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Publikováno v:
Canadian Journal of Physiology and Pharmacology. 69:1561-1566
In this article, after a very brief review on ANF receptors, we report our study on the effects of small C-ANF receptor ligands in the rat. Two small ligands were synthesized: 2-napthoxyacetyl-isonipecotyl-rANF 11–15-NH2 (5 aa), containing 5 amino
Autor:
Keishi Abe, Colin I. Johnston, Minoru Yasujima, David J. Casley, Kaoru Yoshinaga, Masahiro Kohzuki, Frederick A.O. Mendelsohn, Siew Yeen Chai
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 18:509-515
1. The distribution of binding sites for [125I]-labelled endothelin-1 ([125I]-ET-1) and [125I]-labelled sarafotoxin S6B ([125I]-SRT) was visualized in rat tissues using in vitro autoradiography. 2. A high density of endothelin-1 (ET-1) binding was fo
Autor:
Francys C. Verdial, Kenneth R. Olson, Nini Skovgaard, Nathan L. Whitfield, Edward L. Kreimier
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology. 294(6)
Hydrogen sulfide (H2S) is rapidly emerging as a biologically significant signaling molecule. Studies published before 2000 report low or undetectable H2S (usually as total sulfide) levels in blood or plasma, whereas recent work has reported sulfide c
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 68:1581-1589
Reactive oxygen species alter pulmonary arterial vascular tone and cause changes in pulmonary vascular resistance. The objective of this investigation was to determine direct effects of oxygen radicals on the contractile properties of pulmonary arter
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 68:1385-1387
In the present study we analyzed the effect of spironolactone administration on hepatic and intestinal p-nitrophenol-UDP-glucuronyltransferase activity. We used microsomal preparations from male and female Wistar rats to establish whether or not this
Publikováno v:
Canadian journal of physiology and pharmacology. 73(4)
In this study the glucose responsiveness of isolated, overnight-cultured islets of obese LA/N-corpulent (cp/cp) rats was compared with glucose phosphorylating activity to determine whether changes in the function of glucokinase could be identified. I
Autor:
Per-Ove Sjöquist, Stefan L. Marklund
Publikováno v:
Cardiovascular research. 26(4)
Objective: The aim was to determine if endothelium associated extracellular superoxide dismutase type C (EC-SOD C) exerts any protective effect against cardiac damage induced by ischaemia and reperfusion. Methods: Langendorff perfused rat hearts were
Publikováno v:
Canadian journal of physiology and pharmacology. 68(4)
The role of iron-loaded transferrin in xanthine–xanthine oxidase (X–XO) induced cardiac injury in isolated perfused rat hearts was examined. X (2 mM) – XO (10 U/L) perfusion resulted in contractile failure, a rise in resting tension, an increas
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 22:S26-S27
Summary 1. Nerve growth factor (NGF) is a neurotrophic peptide for peripheral sympathetic nerves. Hypotrophy of sympathetic nerve ganglia and reduced content of neuropeptide Y were reported in genetically hypertensive (GH) rats. These facts led us to
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 62:244-247
Cholesterol ester hydrolase activity was measured in isolated rat hepatocytes and adipocytes. Administration of triiodothyronine to rats resulted in a specific and selective increase in lysosomal acid (pH 4.5) cholesterol ester hydrolase activity in