Zobrazeno 1 - 10
of 54
pro vyhledávání: '"L Kern"'
Publikováno v:
Catalysis Science & Technology. 10:2029-2039
Polyolefins are among the world's most widely produced and utilized classes of polymers, serving as synthetic alternatives to traditional materials such as wood, glass, and metal. While numerous prior research efforts have focused on the development
Publikováno v:
ACS Catalysis. 9:6223-6233
A combined computational and experimental study was undertaken to elucidate the mechanism of catalytic C2 + N1 aziridination supported by tetracarbene iron complexes. Three specific aspects of the ...
Autor:
Taraka Dale, Jeremy M. Bingen, Scott P. Hennelly, Christopher W. Johnson, Ramesh K. Jha, Niju Narayanan, Gregg T. Beckham, Naresh Pandey, Theresa L. Kern, Charlie E. M. Strauss
Publikováno v:
ACS Synthetic Biology. 8:775-786
Product inhibition is a frequent bottleneck in industrial enzymes, and testing mutations to alleviate product inhibition via traditional methods remains challenging as many variants need to be tested against multiple substrate and product concentrati
Autor:
Christopher W. Johnson, Payal Khanna, Jeremy M. Bingen, Taraka Dale, Gregg T. Beckham, Theresa L. Kern, Ramesh K. Jha, Daniel S. Trettel, Charlie E. M. Strauss
Publikováno v:
Metabolic Engineering Communications, Vol 6, Iss, Pp 33-38 (2018)
Robust fluorescence-based biosensors are emerging as critical tools for high-throughput strain improvement in synthetic biology. Many biosensors are developed in model organisms where sophisticated synthetic biology tools are also well established. H
Autor:
Kevin J. Hodgetts, Kevin M. Quist, Hongxia Li, Hrvoje Lusic, Melanie Fritsche, Elliot J. Androphy, Sungwoon Choi, Marcie A. Glicksman, Anne Rietz, Nicholas L. Kern, Xuechao Xing, Jonathan J. Cherry, Christian L. Lorson, Barrington G. Burnett, Alyssa N. Calder, Patrick J. Boaler, Gregory D. Cuny
Publikováno v:
Journal of Medicinal Chemistry. 60:4594-4610
Spinal muscular atrophy (SMA) is the leading genetic cause of infant death. We previously developed a high-throughput assay that employs an SMN2-luciferase reporter allowing identification of compounds that act transcriptionally, enhance exon recogni
Publikováno v:
Fluid Phase Equilibria. 429:275-280
Gas-expanded liquids have received significant interest as catalytic reaction media. While most GXL studies involve CO2 as the expansion gas, there is growing interest in non-CO2 based GXLs, especially when the expansion gas is also a reactant. In th
Autor:
Emily N. Schmidt, David T. Fox, Andrew T. Koppisch, Kellan B. Finney, Charlie E. M. Strauss, Gustavo M. Canales, Ramesh K. Jha, Theresa L. Kern, Lucas B. Harrington
Publikováno v:
ACS Synthetic Biology. 6:120-129
Thermostabilization of an enzyme with complete retention of catalytic efficiency was demonstrated on recombinant 3-dehydroshikimate dehydratase (DHSase or wtAsbF) from Bacillus thuringiensis serovar konkukian 97–27 (hereafter, B. thuringiensis 97
Autor:
Robert Jedrzejczak, Charlie E. M. Strauss, Andrzej Joachimiak, Youngchang Kim, Theresa L. Kern, Christine Tesar, Ramesh K. Jha
Publikováno v:
Nucleic Acids Research
A whole-cell biosensor utilizing a transcription factor (TF) is an effective tool for sensitive and selective detection of specialty chemicals or anthropogenic molecules, but requires access to an expanded repertoire of TFs. Using homology modeling a
Publikováno v:
Fluid Phase Equilibria. 411:81-87
Ethylene is an important industrial feedstock for the generation of commodity chemicals and is increasingly abundant as a by-product of natural gas production. In some cases, the reaction of ethylene can be enhanced by using it to create a gas-expand
Autor:
Devan J. Wilkins, Graham B. Jones, Nicholas L. Kern, David E. Bell, Sara Sadler, Nicholas G. Gedeon, Meaghan M. Sebeika
Publikováno v:
Journal of Flow Chemistry. 5:151-154
Interest in the field of antibody—drug conjugates (ADCs) has grown exponentially over the past decade. As the product pipeline grows, there is increasing need for robust chemistries which allow selective and efficient functionalization of the antib