Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Robert Rottapel"'
Autor:
Mohamed A. Soliman, Gerald D. Gish, Monika Tucholska, Rick Bagshaw, Sasha A. Doodnauth, Marilyn S Hsiung, Melany J. Wagner, Robert Rottapel, Claus Jørgensen
Publikováno v:
J Biol Chem
Eph receptors are a family of receptor tyrosine kinases that control directional cell movement during various biological processes, including embryogenesis, neuronal pathfinding, and tumor formation. The biochemical pathways of Eph receptors are cont
Autor:
Yosuke Asano, Yuriko Yamamura, Yoshinori Matsumoto, Jose La Rose, Ni Luh Gede Yoni Komalasari, Fang He, Masakiyo Sakaguchi, Jun Wada, Robert Rottapel, Takayuki Katsuyama, Nahoko Tomonobu
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Autor:
Takayuki Katsuyama, Yoshinori Matsumoto, Jun Wada, Jose La Rose, Shigetomo Tsuji, Robert Rottapel, Fang He, Wang Ziyi, Yosuke Asano, Hiroshi Kamioka
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Scientific Reports
Scientific Reports
Bone is a highly dynamic organ that undergoes remodeling equally regulated by osteoblast-mediated bone formation and osteoclast-mediated bone resorption. To clarify the regulation of osteoblastogenesis, primary murine osteoblasts are required for an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e0d8d8269803ede86a5e82bcaf25bb
https://doi.org/10.21203/rs.3.rs-116977/v1
https://doi.org/10.21203/rs.3.rs-116977/v1
Autor:
Brett Larsen, Jamie Lee Fritz, Anne-Claude Gingras, Kyle E. Francis, Kevin R. Brown, Trevor G. Shepherd, Karen Colwill, Olga Collins, Parima Saxena, Yudith Ramos Valdes, Robert Rottapel, Adrian Buensuceso
Publikováno v:
Paediatrics Publications
Cancers
Volume 12
Issue 5
Cancers, Vol 12, Iss 1250, p 1250 (2020)
Cancers
Volume 12
Issue 5
Cancers, Vol 12, Iss 1250, p 1250 (2020)
Epithelial ovarian cancer (EOC) has a unique mode of metastasis, where cells shed from the primary tumour, form aggregates called spheroids to evade anoikis, spread through the peritoneal cavity, and adhere to secondary sites. We previously showed th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a3b9f0868105921da5d2f9fdf1f6fd
https://ir.lib.uwo.ca/paedpub/1480
https://ir.lib.uwo.ca/paedpub/1480
Autor:
Tadateru Nishikawa, Mitsuhiko Ikura, Zhenhao Fang, Nikolina Radulovich, Ming-Sound Tsao, María-José Sandí, Robert Rottapel, Teklab Gebregiworgis, Christopher B. Marshall
Publikováno v:
Journal of the American Chemical Society. 140:4473-4476
Small GTPases (sGTPases) are critical switch-like regulators that mediate several important cellular functions and are often mutated in human cancers. They are activated by guanine nucleotide exchange factors (GEFs), which specifically catalyze the e
Autor:
Ni Luh Gede Yoni Komalasari, Jun Wada, Yosuke Asano, Yuriko Yamamura, Masakiyo Sakaguchi, Fang He, Yoshinori Matsumoto, Robert Rottapel, Takayuki Katsuyama, Jose La Rose, Nahoko Tomonobu
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 11 (2021)
Frontiers in Oncology, Vol 11 (2021)
Activity of transcription factors is normally regulated through interaction with other transcription factors, chromatin remodeling proteins and transcriptional co-activators. In distinction to these well-established transcriptional controls of gene e
Autor:
Hisham Ibrahim, Myron I. Cybulsky, María José Sandí, Björn Petri, Jacob Rullo, Paul Kubes, Michael Glogauer, Jose La Rose, Noah Fine, Ioannis D. Dimitriou, Jack Haitsma, Robert Rottapel
Publikováno v:
The Journal of Cell Biology
Journal of Cell Biology, 215(1), 107-119. Rockefeller University Press
Fine, N, Dimitriou, I D, Rullo, J, Sandi, M J, Petri, B, Haitsma, J, Ibrahim, H, La Rose, J, Glogauer, M, Kubes, P, Cybulsky, M & Rottapel, R 2016, ' GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation ', Journal of Cell Biology, vol. 215, no. 1, pp. 107-119 . https://doi.org/10.1083/jcb.201603109
Journal of Cell Biology, 215(1), 107-119. Rockefeller University Press
Fine, N, Dimitriou, I D, Rullo, J, Sandi, M J, Petri, B, Haitsma, J, Ibrahim, H, La Rose, J, Glogauer, M, Kubes, P, Cybulsky, M & Rottapel, R 2016, ' GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation ', Journal of Cell Biology, vol. 215, no. 1, pp. 107-119 . https://doi.org/10.1083/jcb.201603109
In their work, Fine et al. demonstrate that GEF-H1 is required for the spreading and crawling of neutrophils in response to intravascular blood flow. They uncover a novel mechanism that couples shear stress with Rho-dependent migratory behavior of ne
Autor:
Robert Rottapel, Michael Glogauer, Jose La Rose, Noah Fine, Eric Gracey, Ioannis D. Dimitriou
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 205(12)
Gout is a painful arthritic inflammatory disease caused by buildup of monosodium urate (MSU) crystals in the joints. Colchicine, a microtubule-depolymerizing agent that is used in prophylaxis and treatment of acute gout flare, alleviates the painful
Autor:
Hidemi Kurihara, Mikihito Kajiya, Robert Rottapel, Collin Schlosser, Yasuyoshi Ueki, Ernst J Reichenberger, Tetsuya Yoshimoto, Mizuho Kittaka
Publikováno v:
J Bone Miner Res
Periodontitis is a bacterially induced chronic inflammatory condition of the oral cavity where tooth-supporting tissues including alveolar bone are destructed. Previously, we have shown that the adaptor protein SH3-domain binding protein 2 (SH3BP2) p
Publikováno v:
Cellular Immunology
Cellular Immunology, 2020, 353, pp.104133. ⟨10.1016/j.cellimm.2020.104133⟩
Cellular Immunology, Elsevier, 2020, 353, pp.104133. ⟨10.1016/j.cellimm.2020.104133⟩
Cellular Immunology, 2020, 353, pp.104133. ⟨10.1016/j.cellimm.2020.104133⟩
Cellular Immunology, Elsevier, 2020, 353, pp.104133. ⟨10.1016/j.cellimm.2020.104133⟩
The natural bioactive glycerophospholipid lysophosphatidic acid (LPA) binds to its cognate G protein-coupled receptors (GPCRs) on the cell surface to promote the activation of several transcription factors, including NF-κB. LPA-mediated activation o