Zobrazeno 1 - 10
of 824
pro vyhledávání: ''
Autor:
Shouta M.M. Nakayama, Yusuke K. Kawai, Yoshinori Ikenaka, Marumi Ohno, Kensuke P. Watanabe, Mayumi Ishizuka, Yoshihiro Nishiyama
Publikováno v:
The Journal of Veterinary Medical Science
Rat cytochrome P450 (CYP) exhibits inter-strain differences, but their analysis has been scattered across studies under different conditions. To identify these strain differences in CYP more comprehensively, mRNA expression, protein expression and me
Autor:
Braulio Rojas, Mario Herrera-Marschitz, David Vásquez, Diego Lagos, Mario Rivera-Meza, María Elena Quintanilla, Yedy Israel
Publikováno v:
Neuropharmacology. 146
A number of pre-clinical studies have shown that brain-generated acetaldehyde, the first metabolite of ethanol, exerts reinforcing effects that promote the acquisition of ethanol intake, while chronic intake maintenance appears to be mediated by alco
Autor:
Jørg Mørland, Berit Mørland
Publikováno v:
Acta Pharmacologica et Toxicologica. 50:221-224
Rats were fed an all liquid diet for 7–8 weeks. One group received 35% of the calories as ethanol while the other group was pair-fed carbohydrates. Peritoneal macrophages prepared from ethanol treated rats had lower phagocytosis via the Fc-receptor
Autor:
Ronald R. Scheline, Anna Walde
Publikováno v:
Acta Pharmacologica et Toxicologica. 53:57-63
The metabolism of p-tert.-butyltoluene (TBT) was studied in the rat and guinea pig. Both the methyl and the tert.-butyl group were oxidized to alcohol and carboxylic acid derivatives in these species. The major urinary metabolites in rats were p-tert
Publikováno v:
Acta Pharmacologica et Toxicologica. 53:88-91
The effect of manganese on free polysomal protein synthesis of immature rat brain (3 weeks old) has been determined after 1, 2, 3, and 4 weeks of daily intake of 55 micrograms manganese/ml of drinking water. The protein synthesis was inhibited up to
Autor:
Kaija Pyykkö
Publikováno v:
Acta Pharmacologica et Toxicologica. 53:401-409
In the liver microsomes of toluene-treated and control Sprague-Dawley rats (n=148, males and females aged 13–93 days), the contents of cytochrome P-450 and b5 and the activities of NADPH – cytochrome c reductase and four monooxygenases were studi
Autor:
Lucy Rényi
Publikováno v:
Acta Pharmacologica et Toxicologica. 59:298-302
The effects of the depletion of 5-hydroxytryptamine (5-HT) in the rat brain upon the 5-HT behavioural syndrome (ejaculatory response, abduction of hind-limbs, forepaw treading, and Straub tail) induced by 5-methoxy-N,N-dimethyltryptamine (1 mg/kg int
Publikováno v:
Acta Pharmacologica et Toxicologica. 59:425-429
The experiments were carried out on Wistar rats. The animals were divided into five groups: Group 1: control group; Group 2: the animals received a single intrarenal dose of nickel subsulfide (Ni3S2) in saline; Group 3: the animals receiving a single
Autor:
Jin-Ju Jeong, Jae-Hun Shim, Young-Tae Ahn, Chul-Sung Huh, Sin-Hyeog Im, Dong-Hyun Kim, Jae-Yeon Woo, Myung Joo Han
Publikováno v:
International immunopharmacology. 26(2)
To investigate the anti-inflammatory effect of probiotics, we orally administered IRT5 (1×10(9)CFU/rat) for 8 weeks to aged (16 months-old) Fischer 344 rats, and measured parameters of colitis. The expression levels of the inflammatory markers' indu
Autor:
Ming-Qiang Zheng, Ming-Wei Wang, Hancheng Cai, Duanzhi Yin, Gucai Li, Yongxian Wang, Dengfeng Cheng, Shiqiang Li
Publikováno v:
Chemical Biology & Drug Design. 68:319-325
In an effort to develop a peptide-based radiopharmaceutical for the detection of tumors overexpressed vasoactive intestinal peptide receptors with positron emission tomography, we have prepared a novel [R(8,15,21), L17]-VIP peptide for 18F-labeling.