Zobrazeno 71 - 80
of 96
pro vyhledávání: '"Margery A. Connelly"'
Publikováno v:
Journal of Biological Chemistry. 274:41-47
Scavenger receptor BI (SR-BI) mediates the selective uptake of high density lipoprotein (HDL) cholesteryl ester (CE), a process by which HDL CE is taken into the cell without internalization and degradation of the HDL particle. The biochemical mechan
Publikováno v:
Genomics. 27:348-351
Helix-loop-helix proteins contain stretches of DNA that encode two amphipathic α-helices joined by a loop structure and are involved in protein dimerization and transcriptional regulation essential to a variety of cellular processes. CHUK, a newly d
Autor:
Bruce P. Damiano, Margery A. Connelly, Prasarn Manitpisitkul, Paul Rothenberg, Atalanta Ghosh, Elizabeth T. Leary, Keith T. Demarest, Troy C. Sarich, Dorota B. Schranz
Publikováno v:
International journal of clinical pharmacology and therapeutics. 50(8)
OBJECTIVE To assess and validate the application of a non-radioactive assay for cholesteryl ester transfer protein (CETP) activity in clinical samples. DESIGN AND METHODS In this Phase 0 study, CETP activity was measured following addition of the CET
Publikováno v:
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 60(9)
Endothelial lipase (EL), a member of the triglyceride lipase gene family, has been shown to be a key player in HDL metabolism. Northern blots revealed that EL was highly expressed in endothelium, thyroid, lung, placenta, liver, and testis. In liver a
Autor:
John C. O’Neill, Margery A. Connelly, Stephen C. Yabut, Diane K. Luci, Bruce E. Maryanoff, Mccomsey David F, Alan C. Gibbs
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(16)
Inhibitors of ketohexokinase (KHK) have potential for the treatment of diabetes and obesity. We have continued studies on a pyrimidinopyrimidine series of potent KHK inhibitors by exploring the 2-position substituent (R(3)) that interacts with Asp-27
Autor:
Eke G. Gruppen, Robin P. F. Dullaart, Margery A. Connelly, James D. Otvos, Stephan J. L. Bakker, Ineke J. Riphagen
Publikováno v:
PLoS ONE, 10(9):e0139057. PUBLIC LIBRARY SCIENCE
PLoS ONE, Vol 10, Iss 9, p e0139057 (2015)
PLoS ONE
PLoS ONE, Vol 10, Iss 9, p e0139057 (2015)
PLoS ONE
ObjectiveGlycA is a novel nuclear magnetic resonance spectroscopy-measured biomarker of systemic inflammation. We determined whether GlycA is associated with incident cardiovascular disease (CVD) in men and women, examined whether this association wi
Autor:
Troy C. Sarich, Frank Cools, Wai-man Cheung, David J. Gallacher, Edward C. Giardino, Cailin Chen, Henk van der Linde, Gee-Hong Kuo, Margery A. Connelly, Tom Jay Parry, Zhihong Huang, Keith T. Demarest, Bruce P. Damiano
Publikováno v:
Journal of cardiovascular pharmacology. 55(5)
OBJECTIVE Torcetrapib, a prototype cholesteryl ester transfer protein (CETP) inhibitor with potential for decreasing atherosclerotic disease, increased cardiovascular events in clinical trials. The identified hypertensive and aldosterone-elevating ac
Autor:
Gee-Hong Kuo, Margery A. Connelly, Bruce P. Damiano, Keith T. Demarest, Rano Thomas, Patricia Pelton, William V. Murray, Alan C. Gibbs
Publikováno v:
Journal of medicinal chemistry. 52(6)
With the goal of identifying a CETP inhibitor with high in vitro potency and optimal in vivo efficacy, a conformationally constrained molecule was designed based on the highly potent and flexible 13. The synthetic chemistry efforts led to the discove
Autor:
Margery A. Connelly
Publikováno v:
Molecular and cellular endocrinology. 300(1-2)
In adrenocortical cells, scavenger receptor class B, type I (SR-BI) is localized in specialized plasma membrane compartments, called microvillar channels, that retain high density lipoprotein particles (HDL) and are sites for the selective uptake of
Autor:
Deneys R. van der Westhuyzen, Bing Sun, Preetha Shridas, Margery A. Connelly, Nancy R. Webb, Boris B. Boyanovsky
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 12, Pp 2560-2570 (2007)
Modified forms of LDL, including oxidized low density lipoprotein (OxLDL), contribute to macrophage lipid accumulation in the vessel wall. Despite the pathophysiological importance of uptake pathways for OxLDL, the molecular details of OxLDL endocyto