Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Manal F. Abdelmalek"'
Autor:
Don C. Rockey, Andrew H. Beck, Murray B. Resnick, Nezam H. Afdhal, Michael Christopher Montalto, Oscar Carrasco-Zevallos, Catherine Jia, Zachary Goodman, Harsha Pokkalla, Mitchell L. Shiffman, Zahil Shanis, Ling Han, Jaime Bosch, Manal F. Abdelmalek, Arun J. Sanyal, Quang Huy Le, Chuhan Chung, Robert P. Myers, Ilan Wapinski, Stephen A. Harrison, Dinkar Juyal
Publikováno v:
Bosch, Jaime; Chung, Chuhan; Carrasco-Zevallos, Oscar M; Harrison, Stephen A; Abdelmalek, Manal F; Shiffman, Mitchell L; Rockey, Don C; Shanis, Zahil; Juyal, Dinkar; Pokkalla, Harsha; Le, Quang Huy; Resnick, Murray; Montalto, Michael; Beck, Andrew H; Wapinski, Ilan; Han, Ling; Jia, Catherine; Goodman, Zachary; Afdhal, Nezam; Myers, Robert P; ... (2021). A Machine Learning Approach to Liver Histological Evaluation Predicts Clinically Significant Portal Hypertension in NASH Cirrhosis. Hepatology, 74(6), pp. 3146-3160. Wiley 10.1002/hep.32087
BACKGROUND AND AIMS The hepatic venous pressure gradient (HVPG) is the standard for estimating portal pressure but requires expertise for interpretation. We hypothesized that HVPG could be extrapolated from liver histology using a machine learning (M
Autor:
Anna Mae Diehl, Ning-Ping Zhang, Ying Wang, Chen Yang, Xiuping Liu, Xue-Jing Liu, Wen‐Yue Dong, Chang Liu, Li Xie, Manal F. Abdelmalek, Jian Wu, Chenjian Gu, Kuo Du, Chen Niu
Publikováno v:
Liver Int
Background and aims Treatment of non-alcoholic steatohepatitis (NASH) is challenging, because suppressing fibrotic progression has not been achieved consistently by drug candidates currently in clinical trials. The aim of this study was to investigat
Autor:
Elizabeth K. Fletcher, Athan Kuliopulos, Nga Nguyen, Srijoy Guha, Andrew Shearer, Daniel H. Cox, James D. Baleja, Ying Wang, Manal F. Abdelmalek, Lidija Covic, Rajashree Rana
Publikováno v:
Molecular Metabolism, Vol 29, Iss, Pp 99-113 (2019)
Molecular Metabolism
Molecular Metabolism
Objective Increases in hepatic and plasma cholesterol occur in patients with nonalcoholic fatty liver disease (NAFLD), although the reason for this is not well understood. We investigated whether Protease-Activated Receptor 2 (PAR2) plays a role in c
Autor:
Jun Zhang, Roger J. Davis, Meng Li, Christopher Q. Chen, Anna Mae Diehl, Mariam Aghajan, Ying Wang, Robert Win Maw Min, Tin Aung Than, Sanda Win, Neil Kaplowitz, Yibu Chen, Manal F. Abdelmalek, Filbert W.M. Aung, Ayako Suzuki
Publikováno v:
Journal of Clinical Investigation. 129:5278-5293
SH3 domain–binding protein that preferentially associates with Btk (SAB) is an outer-membrane docking protein for JNK-mediated impairment of mitochondrial function. Deletion of Sab in hepatocytes inhibits sustained JNK activation and cell death. Th
Autor:
Manal F. Abdelmalek, Margery A. Connelly, Stephen J. Rossi, Mary E. Rinella, Angelo H. Paredes, Stephen A. Harrison, Lei Ling, James F. Trotter, Mark J. Jaros, Alex M. DePaoli
Publikováno v:
Journal of Hepatology. 70:735-744
NGM282, an engineered analogue of the gut hormone FGF19, improves hepatic steatosis and fibrosis biomarkers in patients with non-alcoholic steatohepatitis (NASH). However, NGM282 increases serum cholesterol levels by inhibiting CYP7A1, which encodes
Autor:
Andrea G. Nackley, Wolfgang Liedtke, Anna Mae Diehl, Huiping Ding, Andreas E. Kremer, Johannes Morstein, Ana E. López-Romero, Qian Zeng, Zilong Wang, Ru-Rong Ji, Qiaojuan Zhang, Yong Chen, Xin Zhang, Piotr Milkiewicz, Tony E. Reeves, Sara L. Morales-Lázaro, Jennifer Y. Zhang, Marcin Krawczyk, Tamara Rosenbaum, Mei-Chuan Ko, Frank Lammert, Andrey V. Bortsov, Manal F. Abdelmalek, Michele Yeo, Huanghe Yang, Carlene Moore, Ying-Ai Jin
Publikováno v:
Gastroenterology. 161(1)
Background & Aims Limited understanding of pruritus mechanisms in cholestatic liver diseases hinders development of antipruritic treatments. Previous studies implicated lysophosphatidic acid (LPA) as a potential mediator of cholestatic pruritus. Meth
Autor:
Kris V. Kowdley, Stephen A. Harrison, Manal F. Abdelmalek, Arun J. Sanyal, Zachary Goodman, Guruprasad P. Aithal, Star Seyedkazemi, Vincent Wai-Sun Wong, Rohit Loomba, Vlad Ratziu, Frank Tacke, Sven Francque, Laurent Fischer
Publikováno v:
Hepatology
Hepatology, Wiley-Blackwell, 2020, 72 (3), pp.892-905. ⟨10.1002/hep.31108⟩
Hepatology, Wiley-Blackwell, 2020, 72 (3), pp.892-905. ⟨10.1002/hep.31108⟩
International audience; Background and aims: Cenicriviroc (CVC) is a C-C chemokine receptors type 2 and 5 dual antagonist under evaluation for treating liver fibrosis in adults with nonalcoholic steatohepatitis (NASH). Year 1 primary analysis of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a6a62c5ef92690b2ab38f7860b50fdc
https://hal.sorbonne-universite.fr/hal-03213544
https://hal.sorbonne-universite.fr/hal-03213544
Autor:
Ying Wang, Cynthia D. Guy, Cynthia A. Moylan, Anna Mae Diehl, Catherine F. Howe, Manal F. Abdelmalek, Ricardo Henao, Kara Wegermann
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 5, Iss 4, Pp 608-617 (2021)
Hepatology Communications, Vol 5, Iss 4, Pp 608-617 (2021)
Identifying patients at higher risk for poor outcomes from nonalcoholic fatty liver disease (NAFLD) remains challenging. Metabolomics, the comprehensive measurement of small molecules in biological samples, has the potential to reveal novel noninvasi
Autor:
Naim Alkhouri, Andrea D. Coviello, Manal F. Abdelmalek, Eduardo B. Martins, Gerardo Rodriguez
Publikováno v:
Diabetes. 69
Introduction: In mice, C-C motif chemokine receptor (CCR)5 deletion protects against insulin resistance, hepatic steatosis, and glucose intolerance. We aimed to characterize the metabolic effects of cenicriviroc (CVC), a potent CCR2/5 inhibitor, in t
Autor:
Manal F. Abdelmalek, Richard T. Premont, Jeongeun Hyun, Mustafa R. Bashir, Cynthia A. Moylan, Kuo Du, Satish K. Chitneni, Ricardo Henao, Ayako Suzuki, Ying Wang, Anna Mae Diehl, Susanna Naggie
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 1-21 (2020)
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 1-21 (2020)
Background & Aims Nonalcoholic steatohepatitis (NASH) occurs in the context of aberrant metabolism. Glutaminolysis is required for metabolic reprograming of hepatic stellate cells (HSCs) and liver fibrogenesis in mice. However, it is unclear how chan