Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Manabu, Igarashi"'
Publikováno v:
PeerJ Physical Chemistry, Vol 3, p e19 (2021)
The substitution of Ile to Val at residue 117 (I117V) of neuraminidase (NA) reduces the susceptibility of the A/H5N1 influenza virus to oseltamivir (OTV). However, the molecular mechanism by which the I117V mutation affects the intermolecular interac
Autor:
Kengo Kawachi, Masayuki Shimojima, Miyuki Kimura, Shigeru Morikawa, Manabu Igarashi, Hideki Tani, Masayuki Saijo, Satoshi Taniguchi, Shuetsu Fukushi
Publikováno v:
Virology. 535:102-110
Severe fever with thrombocytopenia syndrome (SFTS) is an infectious disease with a high fatality rate, caused by SFTS virus (SFTSV). Because little is known about the nature of SFTSV, basic studies are required for the developments of vaccines and ef
Autor:
Taksoo Kim, Manabu Igarashi, Shizuka Hirose, Norikazu Isoda, Yoshihiro Sakoda, Loc Tan Huynh, Takahiro Hiono
Publikováno v:
Viruses, Vol 13, Iss 1672, p 1672 (2021)
Viruses
Volume 13
Issue 8
Viruses
Volume 13
Issue 8
The GPE− strain is a live attenuated vaccine for classical swine fever (CSF) developed in Japan. In the context of increasing attention for the differentiating infected from vaccinated animals (DIVA) concept, the achievement of CSF eradication with
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 12, p 2649 (2017)
Influenza A virus (IAV) matrix protein 2 (M2) is among the smallest bona fide, hence extensively studied, ion channel proteins. The M2 ion channel activity is not only essential for virus replication, but also involved in modulation of cellular homeo
Externí odkaz:
https://doaj.org/article/1e770c9ba383496cbd3a7db66493504d
Autor:
Masahiro Nakano, Yoko Fujita-Fujiharu, Yugo Tsunoda, Yukiko Muramoto, Kazuya Houri, Yukihiko Sugita, Yuki Takamatsu, Stephan Becker, Takeshi Noda, Manabu Igarashi
The nucleoprotein (NP) of Marburg virus (MARV), a close relative of Ebola virus (EBOV), encapsidates the single-stranded, negative-sense viral genomic RNA (vRNA) to form the helical NP-RNA complex. The NP-RNA complex serves as a scaffold for the asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::606a8beffef02b46d6ef634bd944bf17
https://doi.org/10.1101/2021.07.13.452116
https://doi.org/10.1101/2021.07.13.452116
Publikováno v:
PeerJ
PeerJ, Vol 9, p e11552 (2021)
PeerJ, Vol 9, p e11552 (2021)
Background Oseltamivir (OTV)-resistant influenza virus exhibits His-to-Tyr mutation at residue 274 (H274Y) in N1 neuraminidase (NA). However, the molecular mechanisms by which the H274Y mutation in NA reduces its binding affinity to OTV have not been
Autor:
Katherine M Fuller, Erica Ollmann Saphire, Manabu Igarashi, Ayato Takada, Diptiben V. Parekh, Jacob C. Milligan
Publikováno v:
The Journal of Infectious Diseases. 219:415-419
Ebola virus infection causes severe disease in humans and represents a global health threat. Candidates for immunotherapeutics and vaccines have shown promise in clinical trials, although they are ineffective against other members of the Ebolavirus g
Autor:
Yoshimi Tsuda, Jiro Arikawa, Kumiko Yoshimatsu, Manabu Igarashi, Fumiya Kozawa, Kisho Noda, Kenta Shimizu
Publikováno v:
Viruses
Volume 13
Issue 1
Viruses, Vol 13, Iss 33, p 33 (2021)
Volume 13
Issue 1
Viruses, Vol 13, Iss 33, p 33 (2021)
Severe fever with thrombocytopenia syndrome virus subclone B7 shows strong plaque formation and cytopathic effect induction compared with other subclones and the parental strain YG1. Compared to YG1 and the other subclones, only B7 possesses a single
Publikováno v:
Viruses
Volume 13
Issue 5
Viruses, Vol 13, Iss 913, p 913 (2021)
Volume 13
Issue 5
Viruses, Vol 13, Iss 913, p 913 (2021)
Filoviruses, including marburgviruses and ebolaviruses, have a single transmembrane glycoprotein (GP) that facilitates their entry into cells. During entry, GP needs to be cleaved by host proteases to expose the receptor-binding site that binds to th
Autor:
Xinhao Li, Kazuki Takeda, Dhoha Triki, Manabu Igarashi, Tsutomu Tanikawa, Kazuyuki D. Tanaka, Denis Fourches, Shouta M.M. Nakayama, Mayumi Ishizuka, Yoshinori Ikenaka
Publikováno v:
Pesticide biochemistry and physiology. 173:104774
Well-known 4-hydroxycoumarin derivatives, such as warfarin, act as inhibitors of the vitamin K epoxide reductase (VKOR) and are used as anticoagulants. Mutations of the VKOR enzyme can lead to resistance to those compounds. This has been a problem in