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Autor:
Claude Garret, Veronique Fardin
Publikováno v:
European Journal of Pharmacology. 201:231-234
The affinities of various substance P agonists and antagonists for nk 1 receptors in rat and guinea-pig tissues were compared. Striking species differences were observed. Both septide and [D-Pro 4 ,D-Trp 7,9 ]SP-(4–11) possessed much higher affinit
Publikováno v:
Biochemical Pharmacology. 42:263-269
The activities and distribution of monoamine oxidase (MAO) and semicarbazide-sensitive amine oxidase (SSAO) in solid breast tumour induced in the rat by treatment with 7,12-dimethylbenz(α)anthracene (DMBA) were studied. The mammary tumours were clas
Autor:
Keishi Abe, Colin I. Johnston, Minoru Yasujima, David J. Casley, Kaoru Yoshinaga, Masahiro Kohzuki, Frederick A.O. Mendelsohn, Siew Yeen Chai
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 18:509-515
1. The distribution of binding sites for [125I]-labelled endothelin-1 ([125I]-ET-1) and [125I]-labelled sarafotoxin S6B ([125I]-SRT) was visualized in rat tissues using in vitro autoradiography. 2. A high density of endothelin-1 (ET-1) binding was fo
Autor:
Jarmo S. Salonen
Publikováno v:
Pharmacology & Toxicology. 69:1-4
Hydroxylation and N-methylation of three potent alpha 2-adrenoceptor agonists detomidine, medetomidine and dexmedetomidine by rat brain, kidney, liver and lung were studied in vitro. NADPH-dependent hydroxylation of the 3'-methyl group was catalyzed
Publikováno v:
Biochemical Pharmacology. 41:2005-2009
We examined the effects of the in vivo administration of ethanol on lipolytic activities assayed in rat post-heparin heart effluents, that hydrolyse tri-, di- and monoacylglycerol. Properties of triacylglycerol lipase (TAGL) are typical of lipoprotei
Publikováno v:
Planta Medica. 57:208-211
Blood glucose and total lipid levels in rats with streptozotocin-induced diabetes were determined after intraperitoneal administration of a methanolic extract of Prunus davidiana Fr. stems and its main component, prunin (= naringenin 7-O-beta-D-gluco
Autor:
Z. Taghavi, P.P. Godfrey
Publikováno v:
Neuropharmacology. 30:417-422
Previous work has shown that excitatory amino acids inhibit agonist or depolarisation evoked formation of inositol phosphate in brain. In this paper, possible mechanisms by which this may be occurring have been investigated. The inhibition of carbach
Publikováno v:
European Journal of Pharmacology. 196:161-167
Dynorphin A-(l-13)-Tyr 14 Leu 15 -Phe 16 -Asn 17 -Gly 18 -Pro 19 (dynorphin Ia: a peptide derived from the structure of adrenal dynorphin I) was synthesized by the solid-phase procedure. The product was purified and compared with dynorphin A-(l–13)
Publikováno v:
Journal of Cardiovascular Pharmacology. 17:456-465
The specific neutral endopeptidase (NEP) inhibitor, SQ 29,072 (7-[2-(mercaptomethyl)-1-oxo-3-phenylpropyl]amino]heptanoic acid), was studied in conscious spontaneously hypertensive rats (SHRs) and in DOCA/salt hypertensive rats during inhibition of a
Publikováno v:
Experientia. 47:241-245
The relationship between the activity of protein kinase C (PKC) and muscle innervation was explored in the rat sternomastoid muscle (SM) from day 18 of gestation (E18) to adult age. Between E18 and birth, PKC activity rose 5-fold, and during the day