Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Sofia Lövestam"'
Autor:
Michel Goedert, Masato Hasegawa, Airi Tarutani, Takashi Ando, Sofia Lövestam, Tomoyasu Matsubara, Mari Yoshida, Taisuke Tomita, Manuel Schweighauser, Kazuko Hasegawa, Sjors H.W. Scheres, Shigeo Murayama
Publikováno v:
FEBS Open Bio, Vol 11, Iss 4, Pp 999-1013 (2021)
FEBS Open Bio
FEBS Open Bio
The propagation of conformational strains by templated seeding is central to the prion concept. Seeded assembly of α‐synuclein into filaments is believed to underlie the prion‐like spreading of protein inclusions in a number of human neurodegene
Autor:
Kazuko Hasegawa, Ruben Vidal, Abhay Kotecha, Kathy L. Newell, Masato Hasegawa, Yuko Saito, Melissa Huang, Bernardino Ghetti, Tammaryn Lashley, G.I. Hallinan, Airi Tarutani, Tamas Revesz, Shigeo Murayama, Michel Goedert, Sofia Lövestam, Holly J. Garringer, John C. van Swieten, Yang Yang, Manuel Schweighauser, Diana Arseni, Masayuki Miyazaki, Masaki Takao, Benjamin Falcon, Mari Yoshida, Gabor G. Kovacs, Sjors H.W. Scheres, Yang Shi, Alexey G. Murzin, Wenjuan Zhang
SummaryMany age-dependent neurodegenerative diseases, like Alzheimer’s and Parkinson’s, are characterised by abundant inclusions of amyloid filaments. Filamentous inclusions of the proteins tau, amyloid-β (Aβ), α-synuclein and TDP-43 are the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fdce1da12c85094ec5e9c1872cde49c
https://doi.org/10.1101/2021.11.09.467923
https://doi.org/10.1101/2021.11.09.467923
Autor:
Alexey G. Murzin, Wenjuan Zhang, Melissa Huang, Kathy L. Newell, Isabelle Lavenir, Ellen Gelpi, Bernardino Ghetti, Sofia Lövestam, Michel Goedert, Holly J. Garringer, Sew Y. Peak-Chew, Abhay Kotecha, Benjamin Falcon, Yang Yang, Jennifer A. Macdonald, Gabor G. Kovacs, Sjors H.W. Scheres, Manuel Schweighauser, Diana Arseni, Ruben Vidal
Publikováno v:
Science
Filament assembly of amyloid-β peptides ending at residue 42 (Aβ42) is a central event in Alzheimer’s disease. We report the cryo-EM structures of Aβ42 filaments from brain. Two structurally related S-shaped protofilament folds give rise to two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a48e57feff85f04c66cbb2d57cbd196
https://doi.org/10.1101/2021.10.19.464936
https://doi.org/10.1101/2021.10.19.464936