subject to layers of negative feedback loops; excess chole