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Akademický článek
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Autor:
Ffion Walters, Muhammad Munem Ali, Gregory Burwell, Sergiy Rozhko, Zari Tehrani, Ehsaneh Daghigh Ahmadi, Jon E. Evans, Hina Y. Abbasi, Ryan Bigham, Jacob John Mitchell, Olga Kazakova, Anitha Devadoss, Owen J. Guy
Publikováno v:
Nanomaterials, Vol 10, Iss 9, p 1808 (2020)
Affinity biosensors based on graphene field-effect transistor (GFET) or resistor designs require the utilization of graphene’s exceptional electrical properties. Therefore, it is critical when designing these sensors, that the electrical properties
Externí odkaz:
https://doaj.org/article/6337020eee974b389b970b64c9c94aeb
Publikováno v:
ChemPlusChem. 86:1297-1306
A discrete tetrachloride tetrahydrate cluster, [Cl4 (H2 O)4 ]4- , was obtained with a partially-fluorinated triaminocyclopropenium cation, [C3 (N(CH2 CF3 )2 )(NEt2 )(NPr2 )]+ . The cluster consists of a [Cl2 (H2 O)2 ]2- square with each Cl- coordinat
Assessment of the effects of Syk and BTK inhibitors on GPVI-mediated platelet signaling and function
Autor:
Tony J. Zheng, Elizabeth R Lofurno, Joseph J. Shatzel, Joseph E. Aslan, Alexander R. Melrose, Monica T. Hinds, Tia C L Kohs, Hari Hara Sudhan Lakshmanan, Kevin G. Phillips, Owen J. T. McCarty, Jiaqing Pang, Meghan E. Fallon, Anh T. P. Ngo
Publikováno v:
Am J Physiol Cell Physiol
Spleen tyrosine kinase (Syk) and Bruton’s tyrosine kinase (BTK) play critical roles in platelet physiology, facilitating intracellular immunoreceptor tyrosine-based activation motif (ITAM)-mediated signaling downstream of platelet glycoprotein VI (
Autor:
Jiaqing Pang, Andras Gruber, Cristina Puy, Owen J. T. McCarty, David Gailani, Erik I. Tucker, Florea Lupu, Stéphanie E. Reitsma, Christina U. Lorentz
Publikováno v:
J Immunol
Complement factor H (CFH) is the major inhibitor of the alternative pathway of the complement system and is structurally related to beta2-glycoprotein I, which itself is known to bind to ligands, including coagulation factor XI (FXI). We observed red
Autor:
Joseph J. Shatzel, Andras Gruber, Cristina Puy, Christina U. Lorentz, Vikram Raghunathan, Jiaqing Pang, David Gailani, Owen J. T. McCarty, Stéphanie E. Reitsma, Erik I. Tucker
Publikováno v:
Am J Physiol Cell Physiol
Factor XI (FXI) has been shown to bind platelets, but the functional significance of this observation remains unknown. Platelets are essential for hemostasis and play a critical role in thrombosis, whereas FXI is not essential for hemostasis but prom
Autor:
Imran Ahmad, Laura C. A. Galbraith, Gillian M. Mackay, Ernest Mui, Colin Nixon, Owen J. Sansom, Hing Y. Leung, David Sumpton, Ann Hedley, David P. Strachan
Publikováno v:
Oncogene
Peroxisome Proliferator-Activated Receptor Gamma (PPARG) is one of the three members of the PPAR family of transcription factors. Besides its roles in adipocyte differentiation and lipid metabolism, we recently demonstrated an association between PPA
Autor:
Larry S. Sherman, Joseph J. Shatzel, Peter Pham, Iván Parra-Izquierdo, Kelley Jordan, Owen J. T. McCarty, Norah G. Verbout, Andras Gruber
Publikováno v:
Metab Brain Dis
The coagulation cascade and immune system are intricately linked, highly regulated and respond cooperatively in response to injury and infection. Increasingly, evidence of hyper-coagulation has been associated with autoimmune disorders, including mul
Autor:
Bin Yan, Chelsea J. Nikula, Owen J. Sansom, Spencer A. Thomas, Teresa Murta, Rory T. Steven, Alex Dexter, Andrew D. Campbell, Efstathios A Elia, Richard J. A. Goodwin, Zoltan Takats, Josephine Bunch, Lucas B. Zeiger
Publikováno v:
Analytical Chemistry. 93:2309-2316
Mass spectrometry imaging can produce large amounts of complex spectral and spatial data. Such data sets are often analyzed with unsupervised machine learning approaches, which aim at reducing their complexity and facilitating their interpretation. H