Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Stephen Lee"'
Autor:
Jun Yang, Kin Sing Stephen Lee, Bruce D. Hammock, Sean D. Kodani, Christophe Morisseau, Shizuo G. Kamita
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4993, p 4993 (2021)
International journal of molecular sciences, vol 22, iss 9
International Journal of Molecular Sciences
Volume 22
Issue 9
International journal of molecular sciences, vol 22, iss 9
International Journal of Molecular Sciences
Volume 22
Issue 9
Epoxy-fatty acids (EpFAs) are endogenous lipid mediators that have a large breadth of biological activities, including the regulation of blood pressure, inflammation, angiogenesis, and pain perception. For the past 20 years, soluble epoxide hydrolase
Publikováno v:
Nutrients, Vol 12, Iss 3523, p 3523 (2020)
Nutrients
Nutrients
Due to the aging population in the world, neurodegenerative diseases have become a serious public health issue that greatly impacts patients’ quality of life and adds a huge economic burden. Even after decades of research, there is no effective cur
Autor:
Bruce D. Hammock, Sung-Hee Hwang, Kin Sing Stephen Lee, Karen Wagner, Jun Yang, Jen C. Ng, Christophe Morisseau
Publikováno v:
Bioorg Med Chem
Bioorganic & medicinal chemistry, vol 28, iss 22
Bioorganic & medicinal chemistry, vol 28, iss 22
Soluble epoxide hydrolase (sEH), a novel therapeutic target for neuropathic pain, is a largely cytosolic enzyme that degrades epoxy-fatty acids (EpFAs), an important class of lipid signaling molecules. Many inhibitors of sEH have been reported, and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e78f87d163f7634b0173f449cbace7
https://europepmc.org/articles/PMC7914304/
https://europepmc.org/articles/PMC7914304/
Autor:
Matthew L. Edin, Kin Sing Stephen Lee, John Paul SanGiovanni, Zhongxiao Wang, Darryl C. Zeldin, Elizabeth P Moran, Nicholas Saba, Ann Hellström, Chi-Hsiu Liu, Thomas Fredrick, Bruce D. Hammock, Steven Meng, Fred B. Lih, Zhongjie Fu, Peyton Morss, Samuel B. Burnim, Yan Gong, Zhuo Shao, Lois E.H. Smith
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology, vol 36, iss 9
Objective— Pathological ocular neovascularization is a major cause of blindness. Increased dietary intake of ω-3 long-chain polyunsaturated fatty acids (LCPUFA) reduces retinal neovascularization and choroidal neovascularization (CNV), but ω-3 LC
Autor:
Weicang Wang, Zhenhua Liu, Weipeng Qi, Katherine Z. Sanidad, Elvira Sukamtoh, Yeonhwa Park, Jun Yang, Kin Sing Stephen Lee, Yoshiki Nimiya, Guodong Zhang
Many studies have shown that dietary intake of ω-3 polyunsaturated fatty acids (PUFAs) reduces the risks of colorectal cancer; however, the underlying mechanisms are not well understood. Here we used a LC-MS/MS-based lipidomics to explore the role o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee6a1167eae859eabd3f0f4dfd88f83
https://europepmc.org/articles/PMC6278818/
https://europepmc.org/articles/PMC6278818/
Autor:
Bruce D. Hammock, Kin Sing Stephen Lee, V. V. Burmistrov, Christophe Morisseau, Gennady M. Butov, Diyala S. Shihadih, Todd R. Harris
Publikováno v:
Bioorganic & medicinal chemistry letters, vol 24, iss 9
A series of inhibitors of the soluble epoxide hydrolase (sEH) containing two urea groups has been developed. Inhibition potency of the described compounds ranges from 2.0 μM to 0.4 nM. 1,6-(Hexamethylene)bis[(adamant-1-yl)urea] (3b) was found to be
Förster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase
Autor:
Jun Yang, Christophe Morisseau, Sung Hee Hwang, Kin Sing Stephen Lee, Bruce D. Hammock, Peng Wang
Publikováno v:
Analytical Biochemistry. 434:259-268
The soluble epoxide hydrolase (sEH), responsible for the hydrolysis of various fatty acid epoxides to their corresponding 1,2-diols, is becoming an attractive pharmaceutical target. These fatty acid epoxides, particularly epoxyeicosatrienoic acids (E
Autor:
Bruce D. Hammock, John D. Imig, Kin Sing Stephen Lee, Abdul H. Khan, Amit Sharma, Scott P. Levick
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 5, p 751 (2016)
International Journal of Molecular Sciences; Volume 17; Issue 5; Pages: 751
International journal of molecular sciences, vol 17, iss 5
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 17; Issue 5; Pages: 751
International journal of molecular sciences, vol 17, iss 5
International Journal of Molecular Sciences
Cytochrome P450 (CYP) monooxygenases epoxidize the omega-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid into novel epoxydocosapentaenoic acids (EDPs) that have multiple biological actions. The present study determined the ability of the mos
Autor:
Aaron T. Wecksler, Catherine Deng, Christophe Morisseau, Kin Sing Stephen Lee, Jun Yang, Bruce D. Hammock, Sean D. Kodani, Hua Dong
Publikováno v:
Journal of lipid research, vol 55, iss 6
Journal of Lipid Research, Vol 55, Iss 6, Pp 1131-1138 (2014)
Journal of Lipid Research, Vol 55, Iss 6, Pp 1131-1138 (2014)
Epoxy FAs (EpFAs) are important lipid mediators that are mainly metabolized by soluble epoxide hydrolase (sEH). Thus, sEH inhibition is a promising therapeutic target to treat numerous ailments. Several sEH polymorphisms result in amino acid substitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c41b365d2325678a100ab5cbc1a6a2a
https://escholarship.org/uc/item/1g43r4p6
https://escholarship.org/uc/item/1g43r4p6
Autor:
Stephen Lee, Steven Kossard
Publikováno v:
Journal of Cutaneous Pathology. 25:222-227
We report a 70-year-old woman who over a 7-year period developed a widespread violaceous, reticulate and striate eruption with a keratotic component in a clinical pattern previously described as keratosis lichenoides chronica. Multiple biopsies showe