Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Nakanishi A"'
Publikováno v:
ACS Macro Letters. 10:926-932
Redox-active molecules are promising anticancer compounds because cancer cells are vulnerable to oxidative stress. Anticancer drugs are often incorporated into synthetic polymers to improve water solubility, stability, and retention in the body. Most
Autor:
Mai Asano, Michiaki Fukui, Naoko Nakanishi, Masahide Hamaguchi, Emi Ushigome, Yoshitaka Hashimoto, Hiroshi Takakuwa, Takafumi Senmaru, Hanako Nakajima, Masahiro Yamazaki, Saori Majima, Takuro Okamura
Publikováno v:
Endocrine Journal. 68:421-428
Diabetic retinopathy (DR), one of the major complications of diabetes, can cause blindness and reduce quality of life. Dyslipidemia is reported to be associated with DR, whereas arachidonic acid may have a protective effect against DR. We aimed to in
Publikováno v:
Free Radical Biology and Medicine. 157:55-62
Chronic kidney disease (CKD) patients have a tremendously higher risk of developing cardiovascular disease (CVD) and infection than the non-CKD population, which could be caused by intertwining actions of hyperphosphatemia and CKD associated misdistr
Autor:
Satoshi Ninagawa, Taiki Saito, Hirokazu Yagi, Miho Nishio, Takahiro Anzai, Yukiko Kamiya, Mahito Nakanishi, Koichi Kato, Kazuhiro Aoki, Tadashi Satoh, Honda Rena, Yusaku Ohta, Kousuke Suzuki, Maho Yagi-Utsumi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
MCFD2 and ERGIC-53, which are the products of causative genes of combined factor V and factor VIII deficiency, form a cargo receptor complex responsible for intracellular transport of these coagulation factors in the early secretory pathway. In this
Autor:
Tsuyoshi Nakanishi, Miguel M. Santos, Mónica Lopes-Marques, Raquel Ruivo, Youhei Hiromori, Daisuke Matsumaru, S.B. Sainath, L. Filipe C. Castro, Ana Capitão, Inês Páscoa
Publikováno v:
The Science of the total environment. 797
Environmental chemicals have been reported to greatly disturb the endocrine and metabolic systems of multiple animal species. A recent example involves the exploitation of the nuclear receptor (NR) heterodimeric pair composed by PPAR/RXR (peroxisome
Autor:
Yutaro Saito, Kentaro Mochidome, Hiroshi Nonaka, Yoichi Takakusagi, Ichio Aoki, Satoru Nagatoishi, Kouhei Tsumoto, Tomoki Ota, Satoshi Kuno, Fuminori Sugihara, Shinsuke Sando, Yuki Nakanishi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature Communications
Serine hydroxymethyltransferase (SHMT) is an enzyme that catalyzes the reaction that converts serine to glycine. It plays an important role in one-carbon metabolism. Recently, SHMT has been shown to be associated with various diseases. Therefore, SHM
Autor:
Hiroki Nakanishi, Daisuke Yamane, Michinori Kohara, Haruka Imagawa, Ikuyo Ichi, Moe Matsumoto, Yuri Hayashi, Stanley M. Lemon
Publikováno v:
Cell Chem Biol
Summary The metabolic oxidative degradation of cellular lipids severely restricts replication of hepatitis C virus (HCV), a leading cause of chronic liver disease, but little is known about the factors regulating this process in infected cells. Here
Publikováno v:
Acta biomaterialia. 132
Mechanics of the extracellular matrix (ECM) exhibit changes during many biological events. During disease progression, such as cancer, matrix stiffening or softening occurs due to crosslinking of the collagen matrix or matrix degradation through cell
Autor:
Fumihiro Ishikawa, Kiyofumi Ninomiya, Katsuki Takashima, Toshio Morikawa, Mika Sakano, Eri Kinouchi, Shinsuke Marumoto, Isao Nakanishi, Shinya Nakamura, Genzoh Tanabe
Publikováno v:
Bioorganicmedicinal chemistry letters. 33
Four chain-extended analogs (12a–12d) and two related de-O-sulfonated analogs (13a and 13c) by introducing alkyl groups (a: R = C3H7, b R = C6H13, c: R = C8H17, d: R = C10H21) to the side chains of salacinol (1), a natural α-glucosidase inhibitor
Autor:
Mitsunori Ikeguchi, Kouhei Tsumoto, Sae Yoshimi, Masateru Ohta, Satomi Kori, Makoto Nakanishi, Toru Ekimoto, Pierre-Antoine Defossez, Kosuke Yamaguchi, Kyohei Arita, Atsuya Nishiyama, Satoru Nagatoishi, Yuki Shibahashi
Publikováno v:
Bioorganic & Medicinal Chemistry. 52:116500
The accumulation of epigenetic alterations is one of the major causes of tumorigenesis. Aberrant DNA methylation patterns cause genome instability and silencing of tumor suppressor genes in various types of tumors. Therefore, drugs that target DNA me