Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mauricio J. Reginato"'
Autor:
Dimpi Mukhopadhyay, Neha M. Akella, Zachary A. Bacigalupa, Mauricio J. Reginato, Lorela Ciraku, Valerie L. Sodi, Ayonika Mukherjee, Giang Le Minh
Publikováno v:
Mol Cancer Res
Breast tumors are heterogeneous and composed of different subpopulation of cells, each with dynamic roles that can change with stage, site, and microenvironment. Cellular heterogeneity is, in part, due to cancer stem–like cells (CSC) that share pro
Publikováno v:
Cell Signal
O-GlcNAcylation is a post-translational modification occurring on serine/threonine residues of nuclear and cytoplasmic proteins, mediated by the enzymes OGT and OGA which catalyze the addition or removal of the UDP-GlcNAc moieties, respectively. Stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83a24cf855f891788955d5d090a95102
https://europepmc.org/articles/PMC8712408/
https://europepmc.org/articles/PMC8712408/
Autor:
Rusia H. Lee, Lorela Ciraku, Joshua G. Jackson, Sophie Trefely, Rebecca A. Moeller, Luca D'Agostino, Christina M. Ferrer, Michael D. Smith, Wiktoria A. Gocal, Jing Ju, Christos D. Katsetos, Nathaniel W. Snyder, Mary T. Doan, Wenyin Shi, Zachary A. Bacigalupa, Mauricio J. Reginato
Glioblastomas (GBMs) preferentially generate acetyl-CoA from acetate as a fuel source to promote tumor growth. O-GlcNAcylation has been shown to be elevated by increasing O-GlcNAc transferase (OGT) in many cancers and reduced O-GlcNAcylation can bloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb9715be7425091d0452b0335211d562
https://doi.org/10.1101/2021.05.10.443157
https://doi.org/10.1101/2021.05.10.443157
Autor:
Emmanuelle Nicolas, Lauren S. Fink, Mauricio J. Reginato, Alexander Strigun, Alexander Beatty, Timothy P. Moran, Kathy Q. Cai, Jeffrey R. Peterson, Ulrike Rennefahrt, Tanu Singh, Christina M. Ferrer, Erik Peter
Publikováno v:
Molecular Cancer Therapeutics. 17:264-275
Cancer cells can exhibit altered dependency on specific metabolic pathways and targeting these dependencies is a promising therapeutic strategy. Triple-negative breast cancer (TNBC) is an aggressive and genomically heterogeneous subset of breast canc
Autor:
Nathaniel W. Snyder, Rebecca A. Moeller, Christos D. Katsetos, Christina M. Ferrer, Wenyin Shi, Lorela Ciraku, Luca D'Agostino, Sophie Trefely, Zachary A. Bacigalupa, Mauricio J. Reginato, Rusia H. Lee, Jing Ju
Publikováno v:
Cancer Research. 81:86-86
Cancer cells alter their metabolism to increase cell growth. A subset of the glucose taken up is shunted into the hexosamine biosynthetic pathway where it is used to synthesize UDP-GlcNAc, a substrate of O-GlcNAc transferase (OGT), which modifies cyt
Publikováno v:
BMC Biology
BMC Biology, Vol 17, Iss 1, Pp 1-14 (2019)
BMC Biology, Vol 17, Iss 1, Pp 1-14 (2019)
Altered metabolism and deregulated cellular energetics are now considered a hallmark of all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor growth and act as substrates for the hexosamine biosynthetic pathwa
Autor:
S. RaElle Jackson, Andres J. Klein-Szanto, Kelly A. Whelan, Mauricio J. Reginato, Kristina S. Shahriari, Sarah A. Caldwell, Keneshia K. Haenssen
Publikováno v:
Journal of Cell Science. 123:1373-1382
ErbB2, a receptor tyrosine kinase highly expressed in many tumors, is known to inhibit apoptotic signals. Overexpression of ErbB2 causes anoikis resistance that contributes to luminal filling in three-dimensional mammary epithelial acinar structures
Autor:
Mauricio J. Reginato, Andrew W. Stadnyk, Christian Jobin, Joan S. Brugge, Robbie R. Joseph, Amanda Jackson, Sen Rong Yan, Kirill V. Rosen, Norman Allaire
Publikováno v:
Oncogene. 24:6482-6491
We reported earlier that IL-1beta, an NF-kappaB-regulated cytokine, was made by intestinal epithelial cells during detachment-induced apoptosis (anoikis) and that IL-1 was antiapoptotic for detached cells. Since surviving anoikis is a prerequisite fo
Autor:
Abelardo López-Rivas, Rosa Martín-Pérez, Mauricio J. Reginato, Joan Gil, Ana Cano-González, Daniel Iglesias-Serret, Rosario Yerbes, Carmen Palacios
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
HER2/Neu/ERBB2 is a receptor tyrosine kinase overexpressed in approximately 20% of human breast tumors. Truncated or mutant isoforms that show increased oncogenicity compared with the wild-type receptor are found in many breast tumors. Here, we repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d378d555be98e77ab501b4b8fd0155a1
http://hdl.handle.net/10261/123590
http://hdl.handle.net/10261/123590
Publikováno v:
Molecular and Cellular Biology. 17:1552-1561
Adipocyte differentiation is thought to involve sequential induction of the transcription factors C/EBPbeta, peroxisome proliferator-activated receptor gamma (PPARgamma), and C/EBPalpha. C/EBPalpha expression is both necessary and sufficient for adip