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of 4
pro vyhledávání: '"Lone H. Landsy"'
Autor:
Brian Lauritzen, Birgitte M. Viuff, Shari A. Price, Lone H. Landsy, Jens Lykkesfeldt, Hermann Pelzer, Lykke Boysen, James T. Raymond
Publikováno v:
Toxicologic Pathology. 48:570-585
Administration of human protein–based drugs to animals often leads to formation of antidrug antibodies (ADAs) that may form circulating immune complexes (CICs) with the dosed protein. Circulating immune complexes can activate and bind complement (c
Autor:
Birgitte M. Viuff, Anne Ejrnaes Sprinkel, Lykke Boysen, Brian Lauritzen, Lone H. Landsy, Jens Breinholt, Jens Lykkesfeldt
Publikováno v:
Biologicals. 60:42-48
Rapid and versatile methods are needed for evaluation of immunogenicity in early safety studies. The present work presents a generic, simple and easy to use sandwich enzyme-linked immunosorbent assay for quasi-quantitative measurement of circulating
Autor:
Brian Lauritzen, Lykke Boysen, Lone H. Landsy, Jens Lykkesfeldt, Birgitte M. Viuff, James T. Raymond, Shari A. Price
Publikováno v:
Journal of Immunotoxicology, Vol 16, Iss 1, Pp 191-200 (2019)
Boysen, L, Viuff, B M, Landsy, L H, Price, S A, Raymond, J T, Lykkesfeldt, J & Lauritzen, B 2019, ' Formation and glomerular deposition of immune complexes in mice administered bovine serum albumin : Evaluation of dose, frequency, and biomarkers ', Journal of Immunotoxicology, vol. 16, no. 1, pp. 191-200 . https://doi.org/10.1080/1547691X.2019.1680776
Boysen, L, Viuff, B M, Landsy, L H, Price, S A, Raymond, J T, Lykkesfeldt, J & Lauritzen, B 2019, ' Formation and glomerular deposition of immune complexes in mice administered bovine serum albumin : Evaluation of dose, frequency, and biomarkers ', Journal of Immunotoxicology, vol. 16, no. 1, pp. 191-200 . https://doi.org/10.1080/1547691X.2019.1680776
In preclinical toxicity studies, species-foreign proteins administered to animals frequently leads to formation of anti-drug antibodies (ADA). Such antibodies may form circulating immune complexes (CIC) with the administered protein. These CIC can ac
Publikováno v:
Journal of Immunotoxicology, Vol 16, Iss 1, Pp 82-86 (2019)
Boysen, L, Lauritzen, B, Viuff, B M, Lykkesfeldt, J & Landsy, L H 2019, ' An ELISA for detection of complement-bound circulating immune complexes in mice ', Journal of Immunotoxicology, vol. 16, no. 1, pp. 82-86 . https://doi.org/10.1080/1547691X.2019.1599471
Boysen, L, Lauritzen, B, Viuff, B M, Lykkesfeldt, J & Landsy, L H 2019, ' An ELISA for detection of complement-bound circulating immune complexes in mice ', Journal of Immunotoxicology, vol. 16, no. 1, pp. 82-86 . https://doi.org/10.1080/1547691X.2019.1599471
Measurements of complement-bound circulating immune complexes (cCICs) in pre-clinical studies may provide important information about the etiology of certain pathology findings suggestive of being immune complex mediated. This article describes the d